Compositions and methods for treating microbiota-associated psychiatric conditions and diseases

Abstract

In alternative embodiments, the present invention provides compositions and methods for the treatment, amelioration and prevention of various disorders and conditions in mammals, including genetically predisposed disorders and chronic disorders in which intestinal Microorganisms or bacterial flora in at least one etiological or symptom-producing factor, for example, where microorganisms or bacterial flora in the intestine produce neurotoxins or neurotoxic agents that enter through the gastrointestinal (GI) tract (e.g., the colon) body, and to systemic spaces, such as through neural streams or via circulation to the central nervous system (CNS), peripheral nervous system (PNS), and other nervous systems including the brain. In alternative embodiments, the methods and compositions of the invention comprise or involve the use of medicaments, formulations and medicaments comprising rifaximin or equivalent active agents which inhibit or Eradication of microbiota superinfections causing various psychiatric disorders. These compositions have been found to be effective in a wide range of disorders, particularly in the obsessive-compulsive disorder group (OCD).

Description

technical field

[0001] The invention generally relates to medicine, gastroenterology, pharmacology, and microbiology. In alternative embodiments, the present invention provides compositions and methods for treating, ameliorating, and preventing various disorders and conditions in mammals, including genetically predisposed disorders and chronic disorders, wherein intestinal The microorganisms or bacterial flora in the gut are at least one causative or symptom-producing factor, for example where the microorganisms or bacterial flora in the gut produce neurotoxins or neurotoxic agents, which enter the body through the gastrointestinal (GI) tract (e.g., the colon) and Access to systemic spaces, eg, via neural streams or via circulation to the central nervous system (CNS), peripheral nervous system (PNS), and other nervous systems including the brain. In alternative embodiments, the methods and compositions of the invention include or include the use of medicaments, formulations a...