Amphiphilic binary molecular brush polymer and its constructed pH-responsive unimolecular nanomicelles

A nanomicelle, binary molecule technology, applied in nanotechnology, medical preparations with inactive ingredients, emulsion delivery, etc. controllable effect

Active Publication Date: 2019-03-22
国科广化(南雄)新材料研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the research about graft polymer preparation unimolecular micelle is relatively rare, relatively speaking, most graft copolymers are all used to prepare multimolecular micelles or capsules, as the patent CN103289099A report is prepared by graft copolymer The obtained acid-sensitive nanocapsules, the multi-channel pH-responsive nanocapsules prepared by the emulsion self-assembly method reported in patent CN 103059312A, the photocrosslinked nano-paraffin phase-change energy storage capsules reported in patent CN104645908A, reported in patent CN102911370A Nanocapsules constructed of amphiphilic ternary molecular brush polymers, if the capsules are not further structurally locked, they all have the problem of being easily disintegrated by the external environment
In addition, the photocrosslinked nano-paraffin phase-change energy storage capsule reported by CN104645908A and the nanocapsule constructed by the amphiphilic ternary molecular brush polymer reported by the patent CN102911370A do not have response performance.

Method used

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  • Amphiphilic binary molecular brush polymer and its constructed pH-responsive unimolecular nanomicelles
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  • Amphiphilic binary molecular brush polymer and its constructed pH-responsive unimolecular nanomicelles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] An amphiphilic binary molecular brush polymer is prepared by the following steps:

[0040] (1)P(GMA-N 3 ) main chain synthesis

[0041] According to the ratio of substances, take 1 part of 2-bromoisobutyric acid monomethoxyethyl ester initiator, 700 parts of glycidyl methacrylate (GMA), 600 parts of diphenyl ether, 1 part of CuBr and 1 part of N, N,N',N',N"-Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at 30°C under nitrogen protection for 3 hours to obtain polyglycidyl methacrylate with a degree of polymerization (DP) of 260 (PGMA).

[0042] According to the ratio of substances, take 1 part of PGMA (DP=260), 1000 parts of NaN 3 , 130,000 parts of dimethylformamide (DMF) and 6 parts of AlCl 3 , and reacted at 50°C for 24 hours to obtain the main chain polymer P(GMA-N 3 ).

[0043] (2) Synthesis of two side chains

[0044] Synthesis of hydrophilic polymer side chains: according to the ratio of substances, get 1 part of monomethoxypolyethylene gly...

Embodiment 2

[0052] The preparation method and raw material composition are the same as in Example 1, and only the main chain length of the amphiphilic binary molecular brush polymer in Example 1 is adjusted to prepare pH-responsive single-molecule nanomicelles of different sizes. The lengths of the three main chains are shown in Table 1.

[0053] Table 1 Effect of main chain length on the size of unimolecular micelles

[0054]

[0055]

[0056] It can be seen from Table 1 that pH-responsive unimolecular nanomicelles with different particle sizes can be prepared by changing the length of the main chain.

Embodiment 3

[0058] The preparation method and raw materials are the same as those in Example 1. By adjusting the total grafting ratio of the polymer, pH-responsive single-molecule nanomicelles with different morphologies can be obtained, as shown in Table 2.

[0059] Table 2 Effect of total grafting ratio on the morphology of micelles

[0060]

[0061] It can be seen from Table 2 that when the grafting rate is high, the side chains become crowded, which leads to the inability of the main chain to bend, and the monomolecular morphology gradually transitions from spherical to rod-like.

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Abstract

The invention belongs to the field of functional polymer nanomaterials, and particularly discloses an amphiphilic binary molecular brush polymer and pH responsive unimolecule nanomicelles constructed by the same.The polymer has the following general structural formula of A-g-(B-r-C), wherein g represents grafting, r represents random copolymerization, A represents a polymer main chain, B represents a pH responsive a macromolecule side chain, C represents a hydrophilic macromolecule side chain, and the side chain B and the side chain C are randomly grafted to the main chain A.The amphiphilic binary molecular brush polymer N,N-dimethylformamide solution is slowly added into water with the pH being 8 dropwise and stirred for 2 h to obtain the pH responsive unimolecule nanomicelles.The problem that traditional polymolecular micelles are disintegrated when the concentration is lower than critical micelle concentration or under the action of ionic strength and large shear force is solved, and micelle stability is improved.The particle size of the unimolecule nanomicelles can be adjusted according to length of the main chain, and therefore controllability of the micelle size is improved.

Description

technical field [0001] The invention belongs to the field of functional macromolecular nanomaterials, and in particular relates to an amphiphilic binary molecular brush polymer and a pH-responsive single-molecule nanomicelle constructed therefrom. Background technique [0002] Polymer nanomicelle is one of the most common drug carriers, which has aroused extensive interest of researchers in the field of biomedicine in recent years. Traditional multimolecular micelles really play a great role in solubilizing drugs, and were once highly valued by people. [0003] However, people have gradually discovered that the traditional multimolecular micelles are a dynamic equilibrium structure, and its structure will change with the change of the external environment. When the concentration of the polymer is lower than the CMC, the micelles disassemble. After the drug-loaded micelles enter the human body through intravenous injection, the micelles are largely diluted. In addition, fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34C08G81/02C08J3/00C08L87/00B82Y40/00A61K9/10
CPCA61K9/1075A61K47/34B82Y40/00C08G81/025C08J3/00C08J2387/00
Inventor 胡继文莫杨妙刘锋宋骏林树东涂圆圆
Owner 国科广化(南雄)新材料研究院有限公司
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