Methods and compositions for the diagnosis of alzheimer's disease

A technology that combines proteins and biomarkers, applied in the field of Alzheimer's disease diagnosis, can solve problems such as undiscovered clinical practicability

Active Publication Date: 2015-12-16
兰道克斯有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the clinical utility of these methods has not been found, and there is an urgent need for a method that can be used routinely to aid in the diagnosis of AD

Method used

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  • Methods and compositions for the diagnosis of alzheimer's disease
  • Methods and compositions for the diagnosis of alzheimer's disease
  • Methods and compositions for the diagnosis of alzheimer's disease

Examples

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Embodiment Construction

[0025]The present invention describes a biomarker-based approach to aid in the diagnosis of Alzheimer's disease (AD). Specifically, the relative levels or concentrations of biomarkers in fluid samples taken from patients suspected of having AD or subjects at risk of developing AD were examined. In the context of the present invention, the utility of diagnosing AD is taken as an example. However, the present invention contemplates that it may also be used to monitor the progression of AD, and to diagnose and monitor other forms of dementia and cognitive impairment, these include but are not limited to: Parkinson's dementia, Lewy body dementia, vascular dementia, minimal cognitive impairment , Frontotemporal dementia. In the context of the present invention, the term "biomarker" refers to a molecule present in a patient's biological sample, the level of which in said biological fluid may be indicative of Alzheimer's disease. Such molecules may include peptides / proteins or nucl...

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Abstract

The present invention relates to methods for the diagnosis of subjects that have or are at risk of having Alzheimer's disease (AD). In particular the present invention identifies individuals who have or are at risk of having AD through measurement of the levels of Afamin in combination with at least one other biomarker such as Alpha-1-antichymotrypsin, Alpha-2- macroglobulin, ApoB 100, Complement C5, Serine threonine protein kinase TBK1 or Complement C3 in a fluid sample taken from a subject. Furthermore, genotype (ApoIipoprotein E or glutathione S-transferase Omega) may also be taken into consideration and used within classification algorithms to determine the probability of a subject having or being at risk of having AD.

Description

Background of the invention [0001] Alzheimer's disease (AD) is a chronic neurodegenerative disorder currently identified by progressive cognitive impairment and memory loss leading to severe dementia. AD is a typical senile disease, mainly prevalent in people over 65 years old. It is the leading cause of dementia in the elderly, and as life expectancy increases, its prevalence among this population will only begin to increase. AD is not typically a life-threatening disease, but as the disease progresses to severe dementia, patients are unable to take care of themselves and often require full-time professional care. [0002] There is currently no known cure for AD, but there are treatments that can slow the progression of the disease. A method that would therefore be able to identify AD patients and possibly monitor their response to treatment would be a very useful assay (a tool for clinicians). [0003] Existing methods for AD diagnosis include psychiatric evaluation (eg, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G16B40/20
CPCG01N2333/76G01N2800/2821G16B40/00G01N33/6896G16B40/20C07K14/4711C12Q1/6883C12Q2600/112C12Q2600/158G01N2333/47G01N2333/4716G01N2333/775G01N2333/81G01N2333/8121G01N2333/912
Inventor 彼得·菲茨杰拉德伊凡·麦康内尔约翰·拉蒙特夏兰·理查德森
Owner 兰道克斯有限公司
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