A kind of cmc nanofibrous film loaded with silver nanoparticles and preparation method thereof

A nanofiber film and silver nanoparticle technology, which is applied in fiber treatment, plant fiber, non-woven fabrics, etc., can solve the problem of poor biocompatibility of silver-loaded nanoparticle/composite fiber film, limited application of antibacterial fiber film, fiber film Structural damage and other problems, to achieve the effect of excellent antibacterial properties, excellent biocompatibility and degradability, high swelling rate

Active Publication Date: 2018-05-01
BEIJING INSTITUTE OF TECHNOLOGYGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the characteristics of anionic polymers in the prior art, it is difficult to obtain nanofiber membranes by electrospinning. The silver-loaded nanoparticles / composite fiber membranes prepared by the prior art have poor biocompatibility and by-products are produced during the preparation process. And the structure of the fiber membrane is destroyed, which leads to the limitation of the application of the antibacterial fiber membrane in the field of biomedicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1, prepare the mixed solution of PEO and CMC.

[0029] Add 0.65g of PEO and 0.65g of CMC successively to 23.7g of water and stir until completely dissolved, then let it stand for defoaming to prepare a spinning dope with a mass concentration of 5.2%.

[0030] Step 2, preparing PEO / CMC composite nanofibers by electrospinning.

[0031] The applied voltage is 22kV, the receiving distance is 10cm, the advancing speed is 2ml / h, the air humidity is 10%, the temperature is room temperature, and the needle used for spinning is No. 9 (inner diameter 0.6mm, inner diameter 0.9mm). Air dry thoroughly.

[0032] Step 3, ion exchange and ultraviolet light reduction to prepare silver-loaded nanofibers.

[0033] Soak the nanofibers obtained in step 2 in a 0.1 mol / L silver nitrate solution for 2 hours, then take them out and rinse them with deionized water to remove excess silver ions on the surface, and dry them in the dark. Place it in a dark box with a humidity of 70% and a te...

Embodiment 2

[0036] Step 1, prepare the mixed solution of PEO and CMC.

[0037] Add 1g of PEO and 1g of CMC successively to 23g of water and stir until completely dissolved, then let it stand for defoaming to prepare a spinning stock solution with a mass concentration of 8%.

[0038] Step 2, preparing PEO / CMC composite nanofibers by electrospinning.

[0039] The applied voltage is 22kV, the receiving distance is 10cm, the advancing speed is 2mL / h, the air humidity is 10%, the temperature is room temperature, the needle used for spinning is No. 9 (inner diameter 0.6mm, inner diameter 0.9mm), after receiving the fiber with aluminum foil, the Air dry thoroughly.

[0040] Step 3, ion exchange and ultraviolet light reduction to prepare silver-loaded nanofibers.

[0041] Soak the nanofibers obtained in step 2 in a 0.1 mol / L silver nitrate solution for 2 hours, then take them out and rinse them with deionized water to remove excess silver ions on the surface, and dry them in the dark. Put it i...

Embodiment 3

[0044] Step 1, prepare the mixed solution of PEO and CMC.

[0045] Add 1.5g of PEO and 1.5g of CMC successively to 22g of water and stir until completely dissolved, then let it stand for defoaming to prepare a spinning dope with a mass concentration of 11.6%.

[0046] Step 2, preparing PEO / CMC composite nanofibers by electrospinning.

[0047] The applied voltage is 22kV, the receiving distance is 10cm, the propulsion speed is 2mL / h, the air humidity is 10%, the temperature is room temperature, the needle used for spinning is No. Dry thoroughly.

[0048] Step 3, ion exchange and ultraviolet reduction to prepare silver-loaded nanofibers.

[0049]Soak the nanofibers obtained in step 2 in a 0.1 mol / L silver nitrate solution for 2 hours, then take them out and rinse them with deionized water to remove excess silver ions on the surface, and dry them in the dark. Put it in a dark box with a humidity of 70% and a temperature of 30° C., and irradiate it with ultraviolet light with a...

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Abstract

The invention discloses a carboxymethyl cellulose (CMC) nanofiber membrane loaded with silver nanoparticles and a preparation method thereof. The purpose is to provide a simple and pollution-free preparation method, and the prepared fiber membrane has excellent antibacterial properties and Biocompatible silver-loaded antibacterial nanofiber with only CMC as substrate and preparation method thereof. In the present invention, the mixed solution of polyethylene oxide (PEO) and CMC is used as the spinning stock solution to carry out electrospinning, and then the fiber film is soaked in a silver nitrate solution of a certain concentration, taken out and dried in the dark and placed in the The reduction is carried out in humid air at room temperature, and finally a nanofiber membrane of CMC nanofibers loaded with silver nanoparticles is prepared. The fiber membrane prepared by the invention has excellent antibacterial properties and biocompatibility, and the structure and mechanical properties of the fiber membrane itself are well maintained, and is a preferred material in the field of wound dressing, and the preparation method is simple, economical and environment-friendly.

Description

technical field [0001] The invention relates to a preparation method of a nanofiber membrane, in particular to a CMC nanofiber membrane loaded with silver nanoparticles and a preparation method thereof. Background technique [0002] Nanofibrous membrane has the advantages of large surface area, high porosity, loose structure, pre-designed composition according to the required function, simulating extracellular matrix, and simple preparation method, and has great application potential in many fields. It has been used in food, medicine, Daily chemicals and other fields have been widely used. In particular, nanofibrous membranes prepared with natural polymers as spinning solutions not only have the above characteristics, but also have excellent biocompatibility, biodegradability and renewability. Electrospinning is the simplest and most efficient method for preparing nanofibrous membranes. [0003] The combination of silver nanoparticles (AgNPs) with antibacterial properties ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4258D04H1/728D01D5/00D06M11/83D06M101/06
Inventor 王飞俊师丹丹邵自强兰天张云华王文俊
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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