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Novel effects of veratrol estrogen receptor antagonist

A technology of estrogen receptors and antagonists, applied in the field of Chinese herbal veratrum extracts

Inactive Publication Date: 2018-11-30
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported that it has anti-estrogen-like effects

Method used

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  • Novel effects of veratrol estrogen receptor antagonist
  • Novel effects of veratrol estrogen receptor antagonist
  • Novel effects of veratrol estrogen receptor antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0177] Crush the veratrum medicinal material into a coarse powder, add 6 times the amount of distilled water, and reflux extraction for 2-3 times, each time for 1 hour. According to the actual administration concentration, concentrate under reduced pressure or dilute to the corresponding concentration for in vivo and in vitro experimental research.

Embodiment 2

[0179] Crush the Veratrum medicinal material into coarse powder, add 6 times the amount of 60-80% ethanol, and reflux extraction for 2-3 times, each time for 1 hour. According to the actual administration concentration, concentrate under reduced pressure or dilute to the corresponding concentration for in vivo and in vitro experimental research.

Embodiment 3

[0181] Crush the veratrum medicinal material into coarse powder, add 2 times the amount of ammonia solution with a volume fraction of 28%, soak for 1 hour; then add 20 times the volume of chloroform-methanol (volume ratio: 4:1), and place in a 70°C water bath Add and reflux for 2 hours, filter, add a mixed solvent to wash the filter residue, collect the filtrate, concentrate under reduced pressure or dilute to the corresponding concentration, and use it for in vitro experimental research.

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PUM

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Abstract

The invention relates to a new application of a traditional Chinese medicine hellebore extract, and particularly relates to a new application of an estrogen receptor antagonist of a hellebore extract.

Description

Technical field: [0001] The invention relates to a new application of a traditional Chinese medicine veratrum extract, in particular to the estrogen receptor antagonist-like effect of the veratrum extract. Background technique: [0002] Estrogen replacement therapy (ERT) is the first choice for the treatment of postmenopausal syndrome, but long-term use can lead to endometrial hyperplasia and breast cancer. Selective estrogen receptor modulators (Selective estrogen receptor modulators, SERM) can relieve perimenopausal symptoms, prevent osteoporosis and urinary incontinence, stabilize the vaginal environment, but do not increase the incidence of malignant tumors. SERM mainly realizes its tissue selectivity through estrogen receptor (estrogen receptor, ER) subtypes, co-regulators, target promoters and other mechanisms. side effect. Among them, ICI 182,780 is a new type of competitive, "pure" ER antagonist, which does not have partial ER agonism, and can block ER signaling pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K31/58A61P5/32A61P15/00A61P15/14A61P35/00A61P15/08
Inventor 林娜徐颖丁婕安金娜马晓萍
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI