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Drugs and drug delivery systems containing no gas for the treatment of pulmonary hypertension in humans

A technology for pulmonary arterial hypertension and drug delivery system, which is applied in the direction of drug combination, drug device, respiratory system diseases, etc. It can solve the problems of easy to cause danger and the inability to monitor NO concentration at the same time, and achieve accurate drug delivery, good curative effect and safe use Effect

Active Publication Date: 2018-03-09
刘平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current NO treatment devices cannot reduce NO oxidation to NO 2 , and the actual inhaled NO concentration cannot be monitored at the same time, which is likely to cause danger

Method used

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  • Drugs and drug delivery systems containing no gas for the treatment of pulmonary hypertension in humans

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Embodiment Construction

[0021] The NO-containing gas drug and drug delivery system for treating human pulmonary hypertension of the present invention will be described in detail below in conjunction with the accompanying drawings. Those skilled in the art should understand that the embodiments described below are only illustrative illustrations of the present invention, not intended for use in the present invention. impose any restrictions on it.

[0022] According to the inventive NO-containing gas medicine for treating human pulmonary hypertension, the gas medicine is composed of NO with a purity of not less than 99.99% and N with a purity of not less than 99.999% 2 The composition is mixed, and the concentration of NO is between 600ppmv and 2000ppmv. The gaseous drug is stored in a closed container at a pressure of 80 to 90 bar absolute. Within the above concentration and pressure range, the gas medicine can be safely stored and transported; at the same time, when treating patients, it is also ea...

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Abstract

The invention provides an NO gas-containing drug used for treating human pulmonary artery hypertension and a drug delivery system. The NO gas-containing drug is prepared from NO with the purity not lower than 99.9% and N2 with the purity not lower than 99.999% through mixing, the concentration of NO ranges from 600 ppmv to 2,000 ppmv, and the NO drug delivery system is used for delivering the NO gas-containing drug. The NO gas-containing drug and the drug delivery system are safe to use and accurate in drug delivery and have a good curative effect in the treatment process of human pulmonary artery hypertension.

Description

technical field [0001] The invention relates to an NO-containing gas drug and a drug delivery system for treating human pulmonary hypertension. Background technique [0002] NO (nitric oxide) has a special effect in the treatment of certain diseases such as pulmonary hypertension. However, due to the toxicity and easy oxidation of nitric oxide, it is usually necessary to mix it with nitrogen to form a low-concentration NO mixed gas drug for safe storage, transportation and use. When administering NO mixed gas medicine, it also needs to be mixed and diluted with oxygen-containing gas before it can be inhaled by patients. Therefore, the selection of an appropriate concentration of NO mixed gas medicine also has an important impact on the dilution process during patient treatment. [0003] Precise control of inhaled NO concentration is particularly important for the safety and efficacy of NO therapy. Current NO treatment devices cannot reduce NO oxidation to NO 2 , and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61M31/00A61P9/00A61P11/00
Inventor 徐绍杰刘平
Owner 刘平