Oral liquid for congenital adrenal cortical hyperplasia

An adrenal cortex and hyperplasia technology, applied in the field of oral liquid, can solve the problems of adverse effects of treatment effects, iatrogenic Cushing's syndrome, simple masculinization, etc., and achieves good hypokalemia, scientific and rigorous prescription, and good prevention. effect of action

Inactive Publication Date: 2016-06-15
QILU CHILDRENS HOSPITAL OF SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Pure masculinity
[0010] 3. Non-classic
However, long-term and excessive administration of fludrocortisone can lead to side effects such as edema, high blood pressure, hypokalemia, and e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 preparation is used for the oral liquid of adjuvant treatment congenital adrenal hyperplasia

[0033] The formula is: Rehmannia glutinosa 25 grams, Daqingye 30 grams, Poria cocos 25 grams, capillary wormwood 20 grams, cornus 20 grams, wild chrysanthemum 30 grams, asarum 18 grams, Atractylodes macrocephala 10 grams, Fangji 15 grams, chuanxiong 25 grams , 25 grams of wax gourd skin, 20 grams of yam, 15 grams of Moutan skin, 10 grams of Alisma, and 20 grams of Prunella vulgaris.

[0034] The preparation method is as follows: take each raw material medicine, mix, add 10 times the amount (weight multiple) of water, soak for 30 minutes, decoct for 1.5 hours, filter to obtain the filtrate and filter residue, add 8 times the amount (weight multiple) of water to the filter residue, decoct Boil for 30 minutes, filter to obtain the filtrate; combine the two filtrates, concentrate to a relative density of 1.08 (measured at 50°C), and obtain the product.

[0035]The me...

Embodiment 2

[0038] Embodiment 2 preparation is used for the oral liquid of adjuvant treatment congenital adrenal hyperplasia

[0039] The formula is: 20 grams of Rehmannia glutinosa, 25 grams of Daqingye, 30 grams of Poria cocos, 25 grams of capillary, 15 grams of cornus, 25 grams of wild chrysanthemum, 20 grams of Asarum, 15 grams of Atractylodes macrocephala, 10 grams of Fangji, 20 grams of Chuanxiong , 30 grams of winter melon skin, 25 grams of yam, 10 grams of peony skin, 5 grams of Alisma, and 25 grams of Prunella vulgaris.

[0040] The preparation method is as follows: take each raw material, mix, add 10 times the amount (weight multiple) of water, soak for 30 minutes, decoct for 1.0 hour, filter to obtain the filtrate and filter residue, add 8 times the amount (weight multiple) of water to the filter residue, decoct Boil for 40 minutes, filter to obtain the filtrate; combine the two filtrates, concentrate to a relative density of 1.05 (measured at 50°C), and obtain the obtained pro...

Embodiment 3

[0041] Embodiment 3 preparation is used for the oral liquid of adjuvant treatment congenital adrenal hyperplasia

[0042] The formula is: 30 grams of Rehmannia glutinosa, 35 grams of Daqingye, 20 grams of Poria, 15 grams of capillary, 25 grams of cornus, 35 grams of wild chrysanthemum, 15 grams of Asarum, 5 grams of Atractylodes macrocephala, 20 grams of Fangji, 30 grams of Chuanxiong , 20 grams of winter melon skin, 15 grams of yam, 20 grams of Moutan skin, 15 grams of Alisma, and 15 grams of Prunella vulgaris.

[0043] The preparation method is as follows: take each raw material medicine, mix, add 10 times the amount (weight multiple) of water, soak for 30 minutes, decoct for 1.5 hours, filter to obtain the filtrate and filter residue, add 8 times the amount (weight multiple) of water to the filter residue, decoct Boil for 30 minutes, filter to obtain the filtrate; combine the two filtrates, concentrate to a relative density of 1.09 (measured at 50°C), and obtain the product...

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PUM

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Abstract

The invention discloses oral liquid for congenital adrenal cortical hyperplasia. The oral liquid is prepared from 20-30 g of radix rehmanniae praeparata, 25-35 g of folium isatidis, 20-30 g of poria cocos, 15-25 g of herba artemisiae scopariae, 15-25 g of pulp of dogwood fruit, 25-35 g of flos chrysanthemi indici, 15-20 g of asarum, 5-15 g of rhizoma atractylodis macrocephalae, 10-20 g of radix stephaniae tetrandrae, 20-30 g of ligusticum wallichii, 20-30 g of Chinese waxgourd peel, 15-25 g of rhizoma dioscoreae, 10-20 g of moutan bark, 5-15 g of rhizoma alismatis and 15-25 g of spica prunellae. The oral liquid is an oral preparation which is taken in the morning and at night, children under five take10 ml each day, and children aging from 6-12 take 20 ml each day. The formula is scientific and rigorous, targeting property is high, and the oral liquid can well prevent and treat edema, hypertension and hypokalemia caused after fludrocortisone is taken.

Description

technical field [0001] The invention relates to an oral liquid for auxiliary treatment of congenital adrenal hyperplasia. Background technique [0002] Congenital adrenal hyperplasia (CAH) is a relatively common autosomal recessive genetic disease caused by congenital defects in enzymes required for corticosteroid synthesis. Insufficient synthesis of cortisol reduces the blood concentration, and the negative feedback stimulates the pituitary gland to secrete adrenocorticotropic hormone (ACTH), leading to hyperplasia of the adrenal cortex and excessive secretion of cortisol precursors such as 11-deoxycortisol and adrenal androsterone, etc. . The six types currently recognized are: 21-hydroxylase deficiency, 11β-hydroxylase deficiency, 17-hydroxylase deficiency, 3β-hydroxydehydrogenase deficiency, corticosterone methyloxidase deficiency and congenital lipid Qualitative adrenal hyperplasia. [0003] The clinical manifestations of the disease: 21-hydroxylase deficiency and 3-...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P5/38
CPCA61K36/804A61K9/0095A61K36/076A61K36/195A61K36/236A61K36/264A61K36/282A61K36/284A61K36/287A61K36/315A61K36/40A61K36/42A61K36/536A61K36/59A61K36/704A61K36/71A61K36/855A61K36/884A61K36/8945A61K2236/331A61K2236/39A61K2300/00
Inventor 朱法荣庄元华韩玉杰刘晨刘向红李晓梅康丽丽许群
Owner QILU CHILDRENS HOSPITAL OF SHANDONG UNIV
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