Bendroflumethiazide tablet and preparation method thereof

Benfluflumethiazide tablets and Benfluflumethiazide technology, which are applied in the field of Benfluflumethiazide tablets and their preparation, can solve problems such as content differences among bendrofluthiazide tablets, and achieve easy industrialized large-scale production and preparation processes Simple, fast-dissolving results

Inactive Publication Date: 2017-07-14

HUAYI PHARMA ANHUI CO LTD

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AI-Extracted Technical Summary

Problems solved by technology

[0009] The invention provides a bendrofluthiazide tablet and a preparation method thereof, which solves...

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Abstract

The invention discloses a bendroflumethiazide tablet and a preparation method thereof and belongs to the technical field of medicine preparations. The bendroflumethiazide tablet is composed of, by weight, 0.25-0.5 parts of bendroflumethiazide, 2-6 parts of microcrystalline cellulose PH-102, 4-8 parts of lactose, 0.2-0.6 parts of carboxymethyl starch sodium, and 0.02-0.04 parts of magnesium stearate. The preparation method of the bendroflumethiazide tablet includes the steps of: performing air jet pulverization to the bendroflumethiazide; uniformly mixing the bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate to obtain a mixture material; adding the lactose and carboxymethyl starch sodium to the mixture material, and uniformly mixing the materials; and performing dry-method direct tabletting to obtain the bendroflumethiazide tablet. The bendroflumethiazide tablet is more homogenous in content of bendroflumethiazide and is more rapidly to dissolve out in 5 min. The preparation method is simple, wherein the auxiliary materials, except the microcrystalline cellulose PH-102, are free of special pulverization treatment. The preparation method is free of complex preparation devices and is easy to achieve in industrial production.

Application Domain

Organic active ingredientsUrinary disorder +5

Technology Topic

Magnesium stearatePharmaceutical formulation +5

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Examples

Experimental program(5)
Effect test(1)

Example Embodiment

[0025] Example 1

[0026] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 4Kg, lactose 6Kg, sodium starch glycolate 0.4Kg, hard Magnesium fatty acid 0.03Kg.

[0027] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0028] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0029] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0030] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0031] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg/tablet.

Example Embodiment

[0032] Example 2

[0033] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 6Kg, lactose 4Kg, sodium starch glycolate 0.6Kg, hard Magnesium fatty acid 0.02Kg.

[0034] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0035] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0036] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0037] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0038] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg/tablet.

Example Embodiment

[0039] Example 3

[0040] This embodiment provides a benzylfluorothiazide tablet, which is composed of the following components in parts by weight: benzylfluorothiazide 0.25Kg, microcrystalline cellulose PH-102 2Kg, lactose 8Kg, sodium starch glycolate 0.2Kg, hard Magnesium fatty acid 0.04Kg.

[0041] The preparation method of the above benzylfluorothiazide tablets includes the following steps:

[0042] (1) Air jet pulverization of benzylfluorothiazide, air jet pulverization control D90 = 30-60 microns;

[0043] (2) Take benzylfluorothiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixture;

[0044] (3) Add lactose and sodium starch glycolate to the mixture and mix well;

[0045] (4) Adopting dry method to directly compress tablets, the batch size is 100,000 tablets, and the tablet specification is 2.5mg/tablet.

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Uniform content
Promote dissolution

Bendroflumethiazide tablet and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

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Examples

Example Embodiment

Example Embodiment

Example Embodiment

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Description & Claims & Application Information

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