Enteric-coated preparation containing notoginseng triterpenes and preparation method and application of enteric-coated preparation

A technology of Panax notoginseng saponins and enteric-coated preparations, which is applied in the field of enteric-coated preparations of Panax notoginseng saponins and its preparation, which can solve the problems of low dosing rate and sticky pills, and achieve good integrity, short use time and controllable wide range of effects

Active Publication Date: 2015-11-11
HARBIN ZHENBAO PHARMA
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In the prior art about enteric-coated preparations of Panax notoginseng saponins, most of the process methods are extrusion spheronization method and non-porous coating pan preparation method. During the preparation process, it is easy to cause problems such as sticky pills and low drug application rate, which will affect the content of the pills. Indicators for evaluating drug quality such as release rate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Enteric-coated preparation containing notoginseng triterpenes and preparation method and application of enteric-coated preparation
  • Enteric-coated preparation containing notoginseng triterpenes and preparation method and application of enteric-coated preparation
  • Enteric-coated preparation containing notoginseng triterpenes and preparation method and application of enteric-coated preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Prescription for tablet core:

[0066]

Dosage

Panax notoginseng total saponins (neither dry nor pure)

40g

Blank core (sucrose)

120g

hypromellose

3.2g

Low-substituted hydroxypropyl cellulose

8g

Talc powder

4.8g

purified water

up to 500ml

[0067] 2. Preparation process

[0068] 1) Preparation of drug solution

[0069] Take 70% of the prescribed amount of purified water, heat it to 50°C, slowly add the prescribed amount of hypromellose and stir continuously until it dissolves, then add low-substituted hypromellose and total saponins of Panax notoginseng in sequence, and continue stirring until the total amount of Panax notoginseng After the saponin is completely dissolved, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0070] 2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized b...

Embodiment 2

[0076] 1. Prescription for tablet core:

[0077]

Dosage

Panax notoginseng total saponins (neither dry nor pure)

40g

Blank core (sucrose)

80g

hypromellose

2g

Crospovidone

4g

Talc powder

3.2g

purified water

up to 500ml

[0078] 2. Preparation process

[0079] 1) Preparation of drug solution

[0080] Take 70% of the prescription amount of purified water, heat it to 50°C, slowly add the prescription amount of hypromellose and stir until it dissolves, then add crospovidone and Panax notoginseng saponins in turn, and continue stirring until Panax notoginseng saponins After it is completely dissolved, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0081] 2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized bed, and spray it on the surface of the blank core. The ratio of the total saponins of no...

Embodiment 3

[0087] 1. Prescription for tablet core:

[0088]

Dosage

Panax notoginseng total saponins (neither dry nor pure)

40g

[0089] Blank core (sucrose)

40g

hypromellose

2.8g

sodium starch glycolate

6g

Talc powder

4g

purified water

up to 500ml

[0090] 2. Preparation process

[0091] 1) Preparation of drug solution

[0092] Take 70% of the prescribed amount of purified water, heat it to 50°C, slowly add the prescribed amount of hypromellose and stir until it dissolves, then add sodium starch glycolate and total saponins of Panax notoginseng in sequence, and continue stirring until the total saponins of Panax notoginseng are completely dissolved. After dissolving, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0093]2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized bed, and spray it...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an enteric-coated preparation containing notoginseng triterpenes and a preparation method of the enteric-coated preparation. The enteric-coated preparation containing notoginseng triterpenes comprises an upper pill core, an isolation layer and an enteric-coated layer, wherein the upper pill core is sequentially coated with the isolation layer and the enteric-coated layer. The pill core comprises, by weight, 40 parts of notoginseng triterpenes, 40-120 parts of blank pellets, 4-8 parts of disintegrant, 2-3.5 parts of adhesive and 3-5 parts of talcum powder. The isolation layer coating is additionally arranged between the enteric-coated layer and the upper pill core so as to enable the surface of the upper pill core to be more smooth, coating is complete, and an enteric coating is easily obtained; notoginseng triterpenes has certain moisture absorption, and the stability of pellets can be improved by additionally arranging the isolation layer coating. In addition, a fluidized bed bottom spraying method is adopted, through formulation optimization, the problem of pellet adhesion caused by the physicochemical property of notoginseng triterpenes is successfully solved, and the high-quality enteric-coated preparation is obtained.

Description

technical field [0001] The invention relates to traditional Chinese medicine preparations, in particular to an enteric-coated preparation of Panax notoginseng saponins, a preparation method and application thereof. Background technique [0002] Panax notoginseng saponins (Notoginsengtriterpenes), cure mainly blood circulation promoting and blood stasis dispelling, dredging channels and activating collaterals. It has the effect of inhibiting platelet aggregation and increasing cerebral blood flow, and is used for cerebrovascular sequelae, central retinal vein occlusion, anterior chamber hemorrhage, etc. [0003] The total saponins of Panax notoginseng are extracted from high-quality Panax notoginseng according to the extraction and separation technology. Among them, ginsenoside Rg 1 and Rb 1 Accounting for about 60-70%, it is the main active ingredient that exerts pharmacological effects. [0004] Currently, there are Xuesaitong Tablets, Xuesaitong Capsules, Xuesaitong Gr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/258A61K9/62A61K9/58A61P9/00
Inventor方同华王维龙贾文娟周广红韩冰王博于征帆
OwnerHARBIN ZHENBAO PHARMA