Drug material with hypnotic effect and preparation method thereof

A drug and a technology of action, applied in the field of pharmaceutical raw materials with hypnotic effect and preparation thereof, can solve the problems such as information that has not yet been applied, the active ingredients and the mechanism of action are unclear, and achieve the effects of less side effects and broad application prospects.

Inactive Publication Date: 2015-11-18
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific active ingredients and mechanism of action in the sunflower sunflower are still unclear, and so far there is no information about

Method used

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  • Drug material with hypnotic effect and preparation method thereof
  • Drug material with hypnotic effect and preparation method thereof

Examples

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Effect test

preparation example Construction

[0014] A preparation method of a drug raw material with hypnotic effect, comprising the following steps:

[0015] Step 1. Crush the roots, leaves, stems, flowers or the whole plant of Sunflower sunflower, add deionized water 10 times its mass and soak for 48 hours, filter with Buchner funnel, and collect the filtrate; Soak in water and repeat suction filtration 4 to 5 times; mix the filtrate obtained by suction filtration after multiple extractions to obtain mixed solution A, and set aside;

[0016] Step 2: After extracting the mixed solution A of the goldenflower sunflower material, the remaining material is vacuum-dried at low temperature, and then added to ethanol with 10 times its mass to soak for 24 hours for extraction, suction filtration through a Buchner funnel, and the filtrate is collected; Ethanol is recovered by pressure distillation; the recovered ethanol is added to the filter residue obtained by suction filtration to soak for extraction, the extraction is repeat...

Embodiment 1

[0021] A preparation method of a drug raw material with hypnotic effect, comprising the following steps:

[0022] Step 1. Crush the roots, leaves, stems, flowers or the whole plant of Sunflower sunflower, add deionized water 10 times its mass and soak for 48 hours, filter with Buchner funnel, and collect the filtrate; Water immersion and repeated suction filtration 4 times; the filtrate obtained by suction filtration after multiple extractions was mixed to obtain a mixed solution A, which was set aside;

[0023] Step 2: After extracting the mixed solution A of the goldenflower sunflower material, the remaining material is vacuum-dried at low temperature, and then added to ethanol with 10 times its mass to soak for 24 hours for extraction, suction filtration through a Buchner funnel, and the filtrate is collected; Recover ethanol by pressure distillation; add recovered ethanol to the filter residue obtained by suction filtration to soak for extraction, repeat the extraction 4 t...

Embodiment 2

[0026] A preparation method of a drug raw material with hypnotic effect, comprising the following steps:

[0027] Step 1. Crush the roots, leaves, stems, flowers or the whole plant of Sunflower sunflower, add deionized water 10 times its mass and soak for 48 hours, filter with Buchner funnel, and collect the filtrate; Water immersion and repeated suction filtration 5 times; the filtrate obtained by suction filtration after multiple extractions was mixed to obtain a mixed solution A, which was set aside;

[0028] Step 2. After extracting the golden flower sunflower material from the mixed solution A, the remaining material is vacuum-dried at low temperature, then added to ethanol with 10 times its mass and soaked for 24 hours for extraction, and the Buchner funnel is suction filtered to collect the filtrate; Distill under reduced pressure at 50°C Recover ethanol; add recovered ethanol to the filter residue obtained by suction filtration to soak for extraction, repeat the extrac...

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Abstract

The invention discloses a drug material with hypnotic effect and a preparation method thereof. The preparation method includes: smashing roots, leaves, stems and flowers or whole plants of abelmoschus manihot, adding deionized water for soaking, using a Buchner funnel for suction filtering, and collecting filtrate to obtain a mixed solution A; subjecting the rest of an abelmoschus manihot material after the mixed solution A is extracted to low-temperature vacuum drying, adding alcohol for soaking for extraction, using the Buchner funnel for suction filtering, and collecting filtrate to obtain a mixed solution B; mixing the mixed solution A and the mixed solution B, adding petroleum ether, ethyl acetate and n-butanol, mixing well, adding resveratrol, standing after being mixed well, using the Buchner funnel for suction filtering, and collecting filtrate; depressurizing, distilling and concentrating the collected filtrate to obtain the drug material. The drug material prepared by the method is remarkable in hypnotic effect, and is pure plant extract, thereby having small side effect on organism and having big influence on development of the field of medicine in the future.

Description

technical field [0001] The invention relates to a drug raw material with hypnotic effect, in particular to a drug raw material with hypnotic effect and a preparation method thereof. Background technique [0002] Insomnia is a clinical frequently-occurring disease with complex etiology and easy recurrence. The sedative-hypnotics of western medicine and western medicine commonly used for domestic and international treatment all have certain side effect and dependence at present. Golden flower sunflower is a precious nourishing Chinese medicinal material in my country. Modern medicine has proved that golden flower sunflower has many functions such as regulating blood pressure, lowering blood sugar, regulating blood lipids, antibacterial and anti-inflammatory, inhibiting tumor cell growth, nourishing yin and kidney, strengthening muscles and bones, and delaying aging. After extensive systematic research, it has been proved that the main components of goldenflower sunflower are ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A23L1/29A61P25/20A23L33/00
Inventor 李欣乔家驹庞新跃李鑫玲唐子辰
Owner HENAN UNIV OF SCI & TECH
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