Reversible microfluidic chip fixture

Abstract

The invention discloses a reversible clamp for a micro-fluidic chip. The reversible clamp comprises an upper cover plate and a base which are fixed vertically, a clamping space is formed between the upper cover plate and the base, and the micro-fluidic chip and a liquid path converting board are arranged in the clamping space in a stacked mode; the micro-fluidic chip comprises an upper chip body and a lower chip body which are arranged in a stacked mode, a chip gasket is arranged between the contact faces of the upper chip body and the lower chip body, microchannels are formed in the contact faces of the upper chip body and / or the lower chip body in an concave mode, and a sample inlet and a sample outlet which are communicated with the two ends of the corresponding microchannel are formed in the upper chip body; an L-shaped liquid inlet channel is formed in one end of the liquid path converting board, one end of the liquid inlet channel is communicated with the sample inlet, the other end of the liquid inlet channel is communicated with a sample introduction clamp body, an L-shaped liquid outlet channel is formed in the other end of the liquid path converting board, one end of the liquid outlet channel is communicated with the sample outlet, and the other end of the liquid outlet channel is communicated with a sample discharge clamp body. The hard micro-fluidic chip is sealed reversibly through pressure and the gasket, and a traditional hard chip sealing process is avoided.

Description

technical field [0001] The application belongs to the technical field of microfluidic chips, and in particular relates to a multi-inlet and reversible microfluidic chip fixture, which is suitable for observing biochemical experiments on the microfluidic chip with a metallographic microscope. Background technique [0002] Microfluidics integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. Due to its small size, low reagent consumption and high integration, more and more researchers have begun to pay attention to microfluidic chips. [0003] For the use of microfluidic chips, an...

AI Technical Summary

Problems solved by technology

This type of connection method is an irreversible connection, the chip and the fluid conduit cannot be disassembled and used later, and the economic cost is relatively high. This connection method also greatly affects the fixing and observation of the chip

In addition, the glue method is complicated to operate. On the one hand, the glue is very fluid and may spread to the observation area, affecting the experimental observation; on the other hand, it may cause contamination to the sample, thus hindering the large-scale application of microfluidic chips.

[0006] Reversible connection fixtures adapted to rigid microfluidic chips can solve these problems well, but traditional chip fixtures have technical problems such as complicated connection methods, fixed connection methods, and lack of adjustability

At the same time, the connection between the fixture and the chip is poorly sealed, and it is prone to pressure loss and liquid leakage, which affects the use effect of the chip

Images