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artificial blood vessel

A technology of artificial blood vessels and blood flow, applied in the field of artificial blood vessels, can solve the problems of excellent kink resistance and blood leakage, and achieve the effect of excellent immobilization of vascular endothelial cells

Inactive Publication Date: 2018-02-06
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent Document 4 describes the invention of a fabric with excellent biocompatibility. However, although it does not exert a negative impact on the living body, since no ultrafine fibers are used, even if the fabric described in the document is directly transferred to an artificial blood vessel, it will not be affected. It can be said that cell fixation, blood leakage, and kink resistance are excellent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] As the polyester fiber constituting the inner layer of the tubular fabric, a microfiber multifilament yarn with a single yarn fineness of about 0.23 dtex and a total weave of 33 dtex was prepared, which was used as a warp and a weft during weaving.

[0072] As the polyester fiber constituting the outer layer of the tubular fabric, a multifilament yarn with a single yarn fineness of about 2.25 dtex and a total fineness of 56 dtex as a warp yarn and a monofilament yarn with a single yarn fineness of 33 dtex as a weft yarn were prepared.

[0073] Using the above-mentioned fibers, a tubular fabric was woven by a shuttle loom with a plain weave of two layers of warp and weft to form a tube with an inner diameter of 3 mm, and it was refined at 98°C. Next, it was dried at 120° C. with dry heat, a rod-shaped jig was inserted into the above-mentioned tube, and it was set in a cylindrical shape at 170° C., and then sterilized to obtain a tubular fabric. With respect to the obtained...

Embodiment 2

[0075] As the polyester fiber constituting the inner layer of the tubular fabric, a superfine multifilament yarn with a single yarn fineness of about 0.23 dtex and a total weave of 33 dtex is used as the warp yarn, and the single yarn fineness is about 1.38 in an alternate manner. dtex, a multifilament yarn with a total denier of 33 dtex (the superfine fiber multifilament content of the warp yarn is 50% by weight), and a microfiber multifilament yarn with a single yarn denier of about 0.23 dtex and a total weave of 33 dtex as a weft yarn (The microfiber multifilament content rate of the weft yarn was 100% by weight), and the same tubular fabric as described in Example 1 was produced.

[0076] With respect to the obtained tubular fabric, the cover factor, the average crossing angle S, cell fixation and kink resistance were evaluated. The results are shown in Table 1. The average intersection angle S was judged as "no intersection" in the same manner as in Example 1. It also h...

Embodiment 3

[0078] As the polyester fiber constituting the inner layer of the tubular fabric, a microfiber multifilament yarn with a single yarn fineness of about 0.084 dtex and a total weave of 53 dtex is prepared, and it is used as a warp and a weft during weaving. The same tubular fabric as described in Example 1.

[0079] With respect to the obtained tubular fabric, the cover factor, the average crossing angle S, cell fixation and kink resistance were evaluated. The results are shown in Table 1. The average intersection angle S was judged as "no intersection" in the same manner as in Examples 1 and 2. Cell immobilization is superior to that of Example 1 and has extremely good characteristics, and the kink resistance required for the artificial blood vessel is further improved compared to Examples 1 and 2.

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Abstract

Provides an artificial blood vessel that possesses many characteristics required for an artificial blood vessel and is excellent in the fixability of vascular endothelial cells. An artificial blood vessel with a tubular fabric structure, each of the warp and weft yarns constituting the inner layer in contact with the blood flow contains superfine fiber multifilaments with a cover factor of 1800 or more, and the superfine fiber multifilaments are single yarns with a fineness of 0.50 dtex or less In the ultrafine fiber multifilament, the individual ultrafine fiber monofilaments intersect each other, and when the average intersecting angle is S, S<25°.

Description

technical field [0001] The present invention relates to artificial blood vessels. More specifically, it relates to a fabric artificial blood vessel having a tubular fabric structure excellent in fixation of vascular endothelial cells. Background technique [0002] Artificial blood vessels are mainly used to replace diseased living blood vessels and form catheters or branches for adults, and to form branches for children. Therefore, artificial blood vessels are required to have good in vivo compatibility, non-toxicity, firmness without deterioration in the living body, flexibility, minimal blood leakage, good fixation of vascular endothelial cells, and the like. [0003] In particular, vascular endothelial cells often produce nitric oxide and prostaglandins to inhibit platelet aggregation, which are substances that prevent thrombus from forming in blood vessels by controlling platelet function and coagulation and fibrinolytic system. An extremely important feature that must...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06A61L27/50
CPCA61L27/507A61F2240/001A61F2/07A61F2/06A61F2210/0076A61F2230/0069D02G3/448D10B2509/06A61F2/02A61L27/50A61F2/0077A61F2002/0086
Inventor 土仓弘至山田谕门胁功治桑原厚司
Owner TORAY IND INC