A kind of clopyrrole hydrogen sulfate tablet and preparation technology thereof
A technology of clopyrrole bisulfate tablets and clopyrrole bisulfate, which is applied in pill delivery, medical preparations of non-active ingredients, blood diseases, etc., and can solve problems such as poor patient compliance, easy sticking and punching of tablets, and heavy tablets, etc. problem, to achieve the effect of facilitating drug use, avoiding the problem of sticking and punching, and reducing tablet weight
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Embodiment 1
[0028]
[0029] Preparation Process:
[0030] (1) The recipe quantity takes by weighing clopyrrole hydrogen sulfate, joins in the prescription quantity dehydrated alcohol, stirs to dissolve, then adds the crospovidone crossing 100 mesh sieves of the prescription quantity, stirs and mixes evenly, and puts on the spray drier , the drying temperature is set at 55°C, the spray speed is 45ml / min, the suspension is spray-dried, and the dry matter in the receiving room is collected to prepare the clopyrrole hydrogen sulfate cross-linked povidone complex;
[0031] (2) Mix the compound obtained in step (1) with the prescribed amount of zinc stearate in a multi-sport mixer, and compress it into tablets using a rotary tablet press.
Embodiment 2
[0033]
[0034] Preparation Process:
[0035] (1) The recipe quantity takes by weighing clopyrrole hydrogen sulfate, joins in the prescription quantity dehydrated alcohol, stirs to dissolve, then adds the crospovidone crossing 100 mesh sieves of the prescription quantity, stirs and mixes evenly, and puts on the spray drier , the drying temperature is set at 50°C, the spray speed is 40ml / min, the suspension is spray-dried, and the dry matter in the receiving room is collected to prepare the clopyrrole hydrogen sulfate cross-linked povidone compound;
[0036] (2) Mix the compound obtained in step (1) with the prescribed amount of sodium stearyl fumarate in a multi-motion mixer, and press into tablets with a rotary tablet press.
Embodiment 3
[0038]
[0039] Preparation Process:
[0040] (1) The recipe quantity takes by weighing clopyrrole hydrogen sulfate, joins in the prescription quantity dehydrated alcohol, stirs to dissolve, then adds the crospovidone crossing 80 mesh sieves of the recipe quantity, stirs and mixes evenly, on the spray drier , the drying temperature is set at 50°C, the spray speed is 40ml / min, the suspension is spray-dried, and the dry matter in the receiving room is collected to prepare the clopyrrole hydrogen sulfate cross-linked povidone compound;
[0041] (2) Mix the compound obtained in step (1) with the prescribed amount of zinc stearate in a multi-sport mixer, and compress it into tablets using a rotary tablet press.
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