35results about How to "Advantages and Significant Advancements" patented technology

The invention discloses novel graded targeted nanoparticles for mediating phototherapy and a preparation method and application of the novel graded targeted nanoparticles. The targeted nanoparticles are of a core-shell-shell spherical structure, and is prepared by adopting a W/O/W double emulsification method; and 5-ALA and CAT are distributed inside the nanoparticles as a water phase, TPP and PLGA are taken as an oil phase to form the inner shells of the nanoparticles, and the outermost layer is coated with HA to be taken as the outer shells. The nanoparticles can actively target tumor cellsand efficiently deliver a photosensitizer 5-ALA; in addition, the nanoparticles can effectively alleviate the TME hypoxia by further targeting mitochondria in the tumor cells and generating a large amount of oxygen through CAT, and can produce a large amount of ROS and enhance the killing effect of ROS under laser irradiation, so that an enhanced anti-tumor effect is exerted.

The invention discloses a mosapride citrate tablet and a preparation method thereof. The tablet is obtained by virtue of wet granulation and tableting; a binder adopted for wet granulation is the aqueous solution of mosapride citrate and povidone K15. Compared with the prior art, the mosapride citrate tablet is quick in drug dissolution, stable in quality, simple in preparation process without complex preparation equipment, and prone to industrial mass production.

The invention provides a preparation method and applications of a magnetically modified loess adsorbent. According to the preparation method, a soluble ferric salt is mixed with an alkali, and solvothermal method is adopted for synthesis so as to obtain nanometer magnetic Fe3O4; and the obtained nanometer magnetic Fe3O4 and activated loess are mixed and then are reacted at sealed conditions at 150to 200 DEG C so as to obtain the magnetically modified loess adsorbent. The removing rate of the magnetically modified loess adsorbent on methylene blue is 90% or higher; after adsorption, separationfrom water body is convenient to realize because of the magnetic properties. The raw materials are easily available and cheap; the preparation method is simple; cost is low; and the preparation method is beneficial for industrialized production.

The invention discloses a felodipine sustained release tablet and a preparation technology thereof and belongs to the field of chemical drug preparations. The felodipine sustained release tablet comprises a felodipine solid dispersion agent, a filling agent, a disintegrating agent and a lubricating agent. The method comprises the following steps: mixing and suspending felodipine, carbomer resin and sodium alginate in absolute ethyl alcohol, drying and removing ethyl alcohol, thereby acquiring the felodipine solid dispersion agent; uniformly mixing with the filling agent and the disintegratingagent, by taking 60% ethyl alcohol as an adhesive, pelletizing and drying at 45 DEG C, thereby acquiring medicated particles; filtering the medicated particles with a 18-mesh sieve, uniformly mixing with a prescription amount of lubricating agent and preforming. The invention successfully solves the problem of felodipine sustained release; the drugs can be completely released; the effective bloodconcentration can be long-term maintained; the bioavailability is high; the preparation process is simple and is suitable for industrial production.

The invention discloses a metronidazole effervescent tablet for vagina and a preparation technology of the metronidazole effervescent tablet. The tablet is prepared from a metronidazole tablet core and an alkaline coating layer, wherein the metronidazole tablet core contains an acid component; and the metronidazole tablet core is wrapped with the alkaline coating layer. Compared with the prior art, an acid effervescing agent and an alkaline effervescing agent are effectively separated; the problem of the stability of the metronidazole effervescent tablet in preparation and storage processes is successfully solved; meanwhile, the amount of auxiliary materials is greatly reduced; the tablet weight is reduced; and medication of patients is facilitated.

The invention discloses a crotamiton-containing external preparation and a preparation process thereof. The external preparation is prepared from the following components in parts by weight: 100 parts of crotamiton, 200-400 parts of diethylene glycol monoethyl ether, 100-200 parts of decanoyl/octanoyl-glycerides and 400-600 parts of poloxamers. The preparation process particularly comprises the following steps: dissolving the crotamiton into the diethylene glycol monoethyl ether; then adding the decanoyl/octanoyl-glycerides and the poloxamers; and stirring for dissolution. The preparation process disclosed by the invention is simple, fundamentally avoids the problem that a medicament is separated from a matrix and is favorable to long-term storage and transportation.

The invention provides an ionic liquid lubricant for titanium alloy and a preparation method and applications thereof. The ionic liquid has a structure represented by the formula (I), in the formula (I), R1, R2, R3 and R4 individually represent a C2-C8 alkyl group and R5 represents a C1-C16 perfluoro-alkyl group. During the friction process, a firm and sequenced physical adsorption protective filmand a chemical reaction protective film are formed on the surface of a metal friction pair; and thus the lubricant has an excellent friction reducing performance and a wear resistant property.

The invention discloses a clopidogrel sulfate tablet and a preparation process thereof. The tablet contains compound of clopidogrel sulfate and polyvinylpolypyrrolidone, wherein the compound is prepared by the steps of dissolving clopidogrel sulfate in an alcohol solvent, adding polyvinylpolypyrrolidone, uniformly mixing and drying by spray. The clopidogrel sulfate and polyvinylpolypyrrolidone compound prepared by the process is capable of avoiding adhesion in the producing process and successfully solving the stability problem in clopidogrel sulfate preparing and storing processes, is simple in process, and is easy for industrial large-scale production.

The invention discloses a rosuvastatin calcium tablet and a preparation process thereof, and belongs to chemical medicinal preparations. The rosuvastatin calcium tablet is formed by uniformly mixing rosuvastatin calcium solid dispersions with pharmaceutically-acceptable accessories and then carrying out direct compression, the rosuvastatin calcium solid dispersions are obtained by suspending rosuvastatin calcium, a polystyrene maleic anhydride copolymer and poloxamer 407 in absolute ethyl alcohol and drying to remove ethyl alcohol, the rosuvastatin calcium solid dispersions are uniformly mixed with the other pharmaceutically-acceptable accessories, and then the direct compression is carried out. According to the rosuvastatin calcium tablet and the preparation process thereof, the problem of release of the rosuvastatin calcium is successfully solved, and the dissolution stability of the rosuvastatin calcium is remarkably improved.

The invention provides a preparation method of seasoned peony seed leisure food, and belongs to the technical field of deep processing of peony seeds. According to the method, ultrasonic-assisted hot water debitterizing is adopted, a synergistic effect is achieved after an ultrasonic method and a hot water debitterizing method are combined, the debitterizing time is obviously shortened, and industrial rapid production of debitterized peony seeds is facilitated; besides, the debittered peony seeds are deeply processed, so that the peony seed leisure food with three different tastes is provided, and consumers in different regions and at different ages can enjoy the peony seed leisure food.

The invention discloses a telmisartan hydrochlorothiazide tablet and a preparation method thereof. The telmisartan hydrochlorothiazide tablet is prepared by coating a drug-containing element tablet, the drug-containing element tablet is prepared by uniformly mixing the following raw materials and auxiliary materials in percentage by mass: 13%-28% of telmisartan sodium, 2%-5% of hydrochlorothiazide, 2%-10% of a hydrophilic polymer material, 25%-40% silicified microcrystalline cellulose, 25%-40% lactose 316, 4%-6% of a disintegrating agent, 2%-4% of an adhesive and 0.5%-1.5% of a lubricant. According to the invention, by adding the hydrophilic polymer material, when the tablet is in an environment with high humidity, the hydrophilic polymer material absorbs water and plays a good role in protecting the raw materials, and besides, the process is simple and is suitable for industrial production.

The invention discloses a compound alpha-ketonic acid tablet and a preparation method of same. In the invention, five ketonic acids and five amino acids are subjected to wet-process granulation independently, and then the granules are blended and tabletted, finally the tablets are coated. With organic alcohols as a wetting agent, problems of agglomeration and high viscosity during the granulationare solved, so that security of the medicine is guaranteed. Through specific selection on auxiliary materials, the tablet has excellent dispersibility and binding capability and shows outstanding disintegration capability. The tablet has enough smoothness and hardness and has excellent appearance. By matching the auxiliary materials with the main material, excellent dissolution property of the tablet is guaranteed, and excellent stability during subsequent storage process is achieved. The compound alpha-ketonic acid tablet has excellent appearance, is good in compressibility and dissolubility,has simple and stable processes and is suitable for demands of industrial large-scale production.

The invention discloses application of a strain of novel acrocalymma sp. QTY in the field of biological control. The acrocalymma sp. QTY is obtained by separating from Qinling medicinal plant-sinomenium acutum, and then purifying; the isogeny degree between the acrocalymma sp. QTY and acrocalymma cycadis of morosphaeriaceae is the highest and reaches 94%; the strain provided by the invention is anew strain and is name as acrocalymma sp. QTY. The acrocalymma sp. QTY, is preserved in China Center for Type Culture Collection (CCTCC) on January 25, 2018, and has a preservation number of CCTCC M 2018058. The acrocalymma sp. QTY has a very strong inhibitory effect on apple anthracnose pathogen, apple rot pathogen, wheat gibberellic disease pathogen, tomato gray mold pathogen, tomato early blight pathogen, rice blast pathogen and potato dry rot pathogen, and the relative inhibition rates of the plant pathogens are respectively 100%, 96%, 92%, 100%, 96%, 100% and 100%; therefore, the novel acrocalymma sp. QTY can be applied to the field of biological control and is used for preventing and controlling the plant diseases caused by the pathogens.

The invention relates to a trimebutine maleate dispersible tablet and a preparation method thereof, and belongs to the technical field of medical supplies characterized by used non-effective components. The trimebutine maleate dispersible tablet is prepared from trimebutine maleate, auxiliary materials and additives for adjusting the whole uniformity and dispersibility of the tablet, wherein the auxiliary materials and the additives are added by taking trimebutine maleate as a reference, and the auxiliary materials are prepared from lactose, starch and hypromellose E5. The trimebutine maleatedispersible tablet provided by the invention has the advantages of stable release performance, high bioavailability and the like in different in vitro environments when being applied to processing ofpreparations for conditioning functional disturbances of gastrointestinal tracts.

The invention discloses a bendroflumethiazide tablet and a preparation method thereof and belongs to the technical field of medicine preparations. The bendroflumethiazide tablet is composed of, by weight, 0.25-0.5 parts of bendroflumethiazide, 2-6 parts of microcrystalline cellulose PH-102, 4-8 parts of lactose, 0.2-0.6 parts of carboxymethyl starch sodium, and 0.02-0.04 parts of magnesium stearate. The preparation method of the bendroflumethiazide tablet includes the steps of: performing air jet pulverization to the bendroflumethiazide; uniformly mixing the bendroflumethiazide, microcrystalline cellulose PH-102 and magnesium stearate to obtain a mixture material; adding the lactose and carboxymethyl starch sodium to the mixture material, and uniformly mixing the materials; and performing dry-method direct tabletting to obtain the bendroflumethiazide tablet. The bendroflumethiazide tablet is more homogenous in content of bendroflumethiazide and is more rapidly to dissolve out in 5 min. The preparation method is simple, wherein the auxiliary materials, except the microcrystalline cellulose PH-102, are free of special pulverization treatment. The preparation method is free of complex preparation devices and is easy to achieve in industrial production.

The invention discloses a preparation method of polygonatum sibiricum red-sourced resistant starch containing noodles. The preparation method comprises the following steps: preparing polygonatum sibiricum red-sourced resistant starch from polygonatum sibiricum red as a raw material, and jointly processing the polygonatum sibiricum red-sourced resistant starch, a polygonatum sibiricum red starch processing byproduct, namely a polygonatum sibiricum red extract, and wheat flour into high-quality noodles with special active components of the polygonatum sibiricum red. The raw material polygonatumsibiricum red is fully utilized, and the health-care functions of the raw material are embodied; the processed noodles are not only high in quality, low in broken rate, sufficient in elasticity, smallin cooking loss and excellent in palatability; and the problem that the quality of the original wheat-flour noodles is reduced after addition of a large amount of resistant starch is effectively solved.