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Application of nonratt021972 small interfering RNA in the preparation of drugs for diabetes and complicated diseases

A technology of NONRATT021972 and diabetes drugs, which is applied in the field of diabetes drug use inventions, and can solve the problems of insufficient research on long non-coding RNAs

Active Publication Date: 2019-01-11
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Application of nonratt021972 small interfering RNA in the preparation of drugs for diabetes and complicated diseases
  • Application of nonratt021972 small interfering RNA in the preparation of drugs for diabetes and complicated diseases
  • Application of nonratt021972 small interfering RNA in the preparation of drugs for diabetes and complicated diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The oral or injectable long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation suitable for the treatment of diabetes mellitus, hypoglycemia and concurrent diseases is prepared by methods known in the art.

Embodiment 2

[0024] The oral or injectable long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation suitable for the treatment of related diseases related to the prevention and treatment of hyperlipidemia is prepared by the method known in the technical field.

Embodiment 3

[0026] The long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation suitable for oral or injection treatment related to glucokinase (GK)-mediated diseases is prepared by methods known in the art.

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Abstract

The invention discloses a use of NONRATT021972 small interfering RNA in preparation of a drug for treating diabetes mellitus and diabetic complication. The NONRATT021972 small interfering RNA can reduce diabetes mellitus type 2 model rat blood sugar and a serum inflammatory factor level, improve antioxidant substance activity, improve a blood insulin level, improves a hepatic glycogen level and improves glucokinase (GK) activity. The NONRATT021972 small interfering RNA can be used in preparation of drugs for reducing blood sugar and preventing and treating high blood fat-caused related diseases, GK dysfunction-caused diabetes mellitus, metabolic diseases and related complication, and hepatic tissue long non-coding ribonucleic acid NONRATT021972 small interfering RNA dysfunction-related diseases. The NONRATT021972 small interfering RNA in forms of an oral medicine, an injection, a lozenge or other local or whole body agents can diagnose, prevent and treat related diseases.

Description

technical field [0001] The invention belongs to the technical field of diabetes medicine application invention. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic clinical syndromes. With the development of society and the improvement of people's living standards, the prevalence of diabetes is increasing year by year. In developed countries, the prevalence of diabetes has reached 3%-7%. , has become the fourth priority disease after cancer, AIDS, and cardiovascular and cerebrovascular diseases, and has become the fifth leading cause of death in the world. Diabetes is divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes, whether it is type 1 (insulin-dependent) or type 2 (non-insulin-dependent) diabetes, the main symptom of which is hyperglycemia . Hyperglycemia is the leading cause of diabetes complications, and it is estimated that one in six people worldwide is at risk of developing diabetes complications. Type 2 ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61K31/713A61P3/10A61P3/06A61P1/16
Inventor 梁尚栋宋渺渺彭力超吴炳李桂林刘双梅徐宏吴红张春平
Owner NANCHANG UNIV
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