Reversible microfluidic chip fixture

Abstract

The application discloses a reversible microfluidic chip fixture, which includes an upper cover plate and a base fixed up and down, a clamping space is formed between the upper cover plate and the base, and a microfluidic chip and a liquid circuit are superimposed in the clamping space The conversion plate, the microfluidic chip includes a stacked upper chip and a lower chip, a chip gasket is provided between the contact surface of the upper chip and the lower chip, and a microchannel is formed on the contact surface of the upper chip and / or the lower chip, The upper chip is formed with a sample inlet and a sample outlet connected to both ends of the microchannel, and an L-shaped liquid inlet channel is formed at one end of the liquid channel conversion plate. One end of the liquid inlet channel is connected to the sample inlet, and the other end is connected to the sample The clamps are connected, and an L-shaped liquid outlet channel is formed at the other end of the liquid channel conversion plate. One end of the liquid outlet channel is connected with the sample outlet, and the other end is connected with the sample outlet fixture. The jig of the present invention reversibly seals the hard microfluidic chip through the pressure and the gasket, avoiding the traditional hard chip sealing process.

Description

technical field [0001] The application belongs to the technical field of microfluidic chips, and in particular relates to a multi-inlet and reversible microfluidic chip fixture, which is suitable for observing biochemical experiments on the microfluidic chip with a metallographic microscope. Background technique [0002] Microfluidics integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. Due to its small size, low reagent consumption and high integration, more and more researchers have begun to pay attention to microfluidic chips. [0003] For the use of microfluidic chips, an...

AI Technical Summary

Problems solved by technology

This type of connection method is an irreversible connection, the chip and the fluid conduit cannot be disassembled and used later, and the economic cost is relatively high. This connection method also greatly affects the fixing and observation of the chip

In addition, the glue method is complicated to operate. On the one hand, the glue is very fluid and may spread to the observation area, affecting the experimental observation; on the other hand, it may cause contamination to the sample, thus hindering the large-scale application of microfluidic chips.

[0006] Reversible connection fixtures adapted to rigid microfluidic chips can solve these problems well, but traditional chip fixtures have technical problems such as complicated connection methods, fixed connection methods, and lack of adjustability

At the same time, the connection between the fixture and the chip is poorly sealed, and it is prone to pressure loss and liquid leakage, which affects the use effect of the chip

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