Acid treatment agent, sample pretreatment method, kit and detection method for HIV detection

A technology of detection kit and treatment agent, applied in the field of acid treatment agent for HIV detection, can solve the problems of missed diagnosis or misdiagnosis, false positive, false negative, etc., and achieve the effect of improving detection sensitivity
CN104697830BActive Publication Date: 2018-06-15SHENZHEN NEW INDS BIOMEDICAL ENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN NEW INDS BIOMEDICAL ENG
Publication Date
2018-06-15

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Abstract

The invention discloses an acid treatment agent for HIV detection, a sample pretreatment method, a kit and a detection method, and belongs to the technical field of in vitro diagnosis and detection. The acid treatment agent is mainly composed of an organic acid solution with a concentration of 0.1-1.0mol / L and an inorganic acid solution with a concentration of 0.01-0.1mol / L, or an organic acid solution with a concentration of 0.1-1.2mol / L. The pH value of the acid treatment agent is 2.5-4.5. Using the above-mentioned acidic treatment agent, the p24 antigen and p24 antibody in the sample can be well separated. The HIV detection kit, the sample pretreatment method and the detection method using the above acidic treatment agent have the advantage of high sensitivity.
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Description

technical field

[0001] The invention relates to the technical field of in vitro diagnosis and detection, in particular to an acid treatment agent for HIV (human immunodeficiency virus) detection, a sample pretreatment method, a kit and a detection method. Background technique

[0002] After the HIV virus (human immunodeficiency virus) invades the human body, its surface glycoprotein gp120 binds to the cell surface receptor protein CD4 with high affinity and adsorbs to the host cell; gp120 interacts with the host cell surface co-receptor to make the virus and The host cell membrane is closer; gp41 produces a series of conformational changes, and its N-terminal fusion peptide fragment is inserted into the host cell membrane, resulting in the final fusion of the viral envelope and the cell membrane, and viral RNA enters the cell. After HIV infection, viral RNA can be detected first, then the viral p24 antigen, and finally antibodies. According to the characteristics of HIV gen...

Claims

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