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Compound yinlingtong capsule quality detection method

A quality inspection method and compound Yinlingtong technology, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult and effective separation of substances with similar structures, difficult to be accurate, and many interference factors.

Inactive Publication Date: 2016-03-02
NANJING ZHONGKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The inventor analyzes the existing quality standards and finds that there are the following problems: 1) the method is single and difficult to be accurate; 2) the content determination method adopts the thin-layer scanning method, which has poor reproducibility and is greatly affected by the spotting environment. When the thin layer is unfolded, it is affected by the external temperature and humidity, and there are many interference factors; and it is difficult to effectively separate substances with similar structures, and the inspection cycle is longer. The present invention further improves the quality control of Compound Yinlingtong Capsules

Method used

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  • Compound yinlingtong capsule quality detection method
  • Compound yinlingtong capsule quality detection method
  • Compound yinlingtong capsule quality detection method

Examples

Experimental program
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Effect test

Embodiment 1

[0171] formula:

[0172] Ginkgo biloba leaves 333g, Ganoderma lucidum 333g, Scrophulariaceae 278g, Achyranthes bidentata 278g, Gastrodia elata 125g, Shichangpu 167g.

[0173] Preparation:

[0174] (1) Pulverization: Pulverize Shichangpu into granules and set aside.

[0175] (2) CO 2 Supercritical extraction: Take Shichangpu particles in the extraction kettle, CO 2 Supercritical extraction, wherein the extraction pressure is 30Mpa, the temperature of the extraction kettle is 60°C, and the extraction time is 1.5 hours, to obtain the volatile oil and the raffinate of Acorus calamus.

[0176](3) Inclusion of volatile oil: Take volatile oil and dissolve it with ethanol of equal volume to obtain volatile oil ethanol solution; take β-cyclodextrin in an amount 4 times the weight of volatile oil, grind it with water 4 times the amount of β-cyclodextrin, pour Put it into the colloid mill, slowly and continuously add the above-mentioned volatile oil ethanol solution dropwise, grind a...

Embodiment 2

[0183] The method for assaying the content of the compound Yinlingtong capsule prepared according to the method of Example 1:

[0184] a) Preparation of the test solution Take the content of this product, grind it finely, accurately weigh 3g, put it in a 30ml glass centrifuge tube, add 30ml of petroleum ether (boiling point is 60-90°C), ultrasonic (350W, 50kHz) Treat for 30 minutes, centrifuge for 5 minutes (under the condition of 2000 rpm), discard the petroleum ether solution, add petroleum ether (boiling point is 60-90°C) 30ml ultrasonic (350W, 50kHz condition) for 30 minutes, and centrifuge for 5 minutes ( 2000 r / min), discard the petroleum ether liquid. Add 30ml of methanol to the centrifuge tube, ultrasonic (350W, 50kHz) for 30 minutes, centrifuge for 5 minutes (2000 rpm), collect the methanol liquid; then add 30ml of methanol to the centrifuge tube, ultrasonic (350W, 50kHz ) for 30 minutes, centrifuged for 5 minutes (under the condition of 2000 rpm), collected the meth...

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Abstract

The present invention discloses a compound yinlingtong capsule quality detection method, which provides thin-layer identification on ganoderma lucidum, radix scrophulariae and acorus tatarinowii, wherein a high-performance liquid chromatography method is used to carry out content determination on ginkgolide A, ginkgolide B, ginkgolide C and bilobalide. According to the present invention, when the quality control method is used to carry out separation detection, advantages of interference factor resisting, high detection efficiency, good stability, rapid analysis and short detection period can be provided; and the method is the reliable compound yinlingtong capsule control method, and establishes the accurate and feasible control standard for the compound yinlingtong capsule quality detection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a quality detection method of compound Yinlingtong capsules. Background technique [0002] Compound Yinlingtong Capsules contain six medicinal components of Ganoderma lucidum, Ginkgo biloba, Achyranthes bidentata, Scrophulariae scrophulariae, Shichangpu and Tianma. Eliminate brain symptoms such as forgetfulness, headache, dizziness, etc., prevent and vigorously relieve stroke, senile dementia and other brain diseases. It is a brain protection and brain health product for brain users and people who often drink alcohol. [0003] The inventor analyzes the existing quality standards and finds that there are the following problems: 1) the method is single and difficult to be accurate; 2) the content determination method adopts the thin-layer scanning method, which has poor reproducibility and is greatly affected by the spotting environment. When the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90
Inventor 冯鹏冯敏沈建钱一帆陈素玲朱韵韵
Owner NANJING ZHONGKE PHARMA
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