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New pharmaceutical composition for the treatment of fungal infections

A composition and drug technology, applied in the direction of drug combination, antifungal agent, drug delivery, etc., can solve the problems of undisclosed use of trihydric alcohols, etc., and achieve the effect of easy storage

Active Publication Date: 2015-05-27
阿德凡蒂斯健康公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] To the applicant's knowledge, there is no disclosure in the prior art of the use of trihydric alcohols such as glycerol to chemically stabilize urea when it is dissolved or present in a liquid or solution based pharmaceutical composition

Method used

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  • New pharmaceutical composition for the treatment of fungal infections
  • New pharmaceutical composition for the treatment of fungal infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0076] Composition I comprising glycerol

[0077] Compositions with the following proportioned ingredients were prepared in 0.5 kg batches by dissolving urea in propylene glycol and glycerin before adding lactic acid and then 10M aqueous NaOH.

[0078] components

Embodiment 3

[0080] Composition II comprising glycerol

[0081] Compositions having the following proportioned ingredients were prepared in 50 g batches by dissolving urea hydrogen peroxide in lactic acid and glycerin prior to adding propylene glycol and urea. 10M NaOH was added at the end of the sample preparation when the urea was completely dissolved.

[0082] components

Embodiment 4

[0084] Composition III comprising glycerol

[0085] Compositions with the following proportioned ingredients were prepared in 3 kg batches by dissolving urea in propylene glycol and glycerin before adding lactic acid and then 10M aqueous NaOH.

[0086] components

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PUM

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Abstract

There is provided pharmaceutical compositions suitable for topical application to the nail for the treatment of nail diseases such as onychomycosis, comprising a urea-based component, a diol component, such as propylene glycol, an organic acid component, such as lactic acid, and a triol component, such a glycerol. There is further provided methods of improving the storage stability of a pharmaceutical composition suitable for topical application to the skin and / or nails comprising such urea-based components, diol components, organic acid components, and, optionally, an aqueous base, which method comprises adding a triol component, such a glycerol, to that composition prior to said storage.

Description

technical field [0001] The present invention relates to new pharmaceutical compositions useful for topical application in the treatment of fungal nail infections, especially onychomycosis. Background technique [0002] Fungal infections of the nails are more common than commonly believed. It is often considered a minor problem that affects only a few people. In fact, it is the most common nail disorder, affecting about 100 million patients in Europe and North America. The prevalence is about 10% in the general population and more than 25% in people over 50 years old. [0003] Onychomycosis is the most common fungal nail disease and affects approximately 6% to 8% of the adult population. Onychomycosis can affect toenails and fingernails and is characterized by thickening and discoloration of the nails. As a result, opaque, thick and / or brittle nail lesions form due to fungal attack. The nails become dry and crack or flake off, often showing a yellowish tint. [0004] Na...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/34A61K8/42A61Q19/00A61P17/06A61K47/10A61K47/12A61K47/18A61K9/00
CPCA61K9/0014A61K47/10A61K9/08A61K31/19A61K31/047A61K31/17A61K31/197A61P17/00A61P17/06A61P31/10
Inventor E·卡尔松S·F·阿什卡尔P·考夫曼
Owner 阿德凡蒂斯健康公司
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