Hericium erinaceus micro-pills and preparation method thereof

A technology of Hericium erinaceus pellets and Hericium erinaceus, applied in the field of medicine and food, to achieve high bioavailability and rapid onset of effect

Inactive Publication Date: 2016-04-27
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, Hericium erinaceus products are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above dosage forms is long Disintegrate at a certain point in the body, which has certain irritation to the gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take the following ingredients for the recipe

[0029] Hericium Hericium Extract 10g

[0030] Microcrystalline cellulose 85g

[0031] Hydroxypropyl Methyl Cellulose 5g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take Hericium erinaceus in the amount of the above formula, add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] Hericium Hericium Extract 20g

[0039] Starch 75g

[0040] Polyvinylpyrrolidone 5g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take Hericium erinaceus in the amount of the above formula, add starch, pulverize to micronized level with a ball mill, and mix well;

[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0044] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Hericium Hericium Extract 25g

[0048] Sucrose 45g

[0049] Starch 25g

[0050] Polyvinylpyrrolidone 5g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take Hericium erinaceus in the amount of the above formula, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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Abstract

The present invention provides hericium erinaceus micro-pill preparation, which is prepared from hericium erinaceus and pharmaceutical auxiliary materials, and is characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, the hericium erinaceus content in the hericium erinaceus micro-pill preparation is 5-30 wt%, the excipient content in the hericium erinaceus micro-pill preparation is 65-85%, and the binder content in the hericium erinaceus micro-pill preparation is 1-5%. The hericium erinaceus micro-pill preparation of the present invention has characteristics of high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to Hericium erinaceus pellets and a preparation method thereof. Background technique: [0002] At present, products related to Hericium erinaceus are well received by consumers, and they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; disintegration at a certain point in the body has harmful effects on the gastric mucosa. Certain irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plast...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/06A61K9/16A23L1/30
Inventor魏洪君
OwnerJF PHARMALAND TECH DEV