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Combined drug for treating periodontitis

A technique for periodontitis and drugs, applied in the field of combination drugs for the treatment of periodontitis, to achieve good fluidity, maintain drug concentration, and significant therapeutic effects

Inactive Publication Date: 2016-07-27
HONGYUN HONGHE TOBACCO (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for acute infection of periodontal tissue and some specific types of periodontal disease (such as periodontitis with diabetes), although mechanical therapy supplemented with local or systemic drug therapy can receive certain curative effect

Method used

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  • Combined drug for treating periodontitis
  • Combined drug for treating periodontitis

Examples

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Embodiment Construction

[0015] In order to have a further understanding and understanding of the structural features and the achieved effects of the present invention, the preferred embodiments and accompanying drawings will be used for a detailed description, as follows:

[0016] A combined medicine for treating periodontitis, which comprises weighing 1 to 20 parts of minocycline hydrochloride, 15 to 100 parts of solanesol and 1000 parts of glycerin in parts by weight, and mixing minocycline hydrochloride, solanesol and Glycerin is mixed to obtain a suspension, which is a medicine for treating periodontitis. When in use, the medicine for treating periodontitis is injected into the periodontal pocket with a flat needle, and used before going to bed, once a day.

[0017] Construction of mouse periodontitis model:

[0018] Select 90 clean-grade male SD rats provided by Jiancheng Bill Animal Farm in Jianyang City, Sichuan Province, 6 weeks old, weighing 180-220g; randomly divided into 3 groups, 30 norma...

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PUM

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Abstract

The invention discloses a combined drug for treating periodontitis. The combined drug is prepared from, by weight, 1-20 parts of minocycline hydrochloride, 15-100 parts of solanesol and 1,000 parts of glycerol. The combined drug for treating periodontitis is supplemented by an antioxidant drug, so that the curative effect is more remarkable.

Description

technical field [0001] The invention belongs to the fields of medicine and biology, and in particular relates to a combination medicine for treating periodontitis. Background technique [0002] Periodontitis is a chronic infectious disease caused by specific bacteria. Excessive reactive oxygen species produced by periodontal tissue stimulated by bacteria can cause and aggravate periodontal tissue damage. Reactive oxygen species (reactive oxygen species, ROS) is a general term for oxygen-containing free radicals related to oxygen metabolism in organisms and peroxides that are easy to form free radicals. DNA and lipopolysaccharides (Lipopolysaccharides, LPS) in bacteria can act on gingival fibroblasts to produce inflammatory cytokines; bacteria and inflammatory cytokines can accelerate the activation of ROS by causing the activation of macrophages and neutrophils produce. The generated ROS oxidatively damages the periodontal tissue, promotes the occurrence and development of...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/045A61K9/10A61K47/10A61P1/02
CPCA61K31/65A61K9/10A61K31/045A61K47/10
Inventor 汪显国李庆华唐丽唐军和红兵任晓斌周志宏杨晶津崔宇翔
Owner HONGYUN HONGHE TOBACCO (GRP) CO LTD
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