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Combined medicine composition with candida-resistant effect, preparing method of combined medicine composition, preparation of combined medicine composition and application of globeflower ethanol extract

A technology for extracting Candida albicans and ethanol, applied in the field of medicine, can solve the problem that the antifungal effect of nasturtium lotus has not been reported in literature, etc., and achieve the effects of improving the immune function of the body, reducing the mortality rate, and controlling the quality.

Active Publication Date: 2015-08-19
河北百善医药科技有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, it is mainly used for the treatment of cold, fever, tonsillitis, pharyngitis, urinary tract infection, etc., but there is no literature report on the antifungal effect of nasturtium

Method used

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  • Combined medicine composition with candida-resistant effect, preparing method of combined medicine composition, preparation of combined medicine composition and application of globeflower ethanol extract
  • Combined medicine composition with candida-resistant effect, preparing method of combined medicine composition, preparation of combined medicine composition and application of globeflower ethanol extract
  • Combined medicine composition with candida-resistant effect, preparing method of combined medicine composition, preparation of combined medicine composition and application of globeflower ethanol extract

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Embodiment 1

[0027] Example 1: A combined drug combination with anti-Candida albicans effect:

[0028] A combined drug combination of anti-Candida albicans effect, including the former drug of fluconazole, wherein, the combined drug combination also includes the ethanol extract of Trollica chinensis, wherein the weight ratio of fluconazole and the ethanol extract of Trollius chinensis is 1:2.5;

[0029] Described nasturtium ethanol extract is prepared by the following method:

[0030] After the nasturtium is dried and crushed, add 70% ethanol at a ratio of 1g:20ml, extract twice in a water bath at 70°C, each time for 2h, filter, combine the extracts, recover ethanol, and dry the extract after recovering ethanol in a water bath at 70°C. That is the ethanol extract of Trollus chinensis.

[0031] The beneficial effects of a combined drug combination with anti-Candida albicans effect of the present invention and the effect of the Trollica ethanol extract on enhancing the anti-Candida albica...

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Abstract

The invention provides a combined medicine composition with a candida-resistant effect, a preparing method of the combined medicine composition, a preparation of the combined medicine composition and application of a globeflower ethanol extract, and belongs to the technical field of medicine. The combined medicine composition comprises fluconazole raw medicine and the globeflower ethanol extract, wherein the weight ratio of the fluconazole raw medicine to the globeflower ethanol extract is 1:2.5. The combined medicine composition has the following steps that the synergistic interaction and the advantage complementation are realized; the effect is obvious; safety is realized; the antibacterial effect of the fluconazole can be enhanced through the globeflower ethanol extract; the consumption and the adverse reaction of the fluconazole are reduced; in addition, the drug resistance of the candida on the fluconazole can be reduced; the antimicrobial activity is enhanced; the organism immune function and the disease-resistant capability can be improved through the globeflower ethanol extract; no toxic or side effect is discovered when the fluconazole raw medicine and the globeflower ethanol extract are combined to be applied.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a joint drug combination for anti-candida albicans, its preparation method and dosage form, and the application of the ethanol extract of nasturtium. Background technique [0002] Candida vaginitis is a common gynecological disease in women. A large number of studies have shown that 85%-90% of infections are caused by Candida albicans. Candida albicans is the main conditional pathogen of the human body, and people with low immune function are prone to disease. At present, azole antifungal drugs are mostly used clinically for candidal vaginitis, but with the extensive application of them, drug resistance to azole drugs gradually appears, resulting in reduced or ineffective drug efficacy. Therefore, it is very necessary to find drugs or methods to reduce the drug resistance of Candida albicans and increase the curative effect of azole drugs. [0003] Trollius chinen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P15/02A61P31/10A61K31/4196
Inventor 韩志强韩淑英王明泽王志璐王潇颖
Owner 河北百善医药科技有限公司
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