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Metronidazole effervescent tablet for vagina and preparation technology of metronidazole effervescent tablet

A technology for effervescent tablets and metronidazole tablets, which are applied to vaginal effervescent tablets, vaginal effervescent tablets containing metronidazole and the field of preparation technology thereof, can solve the problem of vaginal discomfort of patients, lyophilized tablets are easy to absorb moisture, Complex process and other problems, to achieve the effect of easy industrialized large-scale production, reducing the amount of auxiliary materials, and simple preparation process

Inactive Publication Date: 2015-06-03
尹克春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, a large amount of water-insoluble excipients can easily cause vaginal discomfort in patients, and adding sodium bicarbonate at the same time can easily cause drug degradation
[0005] CN102784120B discloses a vaginal freeze-dried disintegrating tablet of metronidazole composition, which is prepared by cyclodextrin inclusion technology. The process is relatively complicated, and the freeze-dried tablet is easier to absorb moisture and requires more stringent packaging

Method used

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  • Metronidazole effervescent tablet for vagina and preparation technology of metronidazole effervescent tablet
  • Metronidazole effervescent tablet for vagina and preparation technology of metronidazole effervescent tablet
  • Metronidazole effervescent tablet for vagina and preparation technology of metronidazole effervescent tablet

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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 metronidazole vaginal effervescent tablet

[0022]

[0023] Preparation Process:

[0024] (1) Pass metronidazole and maleic acid through a 100-mesh sieve, weigh the prescription amount, mix evenly, add an appropriate amount of pure water as a binder, wet granulate, dry at 60°C, granulate with a 16-mesh sieve, and dry particles;

[0025] (2) add the glyceryl behenate of recipe quantity in the dry granule that step (1) obtains, mix homogeneously, tabletting, obtain metronidazole tablet core;

[0026] (3) Sodium carbonate and polyvinyl alcohol of prescription quantity are dissolved in 40 ℃ of water, use this solution as coating solution, the metronidazole tablet core surface coating that obtains in step (2), obtain metronidazole vaginal effervescence piece.

Embodiment 2

[0027] The preparation of embodiment 2 metronidazole vaginal effervescent tablets

[0028]

[0029] Preparation Process:

[0030] (1) Pass metronidazole and maleic acid through a 100-mesh sieve, weigh the prescription amount, mix evenly, add an appropriate amount of pure water as a binder, wet granulate, dry at 60°C, granulate with a 16-mesh sieve, and dry particles;

[0031] (2) add the glyceryl behenate of recipe quantity in the dry granule that step (1) obtains, mix homogeneously, tabletting, obtain metronidazole tablet core;

[0032] (3) Sodium carbonate and polyvinyl alcohol of prescription quantity are dissolved in 40 ℃ of water, use this solution as coating solution, the metronidazole tablet core surface coating that obtains in step (2), obtain metronidazole vaginal effervescence piece.

Embodiment 3

[0033] The preparation of embodiment 3 metronidazole vaginal effervescent tablets

[0034]

[0035] Preparation Process:

[0036] (1) Pass metronidazole and maleic acid through a 100-mesh sieve, weigh the prescription amount, mix evenly, add an appropriate amount of pure water as a binder, wet granulate, dry at 60°C, granulate with a 16-mesh sieve, and dry particles;

[0037] (2) add the glyceryl behenate of recipe quantity in the dry granule that step (1) obtains, mix homogeneously, tabletting, obtain metronidazole tablet core;

[0038] (3) Sodium carbonate and polyvinyl alcohol of prescription quantity are dissolved in 40 ℃ of water, use this solution as coating solution, the metronidazole tablet core surface coating that obtains in step (2), obtain metronidazole vaginal effervescence piece.

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Abstract

The invention discloses a metronidazole effervescent tablet for vagina and a preparation technology of the metronidazole effervescent tablet. The tablet is prepared from a metronidazole tablet core and an alkaline coating layer, wherein the metronidazole tablet core contains an acid component; and the metronidazole tablet core is wrapped with the alkaline coating layer. Compared with the prior art, an acid effervescing agent and an alkaline effervescing agent are effectively separated; the problem of the stability of the metronidazole effervescent tablet in preparation and storage processes is successfully solved; meanwhile, the amount of auxiliary materials is greatly reduced; the tablet weight is reduced; and medication of patients is facilitated.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a vaginal effervescent tablet, in particular to a vaginal effervescent tablet containing metronidazole and a preparation process thereof. Background technique [0002] There are many types of female reproductive organ diseases. Since a part of the female reproductive organs is exposed, the skin in these parts is also prone to some symptoms such as itching and pain, which makes it difficult for patients to speak and brings great inconvenience. Such as genital pruritus, genital eczema, genital leukoplakia, acute vulvar ulcer, pelvic infection, etc. Metronidazole preparations currently used for the treatment of female genital diseases are suppositories and effervescent tablets. However, suppositories are based on polyoxyethylene monoester acid and glycerin, which is inconvenient for transportation and storage. They are required to be stored below 30°...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/4164A61K47/02A61K47/12A61K47/14A61K47/32A61P15/00
Inventor 王菊明
Owner 尹克春
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