Rosuvastatin calcium tablet and preparation process thereof
A technology for rosuvastatin calcium and a preparation process is applied in the field of rosuvastatin calcium-containing tablets and the preparation process thereof, and can solve the problems of stable rosuvastatin calcium tablets, high fluidity requirements, and poor particle size. Uniformity and other problems, to achieve the effect of easy industrialized large-scale production, solving the release stability, and simple preparation process
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[0033] Example 1
[0034]
[0035] Preparation process: Weigh rosuvastatin calcium, polystyrene maleic anhydride copolymer, and poloxamer 407, which have been passed through a 100-mesh sieve in the prescription, add them to absolute ethanol, suspend, and dry under reduced pressure at 40°C to remove the ethanol. The dried product is passed through an 80-mesh sieve, mixed uniformly with the prescribed amount of hydroxypropyl methylcellulose, sodium alginate, and microcrystalline cellulose passed through a 100-mesh sieve, and then mixed with magnesium stearate, and compressed.
Example Embodiment
[0036] Example 2
[0037]
[0038]
[0039] Preparation process: Weigh rosuvastatin calcium, polystyrene maleic anhydride copolymer, and poloxamer 407, which have been passed through a 100-mesh sieve in the prescription, add them to absolute ethanol, suspend, and dry under reduced pressure at 40°C to remove the ethanol. The dried product is passed through an 80-mesh sieve, mixed with the prescribed amount of hydroxypropyl methylcellulose, sodium alginate, and starch passed through a 100-mesh sieve, and then mixed with calcium stearate, and compressed.
Example Embodiment
[0040] Example 3
[0041]
[0042] Preparation process: Weigh rosuvastatin calcium, polystyrene maleic anhydride copolymer, and poloxamer 407, which have been passed through a 100-mesh sieve in the prescription, add them to absolute ethanol, suspend, and dry under reduced pressure at 40°C to remove ethanol The dried product is passed through an 80-mesh sieve, mixed with the prescribed amount of hydroxypropyl methylcellulose, sodium alginate, and mannitol that has passed through a 100-mesh sieve, and then mixed with sodium stearate fumarate and compressed.
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