Compound mulberry extract product pellets and preparation method thereof

A technology of mulberry extract and pellets, which is applied in the field of medicine and food, to achieve the effects of rapid onset of action, large dispersion area and high bioavailability

Inactive Publication Date: 2016-04-13
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]Mulberry extract and apple polyphenols have many unilateral health products, but there is no report about the compound preparation of the two. At present, about mulberry extract and apple polyphenols Polyphenol products are well recognized by consumers. Except for unilateral preparations, these products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, Some irritation to gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take the following ingredients for the recipe

[0030] Mulberry extract 10g (calculated as pure product)

[0031] Apple polyphenols 5g

[0032] Crystal cellulose 80g

[0033] Hydroxypropyl Methyl Cellulose 5g

[0034] Prepare pellet formulations as follows:

[0035] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula and add them to the crystal cellulose, grind them to a micronized level with a ball mill, and mix well;

[0036] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0037] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0039] Take the following ingredients for the recipe

[0040] Mulberry extract 20g (calculated as pure product)

[0041] Apple polyphenols 8g

[0042] Crystal cellulose 65g

[0043] Hypromellose 7g

[0044] Prepare pellet formulations as follows:

[0045] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula, add them to starch, grind them to a micronized level with a ball mill, and mix well;

[0046] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0047] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0049] Take the following ingredients for the recipe

[0050] Mulberry extract 30g (calculated as pure product)

[0051] Apple polyphenols 10g

[0052] Sucrose 45g

[0053] Starch 10g

[0054] Polyvinylpyrrolidone 5g

[0055] Prepare pellet formulations as follows:

[0056] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;

[0057] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0058] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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Abstract

The invention provides compound mulberry extract product pellets, which can be prepared by an mulberry extract product, apple polyphenol and a pharmaceutic adjuvant. The compound mulberry extract product pellets are characterized in that the pharmaceutic adjuvant is an excipient and an adhesive, the weight percentage of the mulberry extract product in the compound mulberry extract product pellets accounts for 10-30%, the weight percentage of the apple polyphenol in the compound mulberry extract product pellets accounts for 5-10%, the weight percentage of the excipient accounts for 50-80%, and the weight percentage of the adhesive accounts for 5-10%. The compound mulberry extract product pellets have the advantages that leaching rate is high, bioavailability is high, preparation method is simple and convenient, and operation is easy.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made from a compound mulberry extract and a preparation method thereof. Background technique: [0002] There are many unilateral health products of mulberry extract and apple polyphenols, but there is no report on the compound preparation of the two. At present, products related to mulberry extract and apple polyphenols are well received by consumers. Except for unilateral preparations, they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which has certain irritation to gastric mucosa; low bioavailability, etc. . Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable releas...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A23L1/29A61K36/73A61K9/16A61K47/38A61K47/36
Inventor魏洪君
OwnerJF PHARMALAND TECH DEV