Heat clearing and pain alleviating veterinary flunixin meglumine coating agent for animals and preparation method thereof

A technology of flunixin meglumine and film coating agent, applied in the field of animal pharmacy, can solve the problems of animal stress, difficult to eliminate, time-consuming and labor-intensive, etc., and achieves the effects of less stress, significant treatment effect, and convenient use.

Active Publication Date: 2016-07-20
江苏欧克动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, flunixin meglumine for veterinary use is only in the form of injection. When using it, the animal must be fixed for injection, which is time-consuming and laborious, and it is easy to cause stress to the animal. It is not easy to eliminate the side effects

Method used

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  • Heat clearing and pain alleviating veterinary flunixin meglumine coating agent for animals and preparation method thereof
  • Heat clearing and pain alleviating veterinary flunixin meglumine coating agent for animals and preparation method thereof
  • Heat clearing and pain alleviating veterinary flunixin meglumine coating agent for animals and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Flunixin meglumine coating agent for animal heat-clearing and analgesic is preferably a coating agent made of the following raw materials: flunixin meglumine 100g / L, polyvinyl alcohol-12430g / L, water-soluble azone 30mL / L, N-methylpyrrolidone 100mL / L, glycerin 100mL / L, solvent is 0.05M pH7.4 Tris-HCl buffer.

[0035] The production method that above-mentioned each component is made film-coating agent of the present invention is (calculated by 1000 milliliter volume):

[0036] ① Prepare 0.05mol / l Tris hydrochloric acid buffer solution (pH7.4) at room temperature of 25°C;

[0037] ② Weigh 30g of polyvinyl alcohol-124, put it into a clean beaker with an appropriate volume, add 500ml of 0.05M Tris hydrochloric acid buffer solution to soak for 2 hours, put it in a water bath at 80°C and stir slowly to dissolve completely, and obtain a solution of polyvinyl alcohol-124, keep Reserve in a water bath at 80°C;

[0038] ③ Measure 100ml of glycerin, slowly add the solution prepa...

Embodiment 2

[0046] 1. Acute toxicity test of flunixin meglumine (LD50 Determination)

[0047] (1) intramuscular injection of LD in mice 50 determination

[0048] Pre-test: According to the data analysis of flunixin meglumine, the dose of the high-dose group to be tested is 600 mg / kg, and 5 groups are set according to the multiple of 3 to 5 times, and the doses of each group are 600 mg / kg and 200 mg / kg respectively. kg, 150mg / kg, 120mg / kg, 66.7mg / kg, groups 1-5 from low dose to high dose. Select 4 mice for every group, half male and half male, intramuscularly inject 0.1ml / 10g solution of each dosage group, select another 4 mice, intramuscularly inject 0.1ml / 10g blank solvent not containing flunixin meglumine, observe each The death situation of small white mice in each group was counted and the results were analyzed.

[0049] Pre-test results (see Table 1)

[0050] Table 1 Different doses of flunixin meglumine injection death statistics of mice

[0051]

[0052] From the preliminar...

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Abstract

The invention discloses a heat clearing and pain alleviating veterinary flunixin meglumine coating agent for animals. The coating agent is prepared from the following raw materials: 80 to 120 g / L of flunixin meglumine, 20 to 40 g / L of polyvinyl alcohol-124, 20 to 40 mL / L of water-soluble azone, 80 to 120 mL / L of N-methylpyrrolidone, and 80 to 120 mL / L of glycerin, and the solvent adopts a Tris-HCL(Tris(hydroxymethyl) aminomethane hydrochloride) buffer solution. The invention further discloses a preparation method of the coating agent. A transdermal agent prepared by the invention has the advantages of good film-forming property, capability of slowly releasing medicines, relieving fever and stopping pain and lasting curative effect, small stress and the like. The formula and the preparation method of the coating agent are unique, the treatment effect is remarkable, a protective film can be formed, the medicines at the inner layer of the film are permeated and absorbed, and the outer layer of the film has a protecting effect, and cannot fall off automatically, so that the coating agent has incomparable advantages in comparison with a pouring agent.

Description

technical field [0001] The invention relates to a flunixin meglumine coating agent for clearing heat and relieving pain in animals such as pigs and rabbits and a preparation method thereof, belonging to the technical field of animal medicines. Background technique [0002] Fever is a common symptom of domestic animals. It not only leads to the decline of physiological functions, but also inhibits the growth of livestock and reduces production performance. It will also occur mixed with infectious diseases, causing the death of piglets and sows, and the formation of dead pigs. Fever is often accompanied by pain, especially redness, swelling, pain and dysfunction caused by inflammation, which seriously affects animal production and brings economic losses to the breeding industry. Therefore, the use of antipyretic drugs is more frequent. At present, Analgin Injection and Aminopyrene, which are commonly used for antipyretic, have less significant antipyretic effects, and need to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/44A61K47/10A61K47/18A61K47/22A61K47/32A61P29/00
CPCA61K9/0014A61K9/7015A61K31/44A61K47/10A61K47/18A61K47/22A61K47/32
Inventor 戴鼎震陈俊红陈海华张志成蒋加进仇明生张淼李云海武毅
Owner 江苏欧克动物药业有限公司
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