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Obstructive sleep apnea hypopnea syndrome mouse model modeling device

A technology for sleep apnea and hypoventilation, which is applied in medical science, veterinary equipment, equipment for restraining animals, etc., to achieve the effect of long duration, non-flammable and explosive, and low cost

Active Publication Date: 2017-06-27
萃英科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] OSAHS animal model currently has no recognized evaluation criteria, mainly depends on whether the animal model is consistent with human OSAHS disease characteristics

Method used

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  • Obstructive sleep apnea hypopnea syndrome mouse model modeling device
  • Obstructive sleep apnea hypopnea syndrome mouse model modeling device
  • Obstructive sleep apnea hypopnea syndrome mouse model modeling device

Examples

Experimental program
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Embodiment 1

[0065] Such as figure 1 and figure 2 As shown, the obstructive sleep apnea hypopnea syndrome mouse model modeling device of this embodiment includes a mouse body container 3, a head tube 9, a connecting ring 7, an opening and closing mechanism, an air bag 4, and a controller 15;

[0066] The rat body container 3 is used to accommodate the rat body;

[0067] The head tube 9 is used to accommodate the head of the mouse, and the mouse body container 3 communicates with the head tube 9 through a connecting ring 7; the end of the mouse body container 3 near the head tube 9 has a bayonet 6, through which The connecting ring 7 is further tightened by passing the screw through the bayonet 6 , so as to realize the firm connection between the rat body container 3 and the head cylinder 9 .

[0068] The air bag 4 is positioned at the position where the mouse body container 3 communicates with the head tube 9, the air bag 4 has a through hole for the head of the mouse to pass through, a...

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Abstract

The invention discloses a modeling device for a mouse with an OSAHS (obstructive sleep apnea hypopnea syndrome). The modeling device comprises a mouse body container, a head cylinder, an opening and closing mechanism and an air bag, wherein the mouse body container is used for accommodating a mouse body; the head cylinder is used for accommodating the mouse head, and the mouse body container is communicated with the head cylinder; the air bag is located in a position where the mouse body container and the head cylinder are communicated, a through hole allowing penetration of the mouse head is formed in the air bag, and the air bag can locate the mouse neck and block air ventilation between the mouse body container and the head cylinder during inflation; an air hole is formed in one end of the head cylinder, and the opening and closing mechanism is matched with the air hole and used for controlling opening and closing of the air hole. The device can comprehensively stimulate a pathophysiological process of the OSAHS, thereby providing a good animal model for basic research of the OSAHS.

Description

technical field [0001] The invention relates to an experimental animal mouse model modeling device for obstructive sleep apnea hypopnea syndrome (OSAHS), especially suitable for using rats or mice to study obstructive sleep apnea hypopnea syndrome basic research. Background technique [0002] Obstructive sleep apnea hypopnea syndrome (OSAHS) has a high incidence and great harm, and is closely related to multiple systemic diseases such as hypertension, coronary heart disease, diabetes, and stroke. Some studies suggest that repeated hypoxia, micro-awakening and sleep deprivation are important factors causing body damage in patients with OSAHS during sleep, but the specific pathogenesis is still not very clear. For this reason, people are constantly researching and exploring various animal models in order to simulate the pathophysiological processes of patients with sleep apnea, such as upper airway collapse and intermittent hypoxia, so as to further study the pathogenesis of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D3/00A61D7/04
CPCA61D7/04
Inventor 魏永祥吴昊
Owner 萃英科技(北京)有限公司
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