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Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation

A technology of active ingredients and compound preparations, applied in the field of compound preparations of active ingredients of traditional Chinese medicine for the treatment of lung cancer and breast cancer and its preparation, can solve the problems of large toxic and side effects, unsatisfactory curative effect, and low curative effect of cancer

Inactive Publication Date: 2015-11-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented medicinal herb extracts have been found effective for prevention or treatment of various types of diseases such as lungs disease and breast carcinoma caused by harmful substances like chemical agents. These drugs are called Active Ingredients Compounds ("AGC").

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways to improve or develop treatments against diseases like cancer caused by viruses without causing harmful side effectes.

Method used

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  • Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation
  • Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation
  • Lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and preparation method of lung cancer and breast cancer compound preparation

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Embodiment 1

[0027] Embodiment 1: A kind of active ingredient compound preparation of Chinese medicine for the treatment of lung cancer and breast cancer, consisting of 1 part (10 mg) of erianin, 1 part (10 mg) of taxol, 1 part (10 mg) of bufoling (10 mg) and brucein D1 Part (10mg) is made, wherein the preparation method of liposome is as follows:

[0028] (1) The preparation materials and proportions of the active ingredient compound liposome of traditional Chinese medicine are as follows: the mass ratio of lecithin to mPEG2000-DSPE (amphipathic polyethylene glycol 2000-distearoylphosphatidylethanolamine) is 10:1, and The mass ratio of cholesterol is 10:1, and the mass ratio of the active ingredient compound drug of traditional Chinese medicine is 30:1.

[0029] (2) The preparation method of the compound liposome active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 90mL of PBS buffer solution with pH 7.4 in an eggplant-sh...

Embodiment 2

[0033] Embodiment 2: a kind of Chinese medicine active ingredient compound preparation for the treatment of lung cancer and breast cancer, by Erianin 2 parts (20mg), taxol 2 parts (20mg), bufalin 2 parts (20mg) and brucein D2 Part (20mg) is made, wherein the preparation method of liposome is as follows:

[0034] (1) The preparation materials and proportions of the active ingredient compound liposome of traditional Chinese medicine are as follows: the mass ratio of lecithin to mPEG2000-DSPE (amphipathic polyethylene glycol 2000-distearoylphosphatidylethanolamine) is 10:1, and The mass ratio of cholesterol is 10:1, and the mass ratio of the active ingredient compound drug of traditional Chinese medicine is 30:1.

[0035] (2) The preparation method of the compound liposome active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 180mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, preheat in a const...

Embodiment 3

[0039] Embodiment 3: a kind of Chinese medicine active ingredient compound preparation for the treatment of lung cancer and breast cancer, by Erianin 3 parts (30mg), taxol 3 parts (30mg), bufoling 3 parts (30mg) and brucein D3 Part (30mg) is made, wherein the preparation method of liposome is as follows:

[0040] (1) The preparation materials and proportions of the active ingredient compound liposome of traditional Chinese medicine are as follows: the mass ratio of lecithin to mPEG2000-DSPE (amphipathic polyethylene glycol 2000-distearoylphosphatidylethanolamine) is 10: 1.2, and The mass ratio of cholesterol is 10:1.2, and the mass ratio of the active ingredient compound drug of traditional Chinese medicine is 30:0.8.

[0041] (2) The preparation method of the compound liposome active ingredient of traditional Chinese medicine is as follows: prepare by ethanol injection method, accurately measure 270mL of PBS buffer solution with pH 7.4 in an eggplant-shaped bottle, preheat in...

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Abstract

The invention discloses a lung cancer and breast cancer treatment compound preparation containing active ingredients of traditional Chinese medicine and a preparation method of the lung cancer and breast cancer compound preparation. The lung cancer and breast cancer treatment compound preparation is made from erianin, taxol, bufalin and bruceine D according to a certain weight ratio. According to the preparation method, liposomes are prepared according to an ethyl alcohol injection method or dropping pills are prepared by taking polyethylene glycol as a base material to obtain the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine. The form of the compound preparation is compound liposomes and compound dripping pills. According to animal in-vivo anticancer pharmacological experiments, the lung cancer and breast cancer treatment compound preparation containing the active ingredients of the traditional Chinese medicine has obvious inhibiting effect on growth of lung cancer and breast cancer and has higher anticancer activity than chemotherapeutic drug 5-fluorouracil.

Description

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Claims

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Application Information

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Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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