Micro-array hybrid module

Abstract

The invention relates to a micro-array hybrid module, and aims to provide a micro-array hybrid auxiliary device capable of isolating hybridization reaction zones strictly in biological micro-array loading and hybridization processes and with simple operation. The main points of the technical scheme are that loading holes of a top cover and positions of reaction chambers of an isolation film correspond with each other and can be clamped tightly and connected. Chips are placed in glass slide grooves of a pedestal. The middle isolation film is attached to the biochip tightly and is clamped between the top cover and the pedestal. The pedestal aligns to positioning holes of the top cover, and the isolation film, the biochips and the pedestal are clamped tightly by utilization of positioning pins. Because the isolation film fits the chip tightly, the reaction chambers are separated strictly and completely and mutual interference and pollution are avoided. The top cover loading holes can be subjected to sealing processing by utilization of adhesive tapes, and liquid evaporation can be avoided. The whole device is convenient to use and is simple to operate, the reaction zones are independent completely, and the device can be dismounted, cleaned and used repeatedly, and is an excellent micro-array hybrid auxiliary device.

Description

technical field [0001] The invention relates to a microarray hybridization reaction auxiliary equipment, which is used in the technical fields of protein nucleic acid microarray hybridization, immunohistochemistry and the like. Background technique [0002] Biochip is a multidisciplinary comprehensive technology developed in the late 1990s. As a technology platform, biochip has been widely used in gene expression, functional genomics, disease diagnosis, drug screening and other fields. The specific application process of the biochip is to hybridize the chip with a fluorescently labeled biological sample, and determine the number of target molecules in the sample by detecting the intensity of the hybridization signal. With the development of biochip technology, related experimental detection devices have also emerged, and the biochip hybridization box is one of them. The main purpose of the hybridization box is to provide a place for hybridization between fluorescently label...

AI Technical Summary

Problems solved by technology

Some of the commonly used methods are cumbersome to operate, some consume a lot of samples, and some will cause cross-contamination. It is easy to cause the labeled sample to flow between the reaction areas during sample addition and reaction, resulting in the failure of the experiment.

In practice, the effect is not ideal, so it is necessary to provide a hybridization tool that can detect multiple samples simultaneously on a biochip and is easy to operate

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