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A kind of preparation method of antifungal natural active substance

A natural active substance and antifungal technology, applied in botany equipment and methods, antifungal agents, chemicals for biological control, etc., can solve flammability, unsafe storage, transportation and use, low effective utilization rate, etc. problems, to achieve the effect of easy maintenance and cleaning, avoiding heat-labile components, and rapid and complete extraction

Active Publication Date: 2017-09-29
诸暨睿祥五金工具有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the emulsifiable concentrate contains organic solvents, it is not only toxic to humans and animals, but also pollutes the environment, and is flammable, so it is unsafe in storage, transportation and use. It has been banned from being used on vegetables and fruit trees abroad.
Although the powder can be sprayed and used directly, it is easy to drift and pollute the environment due to the lack of water, the effective utilization rate is low, and the drug effect period is relatively short

Method used

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  • A kind of preparation method of antifungal natural active substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Grinding and mixing: Grind the dry matter of Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins into coarse powder, pass through a 20-mesh sieve, and then mix according to the weight ratio of 2:2:1. (2) Extraction: put the dried Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins in the container of the crushing extractor, add 95% aqueous ethanol equivalent to 8 times the weight ratio of the raw materials, and carry out tissue crushing and extraction at room temperature twice , the extraction time is 3 minutes. (3) Flash concentration: Suction filter the extract, discard the filter residue, and flash concentrate the obtained extract to 1 / 6 of the original volume by using a vacuum thin film concentration device below 70°C. (4) Preparation of ether extraction part: disperse the concentrated solution into water, the amount of water used is one-third of the volume of the concentrated solution. Extract with diethyl ether for 3 times, the amount of eac...

Embodiment 2

[0034] (1) Grinding and mixing: Grind the dry matter of Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins into coarse powder, pass through a 20-mesh sieve, and then mix according to the weight ratio of 2:2:1. (2) Extraction: Put the dried Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins in the container of the crushing extractor, add 95% aqueous ethanol equivalent to 6 times the weight ratio of raw materials, and carry out tissue crushing and extraction at room temperature for 3 times , the extraction time is 2 minutes. (3) Flash concentration: Suction filter the extract, discard the filter residue, and flash concentrate the obtained extract to 1 / 6 of the original volume by using a vacuum thin film concentration device below 70°C. (4) Preparation of ether extraction part: disperse the concentrated solution into water, the amount of water used is one-third of the volume of the concentrated solution. Extract with diethyl ether 4 times, the amount of each ...

Embodiment 3

[0036] (1) Grinding and mixing: Grind the dry matter of Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins into coarse powder, pass through a 20-mesh sieve, and then mix according to the weight ratio of 2:2:1. (2) Extraction: Put the dried Xiaoguanxun, Ledang Zanthoxylum bungeanum, and Wedelia twins in the container of the broken extractor, add 95% aqueous ethanol equivalent to 10 times the weight ratio of the raw materials, and carry out tissue crushing and extraction at room temperature twice , the extraction time is 3 minutes. (3) Flash concentration: Suction filter the extract, discard the filter residue, and use a vacuum thin-film concentration device to flash-concentrate the obtained extract below 70°C to 1 / 7 of its original volume. (4) Preparation of ether extraction part: disperse the concentrated solution into water, the amount of water used is one-third of the volume of the concentrated solution. Extract with diethyl ether 5 times, the amount of each time ...

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Abstract

The invention discloses a preparation method of an antifungal natural active substance, which belongs to the technical field of natural plant preparations. It is characterized in that it comprises the following steps: 1) crushing and mixing; 2) extraction; 3) flash concentration; 4) preparation of ether extraction part; 5) preparation of ethyl acetate extraction part; 6) diethyl ether extract in step 4) The dry powder is mixed with the ethyl acetate extract dry powder in step 5) to obtain the antifungal natural active substance. The preparation method of the above-mentioned antifungal natural active substance, the extracts are respectively concentrated in vacuum to obtain ether extract and ethyl acetate extract, these two extraction parts have strong anti-phytopathogenic fungi and superficial fungal infection of human body It can be used as a botanical fungicide for the prevention and treatment of fungal infections and human skin fungal infections.

Description

technical field [0001] The invention belongs to the technical field of natural plant preparations, in particular to a preparation method of antifungal natural active substances. Background technique [0002] Fungal infection can be divided into two types: superficial fungal infection and deep fungal infection. Superficial infection is caused by ringworm fungus invading the skin, hair, fingernails and other body surface parts. The incidence rate is high and it is harmful to a certain extent. Deep fungal infection is caused by candida and cryptococcus invading internal organs and deep tissues, with low incidence and great harm. At present, the drugs commonly used to prevent fungal infections, like other chemical pesticides, have the disadvantages of toxicity and side effects, are difficult to degrade, and are prone to drug resistance, posing a great threat to the ecological environment and human health. [0003] Plants are a natural treasure house of biologically active compo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61P31/10A01N65/36A01P3/00
Inventor 袁珂蔡荣荣周梦佳戈玮琛陈明发蒋志龙
Owner 诸暨睿祥五金工具有限公司
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