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Preparation method of heat clearing and detoxifying soluble powder

A heat-clearing and detoxifying, soluble technology, applied to medical preparations containing active ingredients, antipyretics, powder delivery, etc., can solve the problems of increasing drug production costs, demanding equipment requirements, time-consuming, etc., to facilitate large-scale promotion, The effect of low equipment requirements and simple process

Inactive Publication Date: 2016-07-06
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The alcohol precipitation process is not only time-consuming and energy-consuming, but also requires harsh equipment, which greatly increases the production cost of drugs

Method used

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  • Preparation method of heat clearing and detoxifying soluble powder
  • Preparation method of heat clearing and detoxifying soluble powder
  • Preparation method of heat clearing and detoxifying soluble powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Weigh 67kg of raw gypsum, 14kg of honeysuckle, 10kg of scrophulariaceae, 8kg of rehmannia, 7kg of forsythia, 7kg of gardenia, 6kg of sweet dithin, 8kg of scutellaria baicalensis, 6kg of gentian, 6kg of Radix Radix, 6kg of Anemarrhena, and 6kg of Radix Ophiopogon japonicus. Twelve herbs;

[0019] (2) For the above twelve flavors, except for honeysuckle and scutellaria, add 1510L of water to soak for 1 hour, and boil for 1 hour for the first time (add honeysuckle and scutellaria baicalensis after half an hour of boiling); add 1208L of water for the second time Boil for 40 minutes, filter to obtain the extract;

[0020] (3) Combine the extracts and concentrate to 1510L; (4) add 60.4L of 1% chitosan solution to the concentrated solution at 80°C under stirring, and let stand for 3h;

[0021] (5) Filtrate, add 30.2 L of 1% sodium alginate solution to the filtrate, and let stand for 6 hours;

[0022] (6) Filtrate, concentrate the filtrate to a relative density of 1.1 (80...

Embodiment 2

[0025] (1) Weigh 67kg of raw gypsum, 14kg of honeysuckle, 10kg of scrophulariaceae, 8kg of rehmannia, 7kg of forsythia, 7kg of gardenia, 6kg of sweet dithin, 8kg of scutellaria baicalensis, 6kg of gentian, 6kg of Radix Radix, 6kg of Anemarrhena, and 6kg of Radix Ophiopogon japonicus. Twelve herbs;

[0026] (2) For the above twelve flavors, except for honeysuckle and scutellaria, add 1510L of water to soak for 1 hour, and boil for 1 hour for the first time (add honeysuckle and scutellaria baicalensis after half an hour of boiling); add 1208L of water for the second time Boil for 40 minutes, filter to obtain the extract;

[0027] (3) Combine extracts and concentrate to 755L;

[0028] (4) Add 75.5 L of 1% chitosan solution to the concentrated solution at 60°C under stirring, and let it stand for 3 hours;

[0029] (5) Filtrate, add 37.75 L of 1% sodium alginate solution to the filtrate, and let it stand for 6 hours;

[0030] (6) Filtrate, concentrate the filtrate to a relative ...

Embodiment 3

[0033] (1) Weigh 67kg of raw gypsum, 14kg of honeysuckle, 10kg of scrophulariaceae, 8kg of rehmannia, 7kg of forsythia, 7kg of gardenia, 6kg of sweet dithin, 8kg of scutellaria baicalensis, 6kg of gentian, 6kg of Radix Radix, 6kg of Anemarrhena, and 6kg of Radix Ophiopogon japonicus. Twelve herbs;

[0034] (2) For the above twelve flavors, except for honeysuckle and scutellaria, add 1510L of water to soak for 1 hour, and boil for 1 hour for the first time (add honeysuckle and scutellaria baicalensis after half an hour of boiling); add 1208L of water for the second time Boil for 40 minutes, filter to obtain the extract;

[0035] (3) Combine the extracts and concentrate to 1057L;

[0036] (4) Add 74L of 1% chitosan solution to the concentrated solution at 60°C under stirring, and let it stand for 3 hours;

[0037] (5) Filtrate, add 37L of 1% sodium alginate solution to the filtrate, and let it stand for 6 hours;

[0038] (6) Filtrate, concentrate the filtrate to a relative de...

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Abstract

The invention discloses a preparation method of heat clearing and detoxifying soluble powder. The soluble powder is prepared on the basis of a veterinary use preparation ''Summer-heat clearing mixture'' through dosage form change and technology optimization. The drug stability and practicability are improved by changing a liquid preparation into a solid preparation, and the storage and transport are easy. A preparation technology of traditional Chinese medicine soluble powder is optimized. Chitosan and sodium alginate are combined to remove insoluble components of precipitation, insoluble suspension particles, tannin and colloid in an extracted liquid. The water soluble property of the soluble powder is improved, the administration of drinking water is facilitated, and the practicality of the drug is enhanced. The heat clearing and detoxifying soluble powder prepared by the method has the high baicalin retention rate, good water soluble property and stable quality, and is easy to store and easy to transport. The method of the invention realizes alcohol-free production. The technology is simple. The production period is short. The equipment requirement is low, and the cost is low. The preparation method of the heat clearing and detoxifying soluble powder facilitates large scale popularization, exploitation and application.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese veterinary medicine, and in particular relates to a preparation method of heat-clearing and detoxifying soluble powder. Background technique [0002] "Chinese Veterinary Pharmacopoeia" 2010 edition of Qingjie mixture: 670g gypsum, 140g honeysuckle, 100g scrophulariaceae, 80g scutellaria baicalensis, 80g rehmannia root, 70 parts forsythia, 70g gardenia, 60g gentian, 60g sweet dithin, Banlangen 60g, Anemarrhena 60g, Ophiopogon japonicus 60g, the extraction method is: the above 12 flavors, except honeysuckle and scutellaria baicalensis, soak the other 10 flavors in water for 1 hour, then decoct 2 times, the first time for 1 hour (decoction for half an hour) Then add honeysuckle and scutellaria baicalensis), decoct for 40 minutes for the second time, filter, combine the filtrate, concentrate the filtrate to a relative density of about 1.17 (90°C), add ethanol to make the alcohol content re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/14A61P29/00A61P31/04A61K33/06
Inventor 彭江宁李旭东刘爱玲
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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