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Pharmaceutical composition for treating oral ulcer and preparation method thereof

A technology for oral ulcers and compositions, which is applied in the field of pharmaceutical compositions for treating oral ulcers, can solve problems such as being unfavorable to industrialization, cost control, complex components, and the like, and achieve a reliable preparation method, simple formulation, and easy-to-obtain medicinal material resources. Effect

Inactive Publication Date: 2015-06-10
张远强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned technical scheme is characterized by complex components, which is not conducive to industrialization and cost control

Method used

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  • Pharmaceutical composition for treating oral ulcer and preparation method thereof
  • Pharmaceutical composition for treating oral ulcer and preparation method thereof
  • Pharmaceutical composition for treating oral ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030] components

Dosage(kg)

American ginseng

5

Houttuynia cordata

25

Cassia

18

Honey (30% water content)

25

Mannitol (powder)

16.5

[0031] a) Weigh 5kg of American ginseng, grind it into powder, pass through a 24-mesh sieve, add 2 times of 60% ethanol solution to extract for 1.5 hours, extract 2 times, mix the extract twice, filter to obtain the filtrate, recover ethanol under reduced pressure, and concentrate to The relative density was 1.1, and the extract 1 was obtained and set aside.

[0032] b) Weigh 18kg cassia seeds, pulverize them, and pass through a 24-mesh sieve to obtain material 2, which is set aside.

[0033] c) Weigh 25kg of Houttuynia cordata, mix with material 2, add 3 times of purified water, soak for 30 minutes, decoct for 2 hours, decoct for 3 times, combine the extracts, filter to obtain the filtrate, concentrate to a relative density of 1.15, The extract ...

Embodiment 2

[0038] prescription:

[0039] components

Dosage(kg)

American ginseng

20

Houttuynia cordata

7

Cassia

5

Honey (30% water content)

7

Mannitol

10

microcrystalline cellulose

12

[0040] a) Weigh 20kg of American ginseng, grind it into powder, pass through a 30-mesh sieve, add 2 times of 75% ethanol solution to extract for 3 hours, extract 2 times, mix the extract twice, filter to obtain the filtrate, recover ethanol under reduced pressure, and concentrate When the relative density is 1.2, extract 1 is obtained and set aside.

[0041] b) Weigh 5kg cassia seeds, crush them, and pass through a 50-mesh sieve to obtain material 2, which is set aside.

[0042] c) Weigh 7kg of Houttuynia cordata, mix with material 2, add 3 times of purified water, soak for 20 minutes, decoct for 2 hours, decoct for 3 times, combine the extracts, filter to obtain the filtrate, concentrate to a relative density of 1.25, ...

Embodiment 3

[0047] prescription:

[0048] components

Dosage

American ginseng

8

Houttuynia cordata

20

Cassia

15

Honey (30% water content)

10

Mannitol

15

[0049] a) Weigh 8kg of American ginseng, grind it into powder, pass through a 50-mesh sieve, add 2 times of 65% ethanol solution to extract for 2.5 hours, extract 2 times, mix the extract twice, filter to obtain the filtrate, recover ethanol under reduced pressure, and concentrate When the relative density is 1.4, extract 1 is obtained and set aside.

[0050] b) Weigh 15kg cassia seeds, crush them, and pass through a 30-mesh sieve to obtain material 2, which is set aside.

[0051] c) Weigh 20kg of Houttuynia cordata, mix with material 2, add 3 times of purified water, soak for 38 minutes, decoct for 2.8 hours, decoct for 3 times, combine the filtrate to filter, concentrate to a relative density of 1.21, and obtain extract 3, spare.

[0052] d) Weigh 10kg of ho...

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Abstract

The invention discloses a pharmaceutical composition for treating oral ulcer and a preparation method thereof. The pharmaceutical composition contains the ingredients, namely panax quinquefolium, houttuynia cordata thunb, cassia seeds and honey. A preparation method of the pharmaceutical composition comprises the steps: (a) grinding panax quinquefolium of a certain ratio, sieving, adding ethanol to extract, filtrating, recovering the ethanol, and concentrating so as to obtain an extract 1 for later use; (b) grinding the cassia seeds of a certain ratio, and sieving so as to obtain a material 2 for later use; (c) mixing the houttuynia cordata thunb of a certain ratio with the material 2, adding purified water to soak, decocting, filtrating, and concentrating so as to obtain an extract 3 for later use; (d) mixing the honey of a certain ratio with purified water and mannitol according to a certain ratio, and carrying out freeze drying so as to obtain freeze-dried powder 4 for later use; (e) uniformly mixing the extract 1 and the extract 3, drying, crushing, and sieving so as to obtain dried powder 5 for later use; and (f) uniformly mixing the freeze-dried powder 4 and the dried powder 5 so as to obtain dried powder 6, wherein the dried powder 6 is prepared into a pharmaceutically-acceptable dosage form.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating oral ulcer and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Oral ulcer is a common oral disease, which is called aphthous ulcer in traditional Chinese medicine. It is a chronic inflammation characterized by repeated painful ulcers in the oral mucosa. It is manifested as single or multiple superficial ulcers. High, mainly manifested as single or multiple isolated round or oval superficial ulcers on the lips, cheeks, tongue, floor of the mouth, and soft palate, with neat edges and obvious blush, off-white or gray-yellow base, and severe burning pain. [0003] The pathogenesis of oral ulcers is complex, with obvious individual differences, and repeated attacks seriously affect the physical and mental health of patients. Most scholars believe that the occurrence of this disease is related to infection, abnormal immune function,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61P1/02A61K35/644
Inventor 张远强
Owner 张远强
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