Bendroflumethiazide tablet and preparation method thereof

Benfluflumethiazide tablets and Benfluflumethiazide technology, which are applied in the field of Benfluflumethiazide tablets and their preparation, can solve problems such as content differences among bendrofluthiazide tablets, and achieve easy industrialized large-scale production and preparation processes Simple, fast-dissolving results

Inactive Publication Date: 2017-07-14
HUAYI PHARMA ANHUI CO LTD
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a bendrofluthiazide tablet and a preparation method thereof, which solves

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bendroflumethiazide tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1

[0026] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 4Kg, lactose 6Kg, sodium starch glycolate 0.4Kg, hard Magnesium fatty acid 0.03Kg.

[0027] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0028] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0029] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0030] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0031] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg / tablet.

Example Embodiment

[0032] Example 2

[0033] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 6Kg, lactose 4Kg, sodium starch glycolate 0.6Kg, hard Magnesium fatty acid 0.02Kg.

[0034] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0035] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0036] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0037] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0038] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg / tablet.

Example Embodiment

[0039] Example 3

[0040] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 2Kg, lactose 8Kg, sodium starch glycolate 0.2Kg, hard Magnesium fatty acid 0.04Kg.

[0041] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0042] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0043] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0044] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0045] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg / tablet.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a bendroflumethiazide tablet and a preparation method thereof and belongs to the technical field of medicine preparations. The bendroflumethiazide tablet is composed of, by weight, 0.25-0.5 parts of bendroflumethiazide, 2-6 parts of microcrystalline cellulose PH-102, 4-8 parts of lactose, 0.2-0.6 parts of carboxymethyl starch sodium, and 0.02-0.04 parts of magnesium stearate. The preparation method of the bendroflumethiazide tablet includes the steps of: performing air jet pulverization to the bendroflumethiazide; uniformly mixing the bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate to obtain a mixture material; adding the lactose and carboxymethyl starch sodium to the mixture material, and uniformly mixing the materials; and performing dry-method direct tabletting to obtain the bendroflumethiazide tablet. The bendroflumethiazide tablet is more homogenous in content of bendroflumethiazide and is more rapidly to dissolve out in 5 min. The preparation method is simple, wherein the auxiliary materials, except the microcrystalline cellulose PH-102, are free of special pulverization treatment. The preparation method is free of complex preparation devices and is easy to achieve in industrial production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a bendrofluthiazide tablet and a preparation method thereof. Background technique [0002] Benzoflumethiazide is 3-benzyl-6-trifluoromethyl-7-sulfonylamino-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide thing. [0003] Efficacy and indications: 1. Edema diseases, excrete excess sodium and water in the body, reduce extracellular fluid volume, and eliminate edema. Common ones include congestive heart failure, cirrhotic ascites, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention caused by adrenal corticosteroid and estrogen therapy. 2. High blood pressure. It can be used alone or in combination with other antihypertensive drugs. Mainly used for the treatment of essential hypertension. 3. Central or nephrogenic diabetes insipidus. 4. Nephrolithiasis. It is mainly used to prevent stones formed by...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K47/38A61K31/549A61P7/10A61P9/12A61P7/12A61P13/12A61P13/04
CPCA61K9/2054A61K9/2095A61K31/549
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap