Novel composite quaternary phosphonium salt and its preparation method and antibacterial application
A quaternary phosphonium salt and a new technology, applied in the field of fine chemical synthesis, can solve the problems of short duration of inhibitory action, unsatisfactory effect, poor stability, etc., and achieve the effects of low synthesis price, low raw material consumption and good stability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0027] A compound quaternary phosphonium salt A in a single crystal form has the molecular structure shown in the above general formula, wherein R is Cl.
[0028] Its preparation method is as follows:
[0029] (1) Dissolve 2 mmol of 2-chlorobenzyl bromide and 1.6 mmol of triphenylphosphine in 20 mL of acetone, stir and reflux at 65-70 ºC for 24 hours, during which a white precipitate is formed, and after natural cooling, suction filter, and separate Wash the filter cake with a small amount of acetone and ether to remove impurities and accelerate drying, and then vacuum-dry to obtain 2-chlorobenzyltriphenylphosphine bromide with a yield of 79.3%; infrared spectroscopic analysis: IR (cm -1 ): ν(benzene ring C–H): 3053; ν(CH 2 ): 2925, 2884; ν(C=C): 1587, 1432; ν(C–P): 1111;
[0030] (2) 1 mmol of the obtained 2-chlorobenzyltriphenylphosphine bromide and CuCl 2 2H 2 O 0.45 mmol was dissolved in methanol 15mL, then added 0.5mL hydrochloric acid, continued to stir, while heatin...
Embodiment 2
[0038] A compound quaternary phosphonium salt B in a single crystal form has the molecular structure shown in the above general formula, wherein R is Br.
[0039] Its preparation method is as follows:
[0040] (1) Dissolve 2 mmol of 2-bromobenzyl bromide and 2 mmol of triphenylphosphine in 30 mL of acetone, stir and reflux at 65-70 ºC for 20 hours, during which a white precipitate is formed, and after natural cooling, suction filter, and separate Wash the filter cake with a small amount of acetone and ether to remove impurities and accelerate drying, and then vacuum-dry to obtain 2-bromobenzyltriphenylphosphine bromide with a yield of 86.4%; infrared spectroscopic analysis: IR (cm -1 ): ν(benzene ring C–H): 3053; ν(CH 3 ): 2922, 2884; ν(C=C): 1584, 1432; ν(C–P): 1114;
[0041] (2) 1 mmol of the obtained 2-bromobenzyltriphenylphosphine bromide and CuCl 2 2H 2 O 0.5 mmol was dissolved in 20 mL of methanol, then 1 mL of hydrochloric acid was added, stirring continuously, whil...
Embodiment 3
[0043] A compound quaternary phosphonium salt C in a single crystal form has the molecular structure shown in the above general formula, wherein R is NO 2 .
[0044] Its preparation method is as follows:
[0045](1) Dissolve 2 mmol of 2-nitrobenzyl bromide and 2.4 mmol of triphenylphosphine in 40 mL of acetone, stir and reflux at 65-70 ºC for 16 hours, during which a white precipitate is formed, and after natural cooling, suction filter, and separate Wash the filter cake with a small amount of acetone and ether to remove impurities and accelerate drying, and then vacuum-dry to obtain 2-nitrobenzyltriphenylphosphine bromide with a yield of 88.6%; infrared spectroscopic analysis: IR (cm -1 ):ν(NH 2 ): 3341; ν(benzene ring C–H): 3050; ν(CH 2 ): 2922, 2875; ν(C=C): 1581, 1432; ν(NO 2 ): 1530, 1335; ν(C–P): 1105.
[0046] (2) 1 mmol of the obtained 2-nitrobenzyltriphenylphosphine bromide and CuCl 2 2H 2 Dissolve O 0.56 mmol in 25 mL of methanol, add 1.5 mL of hydrochloric ac...
PUM
Property | Measurement | Unit |
---|---|---|
diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com