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Compound preparation for treating gastric ulcer

A technology for compound preparations and gastric ulcers, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of poor patient adaptability and difficulty in taking care of multiple aspects of curative effect, and achieve remarkable results , treatment of gastric ulcer, comprehensive curative effect

Inactive Publication Date: 2016-08-03
QINGDAO BAIRUIJI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, the current treatment of gastric ulcer often requires multiple drugs to be used in combination, which is not only difficult to take into account the curative effect, but also has poor patient adaptability.

Method used

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  • Compound preparation for treating gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035] 0.02 parts of omeprazole, 0.2 parts of aluminum sulfate, 10 parts of β-cyclodextrin, 20 parts of curcuma,

[0036] Salvia 5 parts, Fritillaria 5 parts, Hedyotis diffusa 15 parts, chitosan 50 parts.

[0037] Preparation Process:

[0038] (1) Take β-cyclodextrin, add water and grind it into a paste; take omeprazole, add enough ethanol, ultrasonically dissolve it, and then add it dropwise to the above-mentioned paste β-cyclodextrin, grind it while dripping, add dropwise Continue to grind after finishing, the grinding time is 20min, and dry to obtain omeprazole inclusion compound;

[0039] (2) Weigh Curcuma, Danshen, Fritillaria and Hedyotis diffusa in proportion, add 6 times the volume of 80% ethanol to reflux and extract for 3 times, each time for 2 hours, to obtain alcohol extraction residue and extract, and concentrate the extract, Obtain the alcohol extract, set aside;

[0040] (3) Remove the above-mentioned ethanol extraction residue, add 8 ...

Embodiment 2

[0044] prescription:

[0045] 0.02 parts of omeprazole, 0.6 parts of aluminum sulfate, 20 parts of α-cyclodextrin, 30 parts of curcuma,

[0046] 15 parts of Danshen, 20 parts of Fritillaria, 25 parts of Hedyotis diffusa, 100 parts of sodium carboxymethyl cellulose.

[0047] Preparation Process:

[0048] (1) Take α-cyclodextrin, add water and grind it into a paste; take omeprazole, add enough ethanol, ultrasonically dissolve it, and then add it dropwise to the above-mentioned α-cyclodextrin paste, grind it while dripping, add dropwise After finishing, continue to grind, the grinding time is 40min, and dry to obtain omeprazole inclusion compound;

[0049] (2) Weigh Curcuma, Danshen, Fritillaria japonicus and Hedyotis diffusa in proportion, add 10 times the volume of 60% ethanol to reflux and extract once, each time for 2 hours, to obtain alcohol extraction residue and extract, and concentrate the extract, Obtain the alcohol extract, set aside;

[0050] (3) Remove the above-m...

Embodiment 3

[0054] prescription:

[0055] 0.02 parts of omeprazole, 0.4 parts of aluminum sulfate, 15 parts of α-cyclodextrin, 25 parts of curcuma,

[0056] 10 parts of Danshen, 12.5 parts of Fritillaria, 20 parts of Hedyotis diffusa, and 75 parts of ethyl cellulose.

[0057] Preparation Process:

[0058] (1) Take α-cyclodextrin, add water and grind it into a paste; take omeprazole, add enough ethanol, ultrasonically dissolve it, and then add it dropwise to the above-mentioned α-cyclodextrin paste, grind it while dripping, add dropwise Continue to grind after finishing, the grinding time is 30min, and dry to obtain omeprazole inclusion compound;

[0059] (2) Weigh Curcuma, Danshen, Fritillaria and Hedyotis diffusa in proportion, add 8 times the volume of 70% ethanol to reflux and extract twice, each time for 2 hours, to obtain alcohol extraction residue and extract, and concentrate the extract, Obtain the alcohol extract, set aside;

[0060] (3) Remove the above-mentioned ethanol extr...

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Abstract

The invention provides a compound preparation for treating gastric ulcer. The compound preparation is prepared from the following raw materials in parts by weight: 0.02 part of omeprazole, 0.2 to 0.6 part of aluminium sulphate, 10 to 20 parts of cyclodextrin, 20 to 30 parts of curcuma zedoary, 5 to 15 parts of salvia miltiorrhizae, 5 to 20 parts of thunberg fritillary bulb, 15 to 25 parts of hedyotis diffusa, and 50 to 100 parts of skeleton material. Compared with the prior art, the compound preparation for treating the gastric ulcer provided by the invention has no toxic or side effect, has a comprehensive treatment effect and can effectively treat the gastric ulcer; one-time medicament application of a plurality of medicaments is realized; the effect is remarkable; the compound preparation for treating the gastric ulcer has a certain development value.

Description

technical field [0001] The invention relates to a compound preparation for treating gastric ulcer, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Gastric ulcer is a common digestive tract disease. Because gastric ulcer is the most common, so-called peptic ulcer generally refers to gastric ulcer. Ulcer is formed by gastric acid and pepsin digesting the mucosa itself. In fact, gastric acid and pepsin are only One of the main reasons for the formation of ulcers, there are other reasons for the formation of peptic ulcers; with the growth of modern social and economic development, people's awareness of competition has increased, in order to save time, resulting in modern eating disorders, overwork, mental stress, Smoking, alcoholism and other factors increase the incidence of gastric ulcer year by year. This disease is very harmful to the body, often causing hunger discomfort, fullness, pantothenic acid, abdominal pain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K47/48A61K47/36A61K47/38A61K47/34A61P1/04A61K36/8966A61K36/748A61K36/537A61K31/4439A61K33/06
CPCA61K36/9066A61K31/4439A61K33/06A61K36/537A61K36/748A61K36/8966A61K47/34A61K47/36A61K47/38A61K2300/00
Inventor 不公告发明人
Owner QINGDAO BAIRUIJI BIOTECH
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