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Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof

A technology of inhibiting melanin and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of long-term use hazards and obvious side effects, etc., and achieve powerful scavenging of oxygen free radicals, significant effect, and reasonable component formula Effect

Inactive Publication Date: 2015-12-16
GUANGZHOU HUANYA COSMETIC SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Many existing chemical synthetic agents control the production of melanin by inhibiting the activity of tyrosinase, which are satisfactory in terms of stability and effect, but have obvious side effects, and there are potential hazards in long-term use.

Method used

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  • Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof
  • Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof
  • Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A traditional Chinese medicine composition for inhibiting the formation of melanin, made from the following Chinese herbal medicine components in parts by weight in the formula table:

[0036] components

parts by weight

[0037] Ginkgo biloba

35

Mint leaf

5

raspberry

30

Chrysanthemum

10

Polygonatum odoratum

10

Ophiopogon japonicus

10

[0038] The preparation method is as follows:

[0039] Crush the Chinese herbal medicine components in the formula table, pass through an 80-mesh sieve, and mix evenly to obtain a medicinal material mixture. Add pure water 6 times the total weight of the medicinal material mixture, and extract homogeneously under high pressure for 30 minutes at an extraction pressure of 50 MPa. 0.3μm microporous filtration, concentrate the filtrate membrane to 10-15% of the original volume, wash the macroporous resin column with resin model D101 or AB-8 until...

Embodiment 2

[0041] A traditional Chinese medicine composition for inhibiting the formation of melanin, made from the following Chinese herbal medicine components in parts by weight in the formula table:

[0042] components

parts by weight

Ginkgo biloba

15

Mint leaf

5

raspberry

40

Chrysanthemum

10

Polygonatum odoratum

20

Ophiopogon japonicus

10

[0043] The preparation method is as follows:

[0044] Pulverize the Chinese medicinal material components in the formula table, pass through a 100-mesh sieve, and mix evenly to obtain a medicinal material mixture. Add 30% ethanol aqueous solution that is 12 times the total weight of the medicinal material mixture, and extract homogeneously under high pressure for 15 minutes at an extraction pressure of 70Mpa. Combine the extracts, Use a microporous filter with a pore size of 0.2 μm, concentrate the filtrate membrane to recover ethanol until it has no alcohol s...

Embodiment 3

[0046] A traditional Chinese medicine composition for inhibiting the formation of melanin, made from the following Chinese herbal medicine components in parts by weight in the formula table:

[0047] components

parts by weight

Ginkgo biloba

25

Mint leaf

5

raspberry

25

Chrysanthemum

20

Polygonatum odoratum

20

Ophiopogon japonicus

5

[0048] The preparation method is as follows:

[0049]Pulverize the Chinese medicinal material components in the formula table, pass through a 120-mesh sieve, and mix evenly to obtain a medicinal material mixture, add 70% ethanol aqueous solution 20 times the total weight of the medicinal material mixture, extract homogeneously under high pressure for 10 minutes, and extract at a pressure of 30 MPa, and combine the extracts. Use a microporous filter with a pore size of 0.5 μm, concentrate the filtrate membrane to recover ethanol until it has no alcohol smell, ad...

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Abstract

The invention relates to a traditional Chinese medicine combination for inhibiting melanin generation. The traditional Chinese medicine combination is prepared with, by weight, 15-35 parts of gingko leaf, 5-50 parts of mint leaf, 15-40 parts of raspberry, 10-35 parts of Hangzhou white chrysanthemum, 10-30 parts of fragrant solomonseal rhizome and 5-40 parts of dwarf lilyturf tuber. The traditional Chinese medicine combination is reasonable in composition, can realize synergistic effect, can efficiently remove oxygen radicals and inhibit tyrosinase activity, is ultraviolet-resistant, capable of accelerating renewal of skin superficial cells, improving skin immunity and delaying skin aging, and cosmetics prepared with the traditional Chinese medicine combination are stable in property has remarkable effect on whitening and brightening skin.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for inhibiting the formation of melanin, its preparation method and its application in cosmetics. Background technique [0002] With the increase of age, brown spots, freckles and pigmentation after sun exposure will appear on the skin, increase or not disappear easily, which has become a trouble for middle-aged and elderly people, especially women. [0003] Skin coloring is closely related to the pituitary gland, an endocrine gland in the human body. The pituitary gland has two melanocyte-stimulating hormones (MSH), α-MSH and β-MSH. MSH can enhance the activity of tyrosinase in melanocytes, change the copper compound of tyrosine into cuprous compound, strengthen the phagocytosis of melanin granules by epidermal cells, and promote the change of melanin granules from a reduced state to an oxidized state under ultraviolet irra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K8/97A61P17/00A61Q19/02
Inventor 张凯龚盛昭孙永陈佳龄胡兴国
Owner GUANGZHOU HUANYA COSMETIC SCI & TECH CO LTD
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