Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cortex zanthoxyli total alkaloid extract and preparations as well as application thereof

A technology of Mokoupizi and total alkaloids, which is applied in the field of medicine, can solve problems such as adverse reactions, achieve the effects of reducing toxic and side effects, inhibiting the proliferation of joint synoviocytes, and reducing the dosage

Inactive Publication Date: 2015-05-06
HUNAN UNIV OF CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no specific drug for the treatment of rheumatoid arthritis in clinical practice. Usually, it is used to control the inflammation caused by autoimmune diseases and to use drugs that suppress the body's immune response, such as prednisone, methotrexate, cyclophosphamide, thiazole Purine, cyclosporin A, etc., however, these drugs inhibit the inflammatory response and tissue damage caused by the immune response of the body, and also inhibit the anti-infection ability of the immune system, which will produce a series of adverse reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cortex zanthoxyli total alkaloid extract and preparations as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 prepares the total alkaloid extract of Mokoupizi medicine

[0029] Using method I, including the following steps:

[0030] (1) Preparation of crude extract: take 100 kg of the medicinal material of Mossia officinalis, grind it into coarse particles, add 10 times the amount of 0.5% hydrochloric acid aqueous solution to soak for 12 hours, and then carry out percolation extraction, collect percolation liquid, filter, add Adjust the pH value to neutral with sodium hydroxide solution, concentrate under reduced pressure, and concentrate the filtrate to a thick paste to obtain a crude extract;

[0031] (2) Refined extract: Add appropriate amount of distilled water to the crude extract obtained in step (1) to make a suspension, add sodium hydroxide solution to adjust the pH value to 8, and add 4 times the amount of the suspension each time The dichloromethane was extracted three times, the dichloromethane was recovered under reduced pressure, and spray-dried to ob...

Embodiment 2

[0033] Identical to the technical solution of embodiment 1, the only difference is:

[0034] In step (1), add 1.0% aqueous hydrochloric acid solution of 11 times the amount to the coarse granules of the molasses to extract by percolation;

[0035] In step (2), add dichloromethane of 5 times the amount relative to the suspension to the suspension for extraction 4 times each time, add sodium hydroxide solution to adjust the pH value to 9, and finally obtain a total alkaloid content of 60% The total alkaloid extract of Mokopizi medicine.

Embodiment 3

[0037] Identical to the technical solution of embodiment 1, the only difference is:

[0038] In step (1), 12 times the amount of 2.0% hydrochloric acid aqueous solution is added to the coarse granules of Makoupizi to carry out percolation extraction;

[0039] In step (2), add dichloromethane in an amount 6 times that of the suspension to the suspension for 4 extractions each time, and finally obtain a total alkaloid extract with a total alkaloid content of 70%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a cortex zanthoxyli total alkaloid extract and preparations as well as application thereof. The cortex zanthoxyli total alkaloid extract is obtained by extraction from the traditional Chinese medicine cortex zanthoxyli, and refining, wherein the total alkaloid content is basically more than 50%, and is up to 100% in maximum. The invention further provides preparations and medical application of the cortex zanthoxyli total alkaloid extract, wherein the preparations include powder injection, dropping pills, tablets, capsules, granules, and so on. Pharmacodynamic and toxicology tests prove that the cortex zanthoxyli total alkaloid extrac can remarkably restrain proliferation of CIA (Collagen Induced Arthritis) rat joint synovial cells, and has low toxic and side effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an extract of total alkaloids of the herbal medicine Makoupi and its preparation and application. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint synovitis, with a global incidence of 0.5% to 1%. The pathological changes are mainly synoviocyte hyperplasia and lining layer thickening. The fibroblast-like synovial cells in the joint are an important component of the synovial tissue, and play an important role in the process of joint destruction by secreting various cytokines, proteases, arachidonic acid metabolites, etc. At the same time, autoimmune diseases are disease states caused by the body's immune system's immune response to its own components, and have the characteristics of recurrent attacks and chronic migration. Therefore, long-term treatment and monitoring are required. [0003] At present, there is no specific drug for t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/758A61P19/02A61P29/00
Inventor 周小江
Owner HUNAN UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com