Fire-clearing jasmine and radix ophiopogonis film-coated tablets and preparation method thereof

Abstract

The invention discloses fire-clearing jasmine and radix ophiopogonis film-coated tablets which comprise main ingredients and auxiliary materials, wherein the main ingredients comprise the following components in parts by weight: 700-900 parts of common andrographis Herb, 80-120 parts of jasmine and 80-120 parts of radix ophiopogonis; and the auxiliary materials comprise the following components in parts by weight: 20-30 parts of starch and 0.1-2 parts of magnesium stearate. The invention also discloses a method for preparing the fire-clearing jasmine and radix ophiopogonis film-coated tablets. The fire-clearing jasmine and radix ophiopogonis tablets are changed from the traditional sugar-coated tablets into the film-coated tablets, the coating time is short, the operation is simple and convenient, the drying speed is high, the medicine is slightly affected by damp-heat, and the service life of the product can be prolonged. Moreover, the process stability is high, the drug quality is high, and the market prospects are wide.

Description

technical field [0001] The invention relates to Qinghuo Zhimai film-coated tablets and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Qinghuozhimai is a commonly used variety of Qinghuo traditional Chinese medicine, which was recorded in the 2010 edition of "Chinese Pharmacopoeia", and its prescriptions are Andrographis paniculata, Gardenia and Ophiopogon japonicus. At present, most manufacturers mainly produce sugar-coated tablets, and in recent years, a small number of manufacturers produce film-coated tablets. The advantages of sugar-coated tablets are: the surface of the tablet core is wrapped with a suitable sugar-coated material to isolate the drug from the outside world, so as to achieve the functions of moisture-proof, light-proof, and air oxidation, so as to enhance the stability of the drug during the shelf life, and at the same time cover up the unpleasant smell of the prescription drug....

AI Technical Summary

Problems solved by technology

[0003] (1) The sugar-coated layer of Qinghuozhimai sugar-coated tablets adds a variety of excipients based on talcum powder, sucrose, and gelatin that have nothing to do with drug treatment on the surface of the drug core, so that the sugar-coated tablet is effective. The weight gain reaches 50-100%. Therefore, long-term use will cause great harm to the human body, especially for diabetic patients

[0004] (2) During the production operation of sugar-coated tablets, large dust is generated, which pollutes the environment, and sugar, glue, adding pigments, drying tablets, and material storage all need to occupy a large space in the workshop

[0005] (3) The production process is complicated, and most of the operations rely on the operator's experience and hand feeling to control the coating quality, so it is difficult to control the uniformity of product quality

[0006] (4) During the coating process, there are many problems such as splits, flowers, mildew, overtime disintegration, content drop, strong hygroscopicity, difficult storage, long production time and drying time, etc.