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Compound adjuvant for animal vaccine and application of compound adjuvant

An adjuvant and vaccine technology, applied in the direction of medical preparations containing active ingredients, antibody medical ingredients, pharmaceutical formulations, etc., can solve the problems of reduced antigen titer, difficulty in preparing animal and vegetable oil adjuvants, and inactivation, so as to improve immunity Efficacy, beneficial to immune protection, effect of reducing side effects

Active Publication Date: 2016-06-22
CHINA ANIMAL HUSBANDRY IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology discloses a nanoemulsion adjuvant with a particle size between 10 and 200nm. During the preparation process, the vaccine needs to undergo a high-pressure homogeneous nano-treatment process, which may easily lead to a decrease in the titer of the antigen or even inactivation. The book mentions that animal and vegetable oils can be used, but does not provide experimental examples of animal and vegetable oil adjuvants, which makes the preparation of animal and vegetable oil adjuvants more difficult
[0006] None of the above-mentioned patents uses vegetable oil, polymers, and immune enhancers to prepare animal vaccine adjuvants

Method used

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  • Compound adjuvant for animal vaccine and application of compound adjuvant
  • Compound adjuvant for animal vaccine and application of compound adjuvant
  • Compound adjuvant for animal vaccine and application of compound adjuvant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The compound vaccine adjuvant described in the present embodiment is composed as follows by weight percentage:

[0068] Vegetable oil for injection:

[0069] Soybean oil for injection 70%

[0070] Emulsifier:

[0071] Lecithin 5%

[0072] Hexaglycerol Monooleate 1%

[0073] Auxiliary:

[0074] Propylene Glycol 1%

[0075] polymer:

[0076] Polyvinylpyrrolidone 2%

[0077] Polyfumarate-Sebacic Acid 0.8%

[0078] Aqueous solution for injection: 20%

[0079] Immune booster:

[0080] Echinacea Extract 0.2%.

Embodiment 2

[0082] The compound vaccine adjuvant described in the present embodiment is composed as follows by weight percentage:

[0083] Vegetable oil for injection:

[0084] Corn Oil for Injection 75%

[0085] Emulsifier:

[0086] Tween 854%

[0087] Tween 802%

[0088] Auxiliary:

[0089] Glycerin 1%

[0090] polymer:

[0091] Polylactic acid 2%

[0092] Mannan 0.5%

[0093] Aqueous solution for injection: 15%

[0094] Immune booster:

[0095] Interleukin - 20.5%.

Embodiment 3

[0097] The compound vaccine adjuvant described in the present embodiment is composed as follows by weight percentage:

[0098] Vegetable oil for injection:

[0099] Peanut Oil for Injection 50%

[0100] Emulsifier:

[0101] Ten Polyglyceryl Monooleate 8.5%

[0102] Lauryl Glucoside (APG1416) 2%

[0103] Auxiliary:

[0104] Propylene Glycol 2%

[0105] polymer:

[0106] Polycaprolactone 4%

[0107] Polyethylene glycol 8000 2.5%

[0108] Aqueous solution for injection: 30.9%

[0109] Immune booster:

[0110] Cimetidine 0.1%.

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Abstract

The invention relates to a vaccine adjuvant and particularly discloses a compound adjuvant for an animal vaccine. The compound adjuvant comprises raw materials in parts by weight as follows: 10-70 parts of vegetable oil for injection, 0.1-20 parts of an emulsifier, 1-10 parts of an additive, 0.01-10 parts of polymers and 0.01-5 parts of an immunopotentiator, wherein the polymers are selected from natural polymers and / or synthetic polymers. According to the animal vaccine prepared from the compound adjuvant, a synergistic effect is realized through compounding of the vegetable oil for injection, the polymers and the immunopotentiator, the immune efficacy of the animal vaccine is improved effectively, and immune protection of the animal vaccine is facilitated. Side effects of the vaccine adjuvant are reduced obviously in the aspect of animal safety compared with a mineral oil adjuvant.

Description

technical field [0001] The invention relates to a vaccine adjuvant, in particular to a composite adjuvant for animal vaccines. Background technique [0002] An adjuvant refers to a substance that can be applied simultaneously or in advance with an antigen to enhance the body's immune response to the antigen, or to change the type of immune response. Adjuvants play a vital role in vaccines. They can act on both antigens and the body. Appropriate use of adjuvants can regulate or even change the type of antigen-specific humoral and / or cellular immune responses produced by the body's immune system. For the body, the adjuvant is an exogenous substance. In addition to the required immunostimulatory effect, the adjuvant is also likely to cause adverse reactions. The benefit of adding adjuvants to vaccine formulations to enhance vaccine immunogenicity must be weighed against the risk of adverse reactions. Local adverse reactions include inflammation, nodules, abscess, etc. Systemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39
CPCA61K39/39
Inventor 潘京学王贺民潘春刚严石杨君敬
Owner CHINA ANIMAL HUSBANDRY IND
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