A kind of sustained-release broad-spectrum antibacterial agent and preparation method thereof

An antibacterial and sustained-release technology, applied in the field of sustained-release broad-spectrum antibacterial agents, can solve the problems of unobtainable raw materials, volatile iodine, allergic reactions, etc. Bacterial effect

Active Publication Date: 2018-05-01
NANOLATTIX BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, iodine is highly irritating to the skin and mucous membranes, and iodine is volatile and unstable, and can cause allergic reactions
Povidone iodine, which emerged in the 1960s, improved iodine and overcome the problem that some iodine is volatile and irritating to the skin and mucous membranes. However, the effective iodine content in povidone iodine is not high, and the bactericidal effect is not great , and the price is relatively expensive, and the raw materials are not easy to obtain

Method used

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  • A kind of sustained-release broad-spectrum antibacterial agent and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0015] A slow-release broad-spectrum antibacterial agent, the material includes by weight: butyl chitosan 50%, medicinal iodine 10%, distilled water 30%, potassium iodate 5%, sodium carbonate-sodium bicarbonate buffer solution 5% %.

[0016] The preparation method of the above-mentioned slow-release broad-spectrum antibacterial agent is as follows: (1) take 1 part of medicinal iodine and 5 parts of butyl chitosan, mix fully and uniformly, grind until the diameter is 1.2-1.8 mm, and obtain brown-black powder; (2) Move it into a wide-mouth container, heat it with an oil bath at 96 degrees Celsius, and stir continuously for 18 hours until the wet starch test paper is placed in the mouth of the container for 30 seconds until the test paper does not show blue, indicating that the uncomplexed free iodine has been removed. (3) Add 3 parts of water to form an aqueous solution; (4) Add 0.5 parts of potassium iodate to the aqueous solution; (5) Add 0.5 parts of sodium carbonate-sodium b...

Embodiment 2

[0018] A slow-release broad-spectrum antibacterial agent, the material includes by weight: butyl chitosan 45%, medicinal iodine 10%, distilled water 35%, potassium iodate 5%, sodium carbonate-sodium bicarbonate buffer solution 5% %.

[0019] The preparation method of the above-mentioned slow-release broad-spectrum antibacterial agent is as follows: (1) take 1 part of medicinal iodine and 4.5 parts of butyl chitosan, mix them fully and uniformly, grind until the diameter is 1.2-1.8 mm, and obtain a brown-black powder; (2) Move it into a wide-mouth container, heat it with an oil bath at 96 degrees Celsius, and stir continuously for 18 hours until the wet starch test paper is placed in the mouth of the container for 30 seconds until the test paper does not show blue, indicating that the uncomplexed free iodine has been removed. (3) Add 3.5 parts of water to form an aqueous solution; (4) Add 0.5 parts of potassium iodate to the aqueous solution; (5) Add 0.5 parts of sodium carbona...

Embodiment 3

[0021] A kind of sustained-release broad-spectrum antibacterial agent, described material comprises by weight: butyl chitosan 40%, medicinal iodine 10%, distilled water 40%, potassium iodate 5%, sodium carbonate-sodium bicarbonate buffer solution 5%.

[0022] The preparation method of the above-mentioned slow-release broad-spectrum antibacterial agent is as follows: (1) take 1 part of medicinal iodine and 4 parts of butyl chitosan, mix them fully and uniformly, grind until the diameter is 1.2-1.8 mm, and obtain a brown-black powder; (2) Move it into a wide-mouth container, heat it with an oil bath at 96 degrees Celsius, and stir continuously for 18 hours until the wet starch test paper is placed in the mouth of the container for 30 seconds until the test paper does not show blue, indicating that the uncomplexed free iodine has been removed. (3) Add 4 parts of water to form an aqueous solution; (4) Add 0.5 parts of potassium iodate to the aqueous solution; (5) Add 0.5 parts of ...

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Abstract

The invention discloses a slow-release spectrum antibacterial agent. According to the technical scheme, the slow-release spectrum antibacterial agent is characterized by comprising 40%-50% of butylchitosan, 10%-15% of medicinal iodine, 10%-40% of distilled water, 1%-5% of potassium iodate and 1%-5% of a sodium carbonate-sodium bicarbonate buffer solution. Through brand-new chelation of carrier butylchitosan and iodine, the antibacterial effect of the antibacterial agent is improved, the iodine content is increased, and the sterilization effect is good. Besides, butylchitosan has a strong and effective antibacterial effect, is clean and easy to obtain and also has a slow release effect, raw materials are widely sourced, and the cost is low.

Description

technical field [0001] The present invention relates to an antibacterial agent, more specifically, it relates to a slow-release broad-spectrum antibacterial agent. Background technique [0002] Due to its poor water solubility, iodine is dissolved in ethanol as an antibacterial agent for clinical disinfection and sterilization. Iodine has been widely used due to its advantages of high efficiency and broad spectrum. However, iodine is highly irritating to the skin and mucous membranes, and iodine is volatile and unstable, and can cause allergic reactions. Povidone iodine, which emerged in the 1960s, improved iodine and overcome the problem that some iodine is volatile and irritating to the skin and mucous membranes. However, the effective iodine content in povidone iodine is not high, and the bactericidal effect is not great , and the price is relatively expensive, and the raw materials are not easy to obtain. Therefore increase antibacterial effect, improve the content of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/16A01N59/12A01P1/00
CPCA01N43/16A01N59/12A01N2300/00
Inventor 杨胜祥傅深渊况燚
Owner NANOLATTIX BIOTECH CO LTD
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