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A kind of preparation method of medicinal hydroxypropyl starch capsule

A technology of hydroxypropyl starch and capsules, which is applied in the field of preparation of starch-based capsules. It can solve the problems of high equipment requirements, long time consumption, and the production of microorganisms, and achieve high transparency, short defoaming time, and few reaction by-products. Effect

Active Publication Date: 2017-08-29
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because modified starch usually uses alkaline substances when using traditional technology for etherification treatment, it is easy to produce by-products, and at the same time it requires high equipment, and it is easy to absorb water and produce microorganisms during storage, which makes the properties of capsules poor.
Static defoaming takes a long time and the effect is poor, while decompression defoaming or centrifugal defoaming, although the effect is better, but the operation is more cumbersome, which brings some troubles to the process

Method used

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  • A kind of preparation method of medicinal hydroxypropyl starch capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Starch etherification: After blending propylene oxide and catalyst in the dispersion medium, add food-grade starch. The ratio of the volume of propylene oxide to the mass of starch is 1.5ml: 1.0g, and keep stirring to make it fully react.

[0028] (2) Preparation of starch slurry glue: add water to the sol tank, raise the temperature to 30°C, add the starch glue prepared in step (1), raise the temperature to 50°C, add a reinforcing agent, and stir to obtain the starch slurry glue;

[0029] (3) Defoaming and impurity removal: Add 2 times the volume of ethanol to the starch slurry and wash it 3 times to remove unreacted by-products such as propylene oxide and propylene glycol, and finally add ethanol and let it stand for a while until the glue is removed. Discard after soaking completely;

[0030] (4) Capsule preparation: the defoamed starch slurry glue solution in the above step (3) is prepared by a conventional dipping method to obtain a starch hollow capsule;

Embodiment 2

[0032] (1) Starch etherification: After blending propylene oxide and catalyst in the dispersion medium, add food-grade starch. The ratio of the volume of propylene oxide to the mass of starch is 2ml: 1.0g, and keep stirring to make it fully react.

[0033] (2) Preparation of starch paste glue: add water to the sol tank, raise the temperature to 35°C, add the starch glue prepared in step (1), heat up to 55°C, add a reinforcing agent, and stir to obtain the starch paste glue;

[0034] (3) Defoaming and impurity removal: Add 3 times the volume of ethanol to the starch slurry and wash it 4 times to remove by-products such as unreacted propylene oxide and propylene glycol, and finally add ethanol and let it stand for a period of time until the glue is removed. Discard after soaking completely;

[0035] (4) Capsule preparation: the defoamed starch slurry glue solution in the above step (3) is prepared by a conventional dipping method to obtain a starch hollow capsule;

Embodiment 3

[0037] (1) Starch etherification: After blending propylene oxide and catalyst in the dispersion medium, add food-grade starch. The ratio of the volume of propylene oxide to the mass of starch is 2.5ml: 1.0g. Stir continuously to make it fully react.

[0038] (2) Preparation of starch paste glue: add water to the sol tank, raise the temperature to 40°C, add the starch glue prepared in step (1), heat up to 50°C, add a reinforcing agent, and stir to obtain the starch paste glue;

[0039] (3) Defoaming and impurity removal: Wash the starch slurry glue with 3 times the volume of ethanol for 5 times to remove unreacted by-products such as propylene oxide and propylene glycol, and finally add ethanol and let stand for a period of time until the glue is detached. Discard after soaking completely;

[0040] (4) Capsule preparation: the defoamed starch slurry glue solution in the above step (3) is prepared by a conventional dipping method to obtain a starch hollow capsule;

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Abstract

The invention belongs to the technical field of medicine preparation and relates to a preparation method for producing starch-based capsules. The method specifically includes the following steps: starch etherification, gelatinization, defoaming, impurity removal, gel-dipping molding and the like. The hydroxypropyl starch capsule prepared by the invention not only has the advantages of smooth surface, high transparency, short disintegration time limit, etc., but also simplifies the production process, saves production cost, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of starch-based capsules, more specifically, a method for producing starch capsules by etherifying starch, gelatinization, defoaming, impurity removal, and dipping in gelatin. Background technique [0002] Capsules are widely used in medicine, health products and functional food industries. Traditional capsules mostly use gelatin produced by hydrolysis of animal skin and collagen as the capsule shell material, which inevitably has animal protein residues, which are prone to cross-linking with aldehyde-containing drugs, resulting in drug deterioration and other adverse effects result. In addition, gelatin of animal origin is unacceptable to vegetarians and people of religious belief. Therefore, the application and promotion of gelatin capsules are also limited to a large extent, and it is an urgent task to find vegetable capsules to replace gelatin capsules. [0003] As a renewable plant resource with a w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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