Composition of bamboo leaf flavonoid and chitosan oligosaccharide, as well as preparation method and application thereof

A technology of bamboo leaf flavonoids and chitosan oligosaccharides, which is applied in application, food preparation, drug combination, etc., can solve the problems of unfavorable and hidden dangers in the use of preparations, aggravated degradation of bamboo leaf flavonoids, poor stability of bamboo leaf flavonoids, etc.

Active Publication Date: 2015-05-06
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The unfavorable effect is that, on the one hand, the stability of bamboo leaf flavonoids is not good, especially in the water environment, during the processing of preparations, it is often carried out in an aqueous environment and under heating conditions, which intensifies the degradation of bamboo leaf flavonoids , which brings disadvantages and hidden dangers to the safety of the preparation; on the other hand, the curative effect of bamboo leaf flavonoids is relatively weak, and it is usually necessary to use a compound form to improve its curative effect

Method used

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  • Composition of bamboo leaf flavonoid and chitosan oligosaccharide, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1, bamboo leaf flavone chitosan oligosaccharide oral solution and its preparation

[0064] The prescription quantity is calculated by weight percentage and contains:

[0065] Bamboo leaf flavonoids 0.5% to 2.5%, preferably 0.8%,

[0066] Chitooligosaccharide 0.5%~5%, preferably 2%,

[0067] Sucralose 0~0.05%, preferably 0.015%,

[0068] Appropriate amount of arginine, adjust the pH to 4.5-7.5,

[0069] Add purified water to 100%;

[0070] Preparation: (1) Ingredients: Weigh bamboo leaf flavonoids and chitosan oligosaccharides according to the formula, add them into purified water, stir, mix and disperse evenly, and set the volume to the required production volume;

[0071] (2) Dissolving: add arginine to the liquid prepared in (1), make the pH of the liquid 4.5-7.5, preferably pH 6.5, add sucralose, dissolve completely, stir evenly, and obtain a clear solution;

[0072] (3) Filling and sterilization: filter the solution through 500-1000 mesh, vacuum dega...

Embodiment 2

[0074] Embodiment 2, bamboo leaf flavone chitosan oligosaccharide oral solution and its preparation

[0075] The prescription quantity is calculated by weight percentage and contains:

[0076] Bamboo leaf flavonoids 0.5% to 2%, preferably 1%,

[0077] Chitooligosaccharide 0.5%~2.5%, preferably 1%,

[0078] Fructose 0-10%, preferably 7%,

[0079] Glucose 0-10%, preferably 7%,

[0080] An appropriate amount of lysine, adjust the pH to 4.5-7.5,

[0081] Add purified water to 100%;

[0082] Preparation: (1) Ingredients: Weigh bamboo leaf flavonoids and chitosan oligosaccharides according to the formula, add them into purified water, stir, mix and disperse evenly, and set the volume to the required production volume;

[0083] (2) Dissolution: Add lysine to the liquid prepared in (1), dissolve completely, stir to obtain a clear solution, then add fructose and glucose, stir evenly after completely dissolving, so that the pH of the liquid is 4.5-7.5 , preferably pH6.5;

[0084]...

Embodiment 3

[0086] Embodiment 3, bamboo leaf flavonoid chitosan oligosaccharide tablet and its preparation

[0087] The prescription quantity is calculated by weight percentage and contains:

[0088] Bamboo leaf flavonoids 50~100g,

[0089] Chitooligosaccharide 50~80g,

[0090] Mannitol 100~160g,

[0091] Calcium hydrogen phosphate 50~85g,

[0092] Sodium carboxymethyl starch 10~18g,

[0093] 2.5% aqueous solution of hydroxypropyl cellulose appropriate amount,

[0094] Magnesium stearate 5-8g,

[0095] Preparation: Pass bamboo leaf flavonoids, chitosan oligosaccharides, mannitol, calcium hydrogen phosphate, and sodium starch glycolate through 100 mesh sieves, weigh according to the prescription amount, and mix bamboo leaf flavonoids and chitosan oligosaccharides evenly to obtain A Mix the powder and wait for use. In addition, mix the sodium carboxymethyl starch and calcium hydrogen phosphate uniformly according to the method of equal addition, and then mix with mannitol evenly to ob...

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Abstract

The invention provides a health product composition of bamboo leaf flavonoid and chitosan oligosaccharide. The preparation of the composition is an arbitrary pharmaceutically acceptable medicinal preparation, wherein the bamboo leaf flavonoid comprises pharmaceutically acceptable salt or solvate. According to the combination mode of the composition, bamboo leaf flavonoid and chitosan oligosaccharide are respectively prepared into independent preparations, and the two independent preparations are packaged in the same medicine box. The invention further provides a method for preparing the composition, application of the composition in preparation of medicines for resisting atherosclerosis, and application of the composition in preparation of medicines for improving myocardial ischemia and cerebral ischemia, protecting cardio and cerebral cells, reducing blood fat, preventing and treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a health food composition, its preparation method and application, in particular to the composition of bamboo leaf flavone and chitosan oligosaccharide, its preparation method and application. The health product composition of the present invention includes but not limited to medicine, medical food, health food or functional food, common food and so on. Background technique [0002] Bamboo leaf flavonoids are biologically active bioflavonoids extracted from the bamboo leaves of the genus Phyllostachys chinensis in the Gramineae family. It is a highly efficient biological antioxidant and an essential nutrient for the human body. It has the ability to protect the cardiovascular and cerebrovascular, Improve myocardial ischemia, improve cerebral ischemia, regulate blood lipids, and reduce blood viscosity. It has the functions of preventing and treating cardiovascular and cerebrovascular diseases, anti-oxidation, anti-inflammation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/08A61K9/20A61K47/26A61K47/36A61P9/10A61P9/00A23L1/09A61K31/702A61K31/715A23L29/30A23L33/105
Inventor 张耿元王保红白东跃唐湘成
Owner FUZHOU QIANZHENG PHARMA
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