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Telmisartan hydrochlorothiazide tablet and preparation method thereof

A technology for chlorothiazide tablets and telmisartan is applied in the directions of pill delivery, pharmaceutical formulations, medical preparations of inactive ingredients, etc. The effect of production cost, simple process and easy industrial production

Inactive Publication Date: 2021-04-13
SUZHOU CHUNGHWA CHEM & PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above technologies all adopt relatively complex preparation processes, resulting in high production costs, difficult quality control, and incapable of industrialized mass production

Method used

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  • Telmisartan hydrochlorothiazide tablet and preparation method thereof
  • Telmisartan hydrochlorothiazide tablet and preparation method thereof
  • Telmisartan hydrochlorothiazide tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035]

[0036]

[0037] Preparation Process:

[0038] (1) Pulverize Telmisartan Sodium and pass through a 100-mesh sieve;

[0039] (2) Hydrochlorothiazide is pulverized and processed, and crosses a 100-mesh sieve;

[0040] (3) Sodium alginate is pulverized and processed, and passed through a 100-mesh sieve;

[0041] (4) Mix telmisartan sodium, hydrochlorothiazide, sodium alginate, silicified microcrystalline cellulose, lactose 316, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate, and then directly compress the tablet , to be a drug-containing tablet;

[0042] (5) Coating with a gastric-soluble film coating premix, keeping the tablet bed temperature at 35-40° C., and increasing the coating weight by 3%.

Embodiment 2

[0044] prescription:

[0045]

[0046] Preparation process: with embodiment 1.

Embodiment 3

[0048] prescription:

[0049]

[0050]

[0051] Preparation process: with embodiment 1.

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Abstract

The invention discloses a telmisartan hydrochlorothiazide tablet and a preparation method thereof. The telmisartan hydrochlorothiazide tablet is prepared by coating a drug-containing element tablet, the drug-containing element tablet is prepared by uniformly mixing the following raw materials and auxiliary materials in percentage by mass: 13%-28% of telmisartan sodium, 2%-5% of hydrochlorothiazide, 2%-10% of a hydrophilic polymer material, 25%-40% silicified microcrystalline cellulose, 25%-40% lactose 316, 4%-6% of a disintegrating agent, 2%-4% of an adhesive and 0.5%-1.5% of a lubricant. According to the invention, by adding the hydrophilic polymer material, when the tablet is in an environment with high humidity, the hydrophilic polymer material absorbs water and plays a good role in protecting the raw materials, and besides, the process is simple and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for treating hypertension, in particular to a telmisartan hydrochlorothiazide tablet and a preparation method thereof. Background technique [0002] Telmisartan (telmisartan), the chemical name is 4'-[(1,4'-dimethyl-2'-propyl[2,6'-di-1H-benzimidazole]-1'-yl) Methyl]-[1,1'-biphenyl]-2-carboxylic acid, the molecular formula is C 33 h 30 N 4 o 2 , molecular weight: 514.63, the structural formula is as follows: [0003] [0004] Hydrochlorothiazide, chemical name 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide, molecular formula C 7 h 8 ClN 3 o 4 S 2 , the molecular weight is 297.74, and the structural formula is as follows: [0005] [0006] Telmisartan is an angiotensin II receptor blocker (ARB), which can selectively bind to the angiotensin II AT1 receptor subtype for a long time ...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/38A61K47/26A61K31/549A61K31/4184A61P9/12
CPCA61K9/2018A61K9/2054A61K9/28A61K31/4184A61K31/549A61P9/12A61K2300/00
Inventor 李丹
Owner SUZHOU CHUNGHWA CHEM & PHARMA IND
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