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Crotamiton-containing external preparation and preparation process thereof

The technology of an external preparation and preparation process is applied in the field of external preparations containing crotamiton and its preparation process, which can solve the problems of complex process, strong greasy feeling, high production cost, etc., and achieve simple preparation process, improved drug effect, and improved The effect of product quality

Inactive Publication Date: 2014-06-04
韩峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, crotamiton cream that has been on the market uses stearic acid, glyceryl monostearate, and glycerin as excipients, and the greasy feeling is too strong when applied externally, and the process is relatively complicated, and emulsification equipment is required, and the production cost is high. high

Method used

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  • Crotamiton-containing external preparation and preparation process thereof
  • Crotamiton-containing external preparation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Crotamiton 100g

[0038] Diethylene glycol monoethyl ether 220g

[0039] Glyceryl Caprylate 130g

[0040] Poloxamer 407 550g

[0041] Preparation Process:

[0042] Dissolve crotamiton in diethylene glycol monoethyl ether, then add caprylic capric acid glyceride and poloxamer 407, heat to 40°C, and stir to dissolve.

Embodiment 2

[0044] Crotamiton 100g

[0045] Diethylene glycol monoethyl ether 285g

[0046] Glyceryl Caprylate 165g

[0047] Poloxamer 407 450g

[0048] Preparation Process:

[0049] Dissolve crotamiton in diethylene glycol monoethyl ether, then add caprylic capric acid glyceride and poloxamer 407, heat to 40°C, and stir to dissolve.

Embodiment 3

[0051] Crotamiton 100g

[0052] Diethylene glycol monoethyl ether 300g

[0053] Glyceryl Caprylate 130g

[0054] Poloxamer 407 520g

[0055] Preparation Process:

[0056] Dissolve crotamiton in diethylene glycol monoethyl ether, then add caprylic capric acid glyceride and poloxamer 407, heat to 40°C, and stir to dissolve.

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Abstract

The invention discloses a crotamiton-containing external preparation and a preparation process thereof. The external preparation is prepared from the following components in parts by weight: 100 parts of crotamiton, 200-400 parts of diethylene glycol monoethyl ether, 100-200 parts of decanoyl / octanoyl-glycerides and 400-600 parts of poloxamers. The preparation process particularly comprises the following steps: dissolving the crotamiton into the diethylene glycol monoethyl ether; then adding the decanoyl / octanoyl-glycerides and the poloxamers; and stirring for dissolution. The preparation process disclosed by the invention is simple, fundamentally avoids the problem that a medicament is separated from a matrix and is favorable to long-term storage and transportation.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for external use, in particular to an external preparation containing crotamiton and a preparation process thereof. Background technique [0002] Scabies is a chronic contagious skin disease caused by scale mites parasitizing on the epidermis of the human body. It has a local epidemic trend. Key role. Scabies tends to occur in the delicate and wrinkled parts of the skin, often starting from the crevices of the fingers, and can spread widely to the flexor side of the upper limbs, elbow fossa, anterior armpits, under the breasts, lower abdomen, gluteal groove, external genitalia, and inner thighs within 1-2 weeks. The upper side, etc., occasionally invade other parts, but not the head and face, but the baby's skin is relatively delicate, and scabies can easily invade the head and face of children. Mechanical irritation ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K47/34A61K31/167A61P33/14
Inventor 卞毓平
Owner 韩峰
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