An antibacterial polyurethane medical device, its preparation method, and an antibacterial indwelling needle peripheral catheter
A medical device, polyurethane-based technology, applied in catheters and other directions, can solve the problems of easy peeling off of the coating and low safety
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[0033] The present invention provides a kind of preparation method of antibacterial type polyurethane medical device, comprises the following steps:
[0034] A) mixing a polyurethane medical device with a dopamine solution to obtain a polyurethane medical device with a polydopamine layer attached to its surface;
[0035] B) mixing the polyurethane medical device with a polydopamine layer attached to the surface obtained in the step A) with a silver nitrate solution, and reacting to obtain a polyurethane medical device with nano silver loaded on the surface;
[0036] C) mixing the polyurethane medical device loaded with nano-silver on the surface obtained in the step B) with the amino silicone oil solution, and reacting to obtain an antibacterial polyurethane medical device.
[0037] The coating in the antibacterial polyurethane medical device obtained by the preparation method provided by the invention has good adhesion on the surface of the substrate, is not easy to fall off,...
Embodiment 1
[0059] Prepare a Tris-HCl buffer solution with a concentration of 0.01mol / L (the buffer solution is an aqueous solution of trishydroxymethylaminomethane and hydrochloric acid), then dissolve dopamine in the Tris-HCl buffer solution, and prepare a dopamine with a concentration of 1.5mg / mL Solution, the control solution pH value is 8.5;
[0060] Immerse the peripheral catheter of the polyurethane indwelling needle in the dopamine solution prepared above, control the reaction temperature at 35°C, stir and react for 25 hours, take it out and wash it, and obtain the peripheral catheter of the polyurethane indwelling needle coated with polydopamine film;
[0061] Put the catheter prepared by the above reaction into an aqueous solution of silver nitrate with a concentration of 0.05mol / L, take it out after immersion for 9 hours, rinse it with water, and dry it under vacuum at 40°C to obtain a polyurethane indwelling tube with a layer of nano-silver on the surface. Needle Peripheral Ca...
Embodiment 2
[0067] Prepare a Tris-HCl buffer solution with a concentration of 0.01mol / L (the buffer solution is an aqueous solution of trishydroxymethylaminomethane and hydrochloric acid), then dissolve dopamine in the Tris-HCl buffer solution, and prepare a dopamine solution with a concentration of 2mg / mL , the control solution pH value is 10;
[0068] Immerse the peripheral catheter of the polyurethane indwelling needle in the dopamine solution prepared above, control the reaction temperature at 35°C, stir and react for 25 hours, take it out and wash it, and obtain the peripheral catheter of the polyurethane indwelling needle coated with polydopamine film;
[0069] Put the catheter prepared by the above reaction into an aqueous solution of silver nitrate with a concentration of 0.05mol / L, take it out after immersion for 9 hours, rinse it with water, and dry it under vacuum at 40°C to obtain a polyurethane indwelling tube with a layer of nano-silver on the surface. Needle Peripheral Cath...
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