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An amphiphilic ternary molecular brush polymer and its worm-like unimolecular micelles

A technology of unimolecular micelles and hydrophilic polymers, applied in medical preparations of non-active ingredients, organic compound/hydride/coordination complex catalysts, emulsion delivery, etc., can solve the problem of being easily affected by the external environment However, problems such as disintegration occur, achieving the effect of novel structure and improved controllability

Active Publication Date: 2019-02-01
国科广化(南雄)新材料研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, most of the current research on graft copolymers is mainly based on the preparation of multimolecular micelles / capsules, such as the acid-sensitive nanocapsules prepared by graft copolymers reported in patent CN103289099A, and the adoption of patent CN 103059312 A reports A multi-channel pH-responsive nanocapsule prepared by the emulsion self-assembly method, the photo-crosslinked nano-paraffin phase-change energy storage capsule reported in the patent CN 104645908 A, if the capsule structure is not further locked, they all have the possibility of being easily affected by the external environment. disintegration

Method used

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  • An amphiphilic ternary molecular brush polymer and its worm-like unimolecular micelles
  • An amphiphilic ternary molecular brush polymer and its worm-like unimolecular micelles
  • An amphiphilic ternary molecular brush polymer and its worm-like unimolecular micelles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A kind of amphiphilic ternary high graft density polymer is prepared by the following steps:

[0046] (1)P(GMA-N 3 ) main chain synthesis

[0047] According to the ratio of substances, take 1 part of 2-bromoisobutyric acid monomethoxyethyl ester initiator, 700 parts of glycidyl methacrylate (GMA), 600 parts of diphenyl ether, 1 part of CuBr and 1 part of N, N,N',N',N"-Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at 30°C under nitrogen protection for 3 hours to obtain polyglycidyl methacrylate with a degree of polymerization (DP) of 260 (PGMA).

[0048] According to the ratio of substances, take 1 part of PGMA (DP=260), 1000 parts of NaN 3 , 130,000 parts of dimethylformamide (DMF) and 6 parts of AlCl 3 , reacted at 50°C for 24 hours to obtain P(GMA-N 3 ), as the main chain.

[0049] (2) Synthesis of three side chains

[0050] Synthesis of hydrophilic polymer side chains: according to the ratio of substances, get 1 part of monomethoxypolyethylen...

Embodiment 2

[0058] The preparation method and raw material composition are the same as in Example 1, only the main chain length of the amphiphilic worm-like ternary graft polymer in Example 1 is adjusted, and nanomicelles of different sizes can be prepared. The lengths of the three main chains are shown in Table 1.

[0059] Table 1 Effect of main chain length on the length of unimolecular micelles

[0060]

[0061] It can be seen from Table 1 that by changing the length of the main chain, worm-like unimolecular nanomicelles with different lengths can be prepared.

Embodiment 3

[0063] The preparation method and raw materials were the same as in Example 1. The mass ratio of the hydrophilic and hydrophobic side chains of the polymer was adjusted to explore the effect of the mass ratio of the hydrophilic and hydrophobic side chains on the stability of the micelles. The results are shown in Table 2. Here, the hydrophobic side chains are PCEMA and PtBA.

[0064] Table 2 Effect of mass ratio of hydrophilic and hydrophobic side chains on the stability of micelles

[0065]

[0066] It can be seen from Table 2 that when the hydrophobic side chain is greater than 60% of the total side chain mass, the polymer cannot obtain stable unimolecular micelles through the method of Example 1, and thus precipitates out.

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Abstract

The invention belongs to the field of self-assembled polymer materials, and specifically relates to an amphiphilic three-component molecular brush polymer and its constructed worm-like single-molecule micelles. The general structural formula of the polymer is A‑g‑(B‑r‑C‑r‑D), where g represents grafting, r represents random copolymerization, A is the polymer main chain, and B is the lipophilic polymer side chain. , C is a polymer side chain with a photo-crosslinked structure, D is a hydrophilic polymer side chain, and side chains B, C, and D are randomly grafted on the main chain A. The worm-like single-molecule nanomicelles are obtained by slowly adding deionized water to the N,N-dimethylformamide solution of the above-mentioned amphiphilic polymer, and then dialyzing to remove the N,N-dimethylformamide. . The worm-like single-molecule micelles prepared by the present invention have a novel structure, and can change the morphology and size of the micelles by changing the grafting rate and the molecular weight of the precursor polymer, and have extremely high controllability.

Description

technical field [0001] The invention belongs to the field of self-assembled polymer materials, and in particular relates to an amphiphilic ternary molecular brush polymer and worm-like unimolecular micelles constructed therefrom. Background technique [0002] With the emergence of new synthetic reaction technologies (such as living radical polymerization, click chemistry, etc.), the technology of preparing functional nanomicelles through polymers has also emerged in large numbers. As one of the most common methods for preparing micelles, the self-assembly method can control the shape, size and performance of micelles simply by adjusting the composition of block copolymers, the weight ratio of each part, and the length of the chain. [0003] At present, the micelles prepared by self-assembly of block copolymers and graft copolymers are usually multimolecular micelles. Traditional multimolecular micelles really play a great role in solubilizing drugs, and were once highly val...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02C08F120/32C08F8/30C08G65/332C08F120/18C08F8/12C08F120/28C08F8/14C08J3/00C08L87/00A61K9/107A61K47/34B01J19/00B01J31/06
CPCA61K47/34B01J19/0093A61K9/1075C08F8/12C08F8/30C08F120/18C08F120/28C08F120/32C08G65/3322C08G81/025C08J3/00B01J31/063C08G2650/04C08G2650/60C08J2387/00B01J35/23C08F8/14
Inventor 胡继文莫杨妙刘锋宋骏林树东涂圆圆
Owner 国科广化(南雄)新材料研究院有限公司
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