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A kind of chlorpyrifos composite microsphere

A technology of composite microspheres and chlorpyrifos, which is applied in fertilizer mixtures, biocides, plant growth regulators, etc., can solve the problems of low loading of organic drugs, low drug loading of hydrophobic drugs, and poor mechanical properties of microspheres. , to achieve the effect of improving drug loading performance, good ion exchange performance, complexation and chelation performance, and high skeleton density

Active Publication Date: 2018-03-06
ZHONGKAI UNIV OF AGRI & ENG
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AI Technical Summary

Problems solved by technology

However, sodium alginate has strong hydrophilicity, large gel pore size, low drug loading capacity for hydrophobic drugs, fast drug release, and is prone to burst release.
In addition, the mechanical properties of sodium alginate gel microspheres are poor, and the surface of the microspheres is easy to sag inward during the manufacturing or drying process, and it is easy to degrade and swell when encountering water, resulting in a decrease in drug loading performance, and sodium alginate gel contains a large amount of Hydrophilic group, the loading capacity of organic drugs is not high

Method used

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  • A kind of chlorpyrifos composite microsphere
  • A kind of chlorpyrifos composite microsphere
  • A kind of chlorpyrifos composite microsphere

Examples

Experimental program
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Effect test

Embodiment 1-12

[0044] Example 1-12 Preparation of humic acid / sodium alginate / chlorpyrifos composite microspheres

[0045] According to the mass ratio of humic acid to sodium alginate, the mass of sodium alginate was fixed, and different masses of humic acid were dissolved in 20 mL of 0.1 mol / L NaOH aqueous solution, and heated under magnetic stirring to fully dissolve; accurately weigh 0.6 g of chlorpyrifos Dissolve in 5 mL of absolute ethanol, and fully mix with humic acid solution; accurately weigh 0.3g of sodium alginate, slowly add to humic acid / chlorpyrifos blend, stop heating, stop stirring after fully dissolved, and ultrasonically disperse to remove bubbles to obtain humic acid / sodium alginate / chlorpyrifos blend sol. The dropping height of the fixed syringe pump is 30 cm, and the dropping rate is 50 mLh -1 , the size of the medical syringe is 10 mL, drop the blended sol into a volume of 50 mL of CaCl 2 The solution was cross-linked into balls, washed three times and then vacuum-drie...

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Abstract

The invention discloses chlorpyrifos composite microspheres. The composite microspheres are prepared through loading chlorpyrifos by using humic acid modified sodium alginate as a composite substrate material and taking calcium chloride (CaCl2) as a cross-linking agent. According to the composite microspheres, a novel composite substrate material is formed through mixing humic acid and sodium alginate. The structure of each microsphere is improved by using interaction between humic acid and sodium alginate, so that the network structure of each composite microsphere becomes dense, the skeletal density of each microsphere is increased, the amount of pesticides capable of being loaded is increased, the capability of pesticide embedding is enhanced, and thus the pesticide loading property of the microspheres is enhanced; and the composite microspheres not only can improve the stability of chlorpyrifos, but also increase the pesticide loading amount and entrapment rate of chlorpyrifos, thereby having excellent pesticide loading property. Humic acid can also serve as a nutritional ingredient for plants, so that the composite microspheres have a pesticide and fertilizer integrated function.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and more specifically relates to a chlorpyrifos composite microsphere. Background technique [0002] Chlorpyrifos is currently the most sold insecticide in the world. As a widely used insecticide, it has the advantages of high efficiency, excellent control effect and broad market prospects. But it has the disadvantages of high toxicity and strong odor. [0003] The microspheres are made of natural or synthetic polymer materials, and the drugs wrapped inside are solid or liquid to form drug-loaded gel microspheres. In the field of biological pesticides, because many pesticides cannot be used directly, or the effect of direct use is not good, if the effect of pesticides is to be the best, it is necessary to enhance the system through other means, one of which is to use high Molecular materials are used to embed drugs to prepare drug-loaded microspheres. This polymer material minimize...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/28A01N57/16C05G3/02A01P7/04C05G3/60
Inventor 周新华林粤顺周红军龚圣徐华
Owner ZHONGKAI UNIV OF AGRI & ENG
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