Preparation method for artificial bone scaffold capable of loading drugs according to layers and quantity

Abstract

The invention provides a preparation method for an artificial bone scaffold capable of loading drugs according to layers and quantity.The method comprises the steps that a rapid molding method through a biological three-dimensional extrusion molding machine is adopted, different drugs and calcium phosphate cement are mixed and embedded, an artificial bone scaffold three-dimensional CAD model is processed by means of a computer, bio-adhesive and mixed powder are mixed to be uniform to be put into the biological three-dimensional extrusion molding machine, and a bone scaffold mold which accords with bone porosity of an individual patient, has the anti-infection characteristic and is good in biocompatibility is obtained through extrusion molding.According to the preparation method for the artificial bone scaffold, the different drugs can be selectively sprayed on the specific portions of an artificial bone according to needs of the patients; by means of the arrangement of different gradients for different drugs, various drugs with different contents can be loaded on different portions of the same drug-loading artificial bone scaffold, and complex local drug combined application is formed.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a method for preparing layered component artificial bone brackets through calcium phosphate bone cement loaded with various drugs. Background technique [0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. Currently commonly used bone repair materials include autologous bone and allogeneic bone. The source of autologous bone is limited, and there are many postoperative complications, which increase the trauma and pain of the patient; the exogenous bone will cause rejection of the body, and there are problems such as loosening and fracture, and the success rate of transplantation is low. In the process of repairing traumatic bone damage, it is very easy to cause infection. Whether the replacement bone graft is successful or not is closely related to whether it is infec...

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the use of drug-loaded calcium phosphate bone cement to prepare drug-loaded artificial bone scaffolds through a biological three-dimensional extrusion molding machine. At the same time, according to the needs of patients, multiple drugs are loaded, and the amount of each drug can be adjusted according to the needs of patients. It can be added on demand, and the effect of hierarchical release can be achieved through the different order of drug embedding.