Composition with anti-acne effect and its application and preparation
A composition and acne technology, applied in the field of medicine, can solve problems such as unsatisfactory curative effect
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Embodiment 1
[0033] Example 1 Test of acne removal effect
[0034] Test group: The test is divided into placebo group, single drug group, test group and control group. The single drug components are licorice single drug group, white peony single drug group, Danshen single drug group, and zinc citrate group; test components For test groups 1 to 5, test groups 1 to 5 ate combinations 1 to 5, and the formulas of combinations 1 to 5 are shown in Table 1. The control group ate a commercially available acne-removing capsule. The application scheme of each group is shown in Table 2.
[0035] Test method: 165 patients were selected for treatment in the dermatology department, all of whom were voluntary subjects with clinical acne Ⅰ-Ⅲ degree. They were randomly divided into 11 groups with 15 people in each group. The test group took the test product according to the recommended method and dosage, 750mg of oral drug per day, and the control group took the marketed product according to the recommended d...
Embodiment 2
[0064] Example 2 Preparation of anti-acne tablets
[0065] The formula of the anti-acne tablets is shown in Table 7:
[0066] Table 7 The formula of anti-acne tablets
[0067]
[0068] Technological operation of preparing anti-acne tablets:
[0069] Weigh the formula vitamin B 6 , Vitamin A, pre-gelatinized starch pre-mixed for 5 minutes; then with the formula amount of Danshen extract, Radix Paeoniae Alba extract, Licorice extract, zinc citrate, maltodextrin, crospovidone, high substituted hydroxypropyl Cellulose, silicon dioxide, and magnesium stearate are put into a mixer and mixed for 20-30 minutes.
[0070] Use a tablet press to compress the above-mentioned mixture into tablets, 1 g / tablet, to obtain plain tablets.
[0071] Weigh the formula amount of coating agent and water, configure them to an appropriate solid content, and stir in the paddle pan for 30 to 45 minutes; after the stirring is completed, coat the plain tablets until the surface is basically filmed and the color is c...
Embodiment 3
[0072] Example 3 Preparation of anti-acne capsules
[0073] The formula of anti-acne capsules is shown in Table 8:
[0074] Table 8 The formula of anti-acne capsules
[0075]
[0076] The technological operation of preparing anti-acne capsules:
[0077] Weighing: Accurately weigh various materials according to the above-mentioned formula and reserve.
[0078] Sieve: Put vitamin B 6 Pass through a 60-mesh sieve, and then together with vitamin A powder, gradually premix with part of the pregelatinized starch; zinc citrate through a 60-mesh sieve; each Chinese medicine extract through a 40-mesh sieve.
[0079] Total mixing: Put the prepared materials and the materials that have been premixed and sieved into the three-dimensional mixer for total mixing for 30 minutes, until the color is uniform, then discharge.
[0080] Filling: Use 0# mold to fill with 0.45g / capsule. During the filling process, control the difference of grain weight within ±4.5%, and check the appearance of the capsule at an...
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