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Bendroflumethiazide tablet and preparation method thereof

Benfluflumethiazide tablets and Benfluflumethiazide technology, which are applied in the field of Benfluflumethiazide tablets and their preparation, can solve problems such as content differences among bendrofluthiazide tablets, and achieve easy industrialized large-scale production and preparation processes Simple, fast-dissolving results

Inactive Publication Date: 2017-07-14
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a bendrofluthiazide tablet and a preparation method thereof, which solves the problem that there is a large difference in content between the existing bendrofluthiazide tablets

Method used

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  • Bendroflumethiazide tablet and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides a bendroflumethiazide tablet, which is made up of the following components in parts by weight: bendroflumethiazide 0.25Kg, microcrystalline cellulose PH-102 4Kg, lactose 6Kg, carboxymethyl starch sodium 0.4Kg, hard Magnesium fatty acid 0.03Kg.

[0027] The preparation method of above-mentioned bendroflumethiazide tablet, comprises the following steps:

[0028] (1) Perform jet milling of bendroflumethiazide, and the jet milling control D90=30-60 microns;

[0029] (2) get bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixed material;

[0030] (3) Add lactose and carboxymethyl starch sodium into the mixture, and mix well;

[0031] (4) Direct tablet compression by dry method, with a batch size of 100,000 tablets and a tablet specification of 2.5 mg / tablet.

Embodiment 2

[0033] This embodiment provides a bendroflumethiazide tablet, which is composed of the following components in parts by weight: bendroflumethiazide 0.25Kg, microcrystalline cellulose PH-102 6Kg, lactose 4Kg, carboxymethyl starch sodium 0.6Kg, hard Magnesium fatty acid 0.02Kg.

[0034] The preparation method of above-mentioned bendroflumethiazide tablet, comprises the following steps:

[0035] (1) Perform jet milling of bendroflumethiazide, and the jet milling control D90=30-60 microns;

[0036] (2) get bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixed material;

[0037] (3) Add lactose and carboxymethyl starch sodium into the mixture, and mix well;

[0038] (4) Direct tablet compression by dry method, with a batch size of 100,000 tablets and a tablet specification of 2.5 mg / tablet.

Embodiment 3

[0040] This embodiment provides a bendroflumethiazide tablet, which is composed of the following components in parts by weight: bendroflumethiazide 0.25Kg, microcrystalline cellulose PH-102 2Kg, lactose 8Kg, carboxymethyl starch sodium 0.2Kg, hard Magnesium fatty acid 0.04Kg.

[0041] The preparation method of above-mentioned bendroflumethiazide tablet, comprises the following steps:

[0042] (1) Perform jet milling of bendroflumethiazide, and the jet milling control D90=30-60 microns;

[0043] (2) get bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate and mix uniformly to obtain a mixed material;

[0044] (3) Add lactose and carboxymethyl starch sodium into the mixture, and mix well;

[0045] (4) Direct tablet compression by dry method, with a batch size of 100,000 tablets and a tablet specification of 2.5 mg / tablet.

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Abstract

The invention discloses a bendroflumethiazide tablet and a preparation method thereof and belongs to the technical field of medicine preparations. The bendroflumethiazide tablet is composed of, by weight, 0.25-0.5 parts of bendroflumethiazide, 2-6 parts of microcrystalline cellulose PH-102, 4-8 parts of lactose, 0.2-0.6 parts of carboxymethyl starch sodium, and 0.02-0.04 parts of magnesium stearate. The preparation method of the bendroflumethiazide tablet includes the steps of: performing air jet pulverization to the bendroflumethiazide; uniformly mixing the bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate to obtain a mixture material; adding the lactose and carboxymethyl starch sodium to the mixture material, and uniformly mixing the materials; and performing dry-method direct tabletting to obtain the bendroflumethiazide tablet. The bendroflumethiazide tablet is more homogenous in content of bendroflumethiazide and is more rapidly to dissolve out in 5 min. The preparation method is simple, wherein the auxiliary materials, except the microcrystalline cellulose PH-102, are free of special pulverization treatment. The preparation method is free of complex preparation devices and is easy to achieve in industrial production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a bendrofluthiazide tablet and a preparation method thereof. Background technique [0002] Benzoflumethiazide is 3-benzyl-6-trifluoromethyl-7-sulfonylamino-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide thing. [0003] Efficacy and indications: 1. Edema diseases, excrete excess sodium and water in the body, reduce extracellular fluid volume, and eliminate edema. Common ones include congestive heart failure, cirrhotic ascites, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention caused by adrenal corticosteroid and estrogen therapy. 2. High blood pressure. It can be used alone or in combination with other antihypertensive drugs. Mainly used for the treatment of essential hypertension. 3. Central or nephrogenic diabetes insipidus. 4. Nephrolithiasis. It is mainly used to prevent stones formed by...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K31/549A61P7/10A61P9/12A61P7/12A61P13/12A61P13/04
CPCA61K9/2054A61K9/2095A61K31/549
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
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