Compound mulberry extract product pellets and preparation method thereof
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A technology of mulberry extract and pellets, which is applied in the field of medicine and food, to achieve the effects of rapid onset of action, large dispersion area and high bioavailability
Inactive Publication Date: 2016-04-13
JF PHARMALAND TECH DEV
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Problems solved by technology
[0002]Mulberry extract and apple polyphenols have many unilateral health products, but there is no report about the compound preparation of the two. At present, about mulberry extract and apple polyphenols Polyphenol products are well recognized by consumers. Except for unilateral preparations, these products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, Some irritation to gastric mucosa; low bioavailability and other disadvantages
Method used
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Embodiment 1
[0029] Take the following ingredients for the recipe
[0030] Mulberry extract 10g (calculated as pure product)
[0035] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula and add them to the crystalcellulose, grind them to a micronized level with a ball mill, and mix well;
[0036] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;
[0037] (3) Micro-pills are made by extrusion-spheronization into pellets.
Embodiment 2
[0039] Take the following ingredients for the recipe
[0040] Mulberry extract 20g (calculated as pure product)
[0045] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula, add them to starch, grind them to a micronized level with a ball mill, and mix well;
[0056] (1) Take the mulberry extract and apple polyphenols in the amount of the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;
[0058] (3) The centrifugal-fluidized pelletizing method is used to make pellets.
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Abstract
The invention provides compound mulberry extract product pellets, which can be prepared by an mulberry extract product, apple polyphenol and a pharmaceutic adjuvant. The compound mulberry extract product pellets are characterized in that the pharmaceutic adjuvant is an excipient and an adhesive, the weight percentage of the mulberry extract product in the compound mulberry extract product pellets accounts for 10-30%, the weight percentage of the apple polyphenol in the compound mulberry extract product pellets accounts for 5-10%, the weight percentage of the excipient accounts for 50-80%, and the weight percentage of the adhesive accounts for 5-10%. The compound mulberry extract product pellets have the advantages that leaching rate is high, bioavailability is high, preparation method is simple and convenient, and operation is easy.
Description
Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made from a compound mulberry extract and a preparation method thereof. Background technique: [0002] There are many unilateral health products of mulberry extract and apple polyphenols, but there is no report on the compound preparation of the two. At present, products related to mulberry extract and apple polyphenols are well received by consumers. Except for unilateral preparations, they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which has certain irritation to gastric mucosa; low bioavailability, etc. . Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable releas...
Claims
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Application Information
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