32 results about "Sleep Apnea Hypopnea Syndrome" patented technology

The invention relates to an elastic tongue dorsum traction apparatus and a method for implanting the same. The elastic tongue dorsum traction apparatus and the method are used for treating patients suffering from sleep apnea-hypopnea syndromes or snoring. The elastic tongue dorsum traction apparatus comprises a tongue dorsum connecting mechanism, elastic traction bodies and tooth-side fixators. A support body of the tongue dorsum connecting mechanism is implanted under the mucosa of the tongue dorsum of a patient, and the elastic traction bodies and the tongue dorsum connecting mechanism are exposed out of the mucosa of the tongue dorsum of the patient. The tooth-side fixators are fixed to the inner sides of the teeth or the alveolar bones of the patient, one end of each elastic traction body is connected with the corresponding tooth-side fixator, and the other end of each elastic traction body is connected with the tongue dorsum connecting mechanism. The elastic tongue dorsum traction apparatus and the method have the advantages that the tooth-side fixators are used as support points, the elastic traction bodies can exert elastic tractive force on the tongue dorsum connecting mechanism, accordingly, the glossocoma tongue of the patient can be pulled up forwardly, airway stenosis and obstruction of the glossopharyngeal part of the patient can be prevented, and snoring and OSAHS (obstructive sleep apnea-hypopnea syndrome) treatment effects can be realized; an elastic traction effect is realized for the tongue dorsum connecting mechanism by the elastic traction bodies, so that movement of the tongue of the patient is unaffected while the tongue of the patient is moderately pulled up, certain swallowing and speaking functions can be kept, the airway of the glossopharyngeal part of the patient can be expanded, and the patient feels comfortable when using the elastic tongue dorsum traction apparatus.

The invention relates to an obstructive sleep apnea-hypopnea syndrome (OSAHS) screening method and a device. Formant characteristics of snore are adopted as technical indexes for screening OSAHS; Snore sections are extracted by a short-time energy method at first, then LPC (linear predictive coding) is used for modeling, after predicting factors of the LPC are obtained, a first formant frequency of each snore section is obtained by a root extraction method, as ranges of formant frequencies of different modes are different, the different snore sections can be distinguished, all first formant frequencies of all snorers are classified, by the aid of K mean values, and thresholds for distinguishing normal snore and abnormal snore of individuals are determined according to classified results; and then AHI (apnea-hypopnea indexes) in a PSG (polysomnogram) are simulated so that average times of apnea and hypopnea of the snorers within an hour are obtained. According to the OSAHS judgment standard, whether the data section has snore of a normal person or snore of a patient with the OSAHS is judged. The obstruction sleep apnea-hypopnea syndrome screening method and the device are low in cost, high in applicability and simple in operation and are non-contacting.

The invention discloses an obstructive sleep apnea-hypopnea syndrome (OSAHS) patient preliminary screening system. The preliminary screening system comprises a singlechip microcomputer, a computer, a mouth-nose airflow monitoring module, a thoracoabdominal respiratory movement monitoring module and a blood oxygen and heart rate monitoring module, wherein the mouth-nose airflow monitoring module, the thoracoabdominal respiratory movement monitoring module and the blood oxygen and heart rate monitoring module are connected with the singlechip microcomputer in a wired or wireless manner; and the singlechip microcomputer is connected with the computer in the wired or wireless manner. A sleep monitoring system comprises three core sleep monitoring modules of mouth-nose airflow monitoring, thoracoabdominal respiratory movement monitoring and blood oxygen and heart rate monitoring and is utilized to preliminarily screen out OSAHS patients from sleep breathing disorder diseases, on the one hand, more scientific monitoring data is obtained, and on the other hand, the number of sensors on patients can be reduced to the maximum extent; and moreover, the system monitors the patients in natural sleep states at home, and the obtained data is relatively in accordance with the practical sleep states of the patients in daily lives. Particularly, after a video / audio module is arranged, the preliminary screening system can more vividly show the apnea and labored breathing symptoms of the sleeping patients, and warns the patients to get treatment in a specialized sleep hospital in time.

The invention discloses a household preliminary detecting system of SAHS (Sleep Apnea Hypopnea Syndrome). The household preliminary detecting system comprises a collecting device and an intelligent detecting device, wherein the collecting device is used for collecting snoring audio data of a patient; the intelligent detecting device is used for receiving the snoring audio data and carrying out preliminary detection; the collecting device is connected with the intelligent detecting device; and the intelligent detecting device comprises a collecting module which is used for collecting snoring data, a detecting module which is used for calculating an AHI (Apnea Hypopnea Index) value, and a judging module which is used for presetting a threshold value, and the patient can be determined to suffer from suspected SAHS if a current AHI value is larger than the threshold value.

The invention relates to a preliminary screening method for sleep apnea hypopnea syndrome with low physiological load. Using ECG and respiratory signals extracted from pulse waves and using data processing and classification algorithm, ECG signal were analyzed in frequency domain to obtain heart rate variability index for cardiac function evaluation, and then combine HRV with respiratory signals,sleep staging and event discrimination of obstructive sleep apnea syndrome were performed with machine learning trained classifier, the invention reduces the types of signals needed to be detected byfurther mining the information related to sleep contained in the signals, and can carry out sleep analysis and cardiac function evaluation only by collecting blood oxygen pulse signals, thereby achieving the purpose of reducing physiological and psychological load of a subject and more convenient and accurate measurement.

The invention discloses a sleep apnea hypopnea syndrome detection system and method. The system includes a data acquisition device (100) and an analysis processing device (200); the data acquisition device (100) comprises an electrocardiosignal acquisition unit (110) and a blood oxygen signal acquisition unit (120) which are used for acquiring electrocardiosignals and blood oxygen signals of the human body respectively; the analysis processing device (200) comprises a calculation unit (210) which is used for extracting respiration signals from the electrocardiosignals, identifying the apnea and hypopnea states in real time according to the respiration signals and the blood oxygen signals, calculating the apnea hypopnea index and analyzing the sleep state of the human body to obtain an analysis result. The system has the advantages of being easy to operate, convenient to wear, good in comfort and high in real-time performance.

The present invention relates to a soft palate superelastic NiTi support for curing obstructive sleep aponea low-ventilation syndrome and its preparation method. It is characterized by that the described support is formed into a closed tongue-shaped structure made up by using superelastic NiTi marmem wire material through a certain winding process. Besides, said invention also provides the concrete steps of its preparation method.

The invention aims at providing a medical instrument which is applicable to light and intermediate obstructive sleep apnea-hypopnea syndromes and capable of relieving or eliminating the snore symptom. According to the medical instrument, the inadequacies of non-surgical treatment or surgical treatment of the obstructive sleep apnea-hypopnea syndrome are solved.

The invention discloses traditional Chinese medicine composition for treating obstructive sleep apnea and hypoventilation syndrome. According to traditional Chinese medicine, the phlegm and blood stasis resistance is the important reason for aggravation of the OSAHS disease and various complications, so that in treatment, the principle of reducing and eliminating phlegm as well as tonifying and activating blood is adopted. According to the traditional Chinese medicine composition for treating obstructive sleep apnea and hypoventilation syndrome, traditional Chinese medicine Tai pai small tatarian aster, ligularia sibirica, atalantia buxifolia roots, rocky mountain flowers, corydalis tuber, sodium ferlate, trichosanthes kirilowii maxim, whorlleaf stonecrop herb roots, ventilago leiocarpa benth and korean raspberry roots are decocted with water to be decocted, the total effective rate is 92% which is obviously superior to 78% of the contrast group, and the traditional Chinese medicine composition has remarkable effects on the aspects of improving clinical symptoms of OSAHS patients and reliving the state of illness.

The invention relates to the field of molecular biology and medicines, and discloses a variation site of an obstructive sleep apnea hypopnea syndrome susceptibility gene ADIPOQ and a detection method and application of the variation site in detecting susceptibility of obstructive sleep apnea hypopnea syndromes. The invention further discloses a method for predicting the risk of the obstructive sleep apnea hypopnea syndromes by detecting the genotype of the variation site. The method comprises the following steps: extracting genomic DNA (Deoxyribonucleic Acid) of a sample, performing specific amplification, performing detection, analyzing the genotype of the variation site, and the like. Tests show that if the site has genotype variation, the risk of the obstructive sleep apnea hypopnea syndromes is increased. The invention further discloses a kit for detecting the susceptibility of the obstructive sleep apnea hypopnea syndromes.

The invention provides a healthcare pillow which comprises a headrest part, wherein a middle part of a front edge of the headrest part is upward bulged and formed into a neck rest part; the upward bulged height of the neck rest part is 2cm-4cm; the two ends of the headrest part are bulged toward one side of the front edge relative to the main body of the headrest part and are formed into two opposite face rest parts; the two opposite face rest parts are connected with the main body of the headrest part and are formed into a U-shaped sunken part; the width of the sunken part is more than or equal to 33cm. The healthcare pillow provided by the invention can support the cervical vertebra and cheeks of people while sleeping on one side, can reduce the pressure on the shoulder blade on one side, can prevent cervical vertebra distortion and can prevent cervical spondylosis and scapulohumeral periarthritis; the healthcare pillow is beneficial to sleeping on one side but is unbeneficial to sleeping on back; the healthcare pillow can prevent uvula and tongue root from falling backward and choking pharyngeal cavity, can maintain airway unblocked and can relieve obstructive sleep apnea hypopnea syndrome; a sensor is arranged on the neck rest part and is used for monitoring and collecting the sleeping physiological data; the pillow-side equipment is adopted for sending the data to the third party through Bluetooth, so that the cardiocerebral events can be early warned.

Disclosed is a sleep breathing pathological typing method, comprising: obtaining the frequency of respiratory disorder events in a snoring interval during the sleep of a monitored person, wherein the snoring interval is a period from the end of a snore to the start of the next snore (S101, S201); and performing typing according to the frequency of respiratory disorder events in the snoring interval, wherein the respiratory disorder events comprise hypopnea and apnoea (S102, S202, S203, S204). The method performs the typing of snoring according to the frequency of respiratory disorder events in the snoring interval, closely connects snoring with breathing disorder events, makes the analysis of snoring more detailed and specific, enriches the research in the field of snoring, and lies the foundation for the diagnosis of sleep apnea hypopnea syndrom via snoring analysis.

The invention discloses a sleep apnea hypopnea hypoventilation syndrome animal model device and method. The sleep apnea hypopnea hypoventilation syndrome animal model device comprises a cabin body, amain control module, a sleep deprivation model device and an intermittent combined hypoxia and hypercapnia model device; the intermittent combined hypoxia and hypercapnia model device comprises at least two gas sources, one gas source is carbon dioxide gas, and the other gas source is air or oxygen; the main control module is used for controlling the oxygen concentration and the carbon dioxide concentration in the cabin body by controlling the gas supply states of the two gas sources according to the acquired oxygen concentration data and the acquired carbon dioxide gas concentration data, sothat intermittent combined hypoxia and hypercapnia is simulated; and meanwhile, the main control module also controls the sleep deprivation model device to cooperate to complete simultaneous simulation of intermittent combined hypoxia and hypercapniain a sleep deprivation state. The superposition of the three model factors can be closer to the pathophysiological mechanism for simulating the humanobstructive sleep apnea hypopnea hypoventilation syndrome.

The invention discloses a salvia miltiorrhiza extract, an injection and application thereof, which relates to the technical field of medicinal chemistry. The preparation method of the salvia miltiorrhiza extract comprises the following steps: activating a strain, that is inoculating beauveria bassiana on an SDA culture medium for culturing; amplifying the strain, that is inoculating the activatedstrain into a liquid culture medium, and culturing to obtain a strain culture solution; fermenting the medicinal materials, that is crushing the salvia miltiorrhiza into powder, adding water, sterilizing, adding a strain culture solution containing cryptochlorogenic acid, and fermenting to obtain fermented medicinal materials; separating and purifying, soaking the fermented medicinal materials with a methanol aqueous solution, carrying out ultrasonic treatment, filtering, and carrying out reduced-pressure rotary evaporation to obtain the salvia miltiorrhiza extract. According to the invention,the prepared salvia miltiorrhiza extract has high yield and excellent pharmacological activity, and the anti-inflammatory effect is enhanced. The salvia miltiorrhiza extract can be used as an injection, which has a remarkable effect on treating obstructive sleep apnea hypopnea syndrome complicated with hypertension.

The invention provides a traditional Chinese medicine composition which contains the following components in parts by weight: 3-30 parts of spleen and lung qi nourishing traditional Chinese medicines,3-20 parts of rhizoma atractylodis, 3-40 parts of poria cocos, kidney yang tonifying traditional Chinese medicines, 3-30 parts of angelica sinensis, 6-60 parts of blood activating traditional Chinesemedicine, 3-60 parts of liquorice, and 90-130 parts of heat clearing and toxicity removing traditional Chinese medicine. Compared with the prior art, according to the invention, the spleen and lung qi nourishing traditional Chinese medicine, rhizoma atractylodis, poria cocos and kidney yang tonifying traditional Chinese medicine are taken as monarch drugs, which are targeted to the root of viscera deficiency, and can tonify spleen and reinforce kidney to eradicate the source of producing phlegm, tonify qi to help activating blood to expel toxic substances, and tonify qi and nourish yin to help sleeping; angelica sinensis, the blood activating traditional Chinese medicine and the heat clearing and toxicity removing traditional Chinese medicine are taken as ministerial drugs, which can clear away heat and remove toxicity, promote blood circulation and remove blood stasis, and ventilate viscera qi stasis; liquorice is taken as a conductant drug, which can expel phlegm to arrest coughingand resolve hundreds of toxins; the whole formula achieves the effects of removing stasis and detoxifying, and consolidating and dredging collaterals, so that extravasated blood is removed, and deficient root is consolidated, and therefore, the traditional Chinese medicine composition achieves a better treatment effect in treating chronic obstructive pulmonary disease and / or sleep apnea hypopnea syndrome.

The invention discloses an electrical stimulation device used for an obstructive sleep apnea hypopnea syndrome, and relates to the technical field of medical apparatus and instruments. The electrical stimulation device used for the obstructive sleep apnea hypopnea syndrome comprises a first reinforced connecting shell, wherein one side of the first reinforced connecting shell is provided with a regulation mechanism, the bottom of the first reinforced connecting shell is provided with a connecting wire, and one end of the connecting wire is provided with a spacing mechanism. The electrical stimulation device used for the obstructive sleep apnea hypopnea syndrome is provided with the regulation mechanism and the spacing mechanism, while a pulse inductor can be fixed, the electrical stimulation device can be suitable for patients with different arm sizes, when a spacing rib is pulled out, a distance between the first reinforced connecting shell and a second reinforced connecting shell is increased for being suitable for the patients of different body types, and meanwhile, through electric discharge stimulation of an electrical stimulation component, a state of an illness is alleviated while the patient who is seriously ill is protected from oxygen deficiency.

The present invention relates to an improved adjustable polysomnography device. The improved adjustable polysomnography device is characterized by comprising a head sleeve body; the head sleeve body presents a semicircular structure and is provided with two arc-shaped openings in a surface; and oval openings are arranged in both sides of the head sleeve body and hook and loop fasteners are arranged on a bottom part. Advantages are as follows: the head sleeve body is designed according to fixed positions of all kinds of electrodes in a head and face part, during sleep monitoring, the electrodesare placed in the corresponding positions of the head and face part of patients to the head sleeve body, tightness degree of the head sleeve body is adjusted, the electrodes are not easy to fall offafter wearing, and besides, the improved adjustable polysomnography device can avoid conflict sense of patients for existing white brain surgery head sleeves, thus relaxes patients' mood, enables patients to be peaceful in night sleep, ensures sleep quality, provides scientific foundation for clarifying diagnosis, and is suitable for the patients with sleep apnea hypopnea syndrome.

The invention discloses a household preliminary detecting system of SAHS (Sleep Apnea Hypopnea Syndrome). The household preliminary detecting system comprises a collecting device and an intelligent detecting device, wherein the collecting device is used for collecting snoring audio data of a patient; the intelligent detecting device is used for receiving the snoring audio data and carrying out preliminary detection; the collecting device is connected with the intelligent detecting device; and the intelligent detecting device comprises a collecting module which is used for collecting snoring data, a detecting module which is used for calculating an AHI (Apnea Hypopnea Index) value, and a judging module which is used for presetting a threshold value, and the patient can be determined to suffer from suspected SAHS if a current AHI value is larger than the threshold value.

The invention provides a sleep apnea hypopnea syndrome (SAHS) evaluation method and device based on a target detection framework, wherein mouth-nose airflow and chest pressure data in sleep monitoring data are selected as data basis of SAHS evaluation, a target detection model fusing the mouth-nose airflow and the chest pressure data is designed, and the model comprises three main parts: respectively processing mouth-nose airflow and chest pressure data in a time sequence form, and fusing extracted features; carrying out adaptive regression on the basis of a region proposal network (RPN) to generate a candidate frame for SAHS fragment detection; and generating scale-invariant features based on the candidate segments and classifying the scale-invariant features. According to the invention, model training adopts an alternate training mode, and a RPN network and a classification network are trained respectively; and a focal loss function is used to alleviate a deviation problem possibly caused by model training under an unbalanced sample.

The invention relates to an elastic tongue dorsum traction apparatus and a method for implanting the same. The elastic tongue dorsum traction apparatus and the method are used for treating patients suffering from sleep apnea-hypopnea syndromes or snoring. The elastic tongue dorsum traction apparatus comprises a tongue dorsum connecting mechanism, elastic traction bodies and tooth-side fixators. A support body of the tongue dorsum connecting mechanism is implanted under the mucosa of the tongue dorsum of a patient, and the elastic traction bodies and the tongue dorsum connecting mechanism are exposed out of the mucosa of the tongue dorsum of the patient. The tooth-side fixators are fixed to the inner sides of the teeth or the alveolar bones of the patient, one end of each elastic traction body is connected with the corresponding tooth-side fixator, and the other end of each elastic traction body is connected with the tongue dorsum connecting mechanism. The elastic tongue dorsum traction apparatus and the method have the advantages that the tooth-side fixators are used as support points, the elastic traction bodies can exert elastic tractive force on the tongue dorsum connecting mechanism, accordingly, the glossocoma tongue of the patient can be pulled up forwardly, airway stenosis and obstruction of the glossopharyngeal part of the patient can be prevented, and snoring and OSAHS (obstructive sleep apnea-hypopnea syndrome) treatment effects can be realized; an elastic traction effect is realized for the tongue dorsum connecting mechanism by the elastic traction bodies, so that movement of the tongue of the patient is unaffected while the tongue of the patient is moderately pulled up, certain swallowing and speaking functions can be kept, the airway of the glossopharyngeal part of the patient can be expanded, and the patient feels comfortable when using the elastic tongue dorsum traction apparatus.

The invention provides a method for evaluating a respiratory airflow stimulating factor during reopening of an air passage. The method can be applied to electrostimulation and respirator triggering methods for treating SAHS (Sleep Apnea Hypopnea Syndrome) patients and can also be applied to some sleep intervention methods for treating SAHS, for example adjustment on trigger points of sleep postures with pillows. The method comprises the following steps: S1. separately acquiring a breast band signal Tho and an abdominal band signal Abd of a respiration event during the reopening of the air passage, so as to calculate a pulmonary volume change; S2. calculating a pulmonary negative pressure change by using the pulmonary volume change; evaluating negative-pressure factor stimulation by using the pulmonary negative pressure change; S3. acquiring a blood oxygen signal of the respiration event during the reopening of the air passage, and calculating a blood oxygen lowering maximum value and a maximum lowering speed, so as to evaluate chemical factor stimulation; S4. evaluating the size of the respiratory airflow stimulating factor required during the reopening of the air passage by using the negative-pressure factor stimulation and the chemical factor stimulation as joint stimulating factors.

The invention provides use of securinine in preparing medicines for treating OSAHS (obstructive sleep apnea hypopnea syndrome). Peripherally administered securinine reaches hypoglossal nerve motor nuclei through a blood-brain barrier, directly activates the hypoglossal nerve motor neclei by inhibiting GABAA current in the postsynaptic membrane, and further activates the genioglossus muscle through the hypoglossal nerve to enable the genioglossus muscle to contract, so that the collapsed upper airway is reopened to achieve the purpose of treatment of OSAHS. Compared with continuous positive airway pressure ventilation, the securinine has the advantages of high acceptability of patients, no need of being applied continuously throughout the sleep period, cheap price and cost-effective effect. Compared with other drugs, the securinine has the advantages of definite effects, high safety, small side effects, and peripheral administration.

The invention discloses a salvia miltiorrhiza extract, an injection and an application thereof, and relates to the technical field of medicinal chemistry. The preparation method of the salvia miltiorrhiza extract specifically comprises: activating the strains, inoculating Beauveria bassiana on SDA medium for cultivation; amplifying the strains, inoculating the above-mentioned activated strains in a liquid medium and culturing them to obtain the strains culture medium; the medicinal material is fermented, the salvia miltiorrhiza is crushed into powder, water is added, sterilized, and the bacterial culture liquid containing cryptochlorogenic acid is added for fermentation to obtain the fermented medicinal material; the fermented medicinal material is obtained by separating and purifying, soaking the above-mentioned fermented medicinal material with methanol aqueous solution, ultrasonication, filtration, reduction The extract of Danshen was obtained by rotary steaming. The prepared salvia miltiorrhiza extract has high yield, excellent pharmacological activity and enhanced anti-inflammation effect; it can be made into injections for treating obstructive sleep apnea hypoventilation syndrome combined with hypertension, and the effect is remarkable.

The invention provides a method for evaluating a respiratory airflow stimulating factor during reopening of an air passage. The method can be applied to electrostimulation and respirator triggering methods for treating SAHS (Sleep Apnea Hypopnea Syndrome) patients and can also be applied to some sleep intervention methods for treating SAHS, for example adjustment on trigger points of sleep postures with pillows. The method comprises the following steps: S1. separately acquiring a breast band signal Tho and an abdominal band signal Abd of a respiration event during the reopening of the air passage, so as to calculate a pulmonary volume change; S2. calculating a pulmonary negative pressure change by using the pulmonary volume change; evaluating negative-pressure factor stimulation by using the pulmonary negative pressure change; S3. acquiring a blood oxygen signal of the respiration event during the reopening of the air passage, and calculating a blood oxygen lowering maximum value and a maximum lowering speed, so as to evaluate chemical factor stimulation; S4. evaluating the size of the respiratory airflow stimulating factor required during the reopening of the air passage by using the negative-pressure factor stimulation and the chemical factor stimulation as joint stimulating factors.

The invention provides a traditional Chinese medicine composition, which, in parts by weight, comprises: 3-30 parts of traditional Chinese medicines for invigorating spleen and lung qi; 3-20 parts of Atractylodes Rhizoma; 3-40 parts of Poria; ; Angelica 3-30 copies; blood-activating traditional Chinese medicines 6-60 copies; licorice 3-60 copies; heat-clearing and detoxifying traditional Chinese medicines 9-130 copies. Compared with the prior art, the present invention uses traditional Chinese medicines of the spleen and lung type, Atractylodes Rhizoma, Poria, and the traditional Chinese medicines of nourishing kidney-yang as the monarch medicine, which can aim at the root of the deficiency of the viscera, strengthen the spleen and the kidney, and eliminate the source of phlegm. Qi can help promote blood circulation and go out with toxins, nourishing qi and nourishing yin to help sleep; Angelica, blood-activating traditional Chinese medicines, and heat-clearing and detoxifying traditional Chinese medicines are ministerial medicines, clearing heat and detoxifying, promoting blood circulation and removing blood stasis, dispersing viscera and supporting qi; Dispelling phlegm and relieving cough, and detoxification; the whole recipe has the effect of removing blood stasis and detoxification, strengthening the root and dredging collaterals, so that the congestion can be removed, the root deficiency can be solidified, and it is used in the treatment of chronic obstructive pulmonary disease and / or sleep apnea hypopnea syndrome. achieved better results.

The invention discloses a modeling device for a mouse with an OSAHS (obstructive sleep apnea hypopnea syndrome). The modeling device comprises a mouse body container, a head cylinder, an opening and closing mechanism and an air bag, wherein the mouse body container is used for accommodating a mouse body; the head cylinder is used for accommodating the mouse head, and the mouse body container is communicated with the head cylinder; the air bag is located in a position where the mouse body container and the head cylinder are communicated, a through hole allowing penetration of the mouse head is formed in the air bag, and the air bag can locate the mouse neck and block air ventilation between the mouse body container and the head cylinder during inflation; an air hole is formed in one end of the head cylinder, and the opening and closing mechanism is matched with the air hole and used for controlling opening and closing of the air hole. The device can comprehensively stimulate a pathophysiological process of the OSAHS, thereby providing a good animal model for basic research of the OSAHS.