Variation site of obstructive sleep apnea hypopnea syndrome susceptibility gene ADIPOQ and detection method and application of variation site

Abstract

The invention relates to the field of molecular biology and medicines, and discloses a variation site of an obstructive sleep apnea hypopnea syndrome susceptibility gene ADIPOQ and a detection method and application of the variation site in detecting susceptibility of obstructive sleep apnea hypopnea syndromes. The invention further discloses a method for predicting the risk of the obstructive sleep apnea hypopnea syndromes by detecting the genotype of the variation site. The method comprises the following steps: extracting genomic DNA (Deoxyribonucleic Acid) of a sample, performing specific amplification, performing detection, analyzing the genotype of the variation site, and the like. Tests show that if the site has genotype variation, the risk of the obstructive sleep apnea hypopnea syndromes is increased. The invention further discloses a kit for detecting the susceptibility of the obstructive sleep apnea hypopnea syndromes.

Description

technical field [0001] The invention relates to the fields of molecular biology and medicine, in particular to a variation site of an obstructive sleep apnea hypopnea syndrome susceptibility gene ADIPOQ gene, and also relates to a detection method and a detection kit for the variation site. Background technique [0002] Obstructive sleep apnea-hypopnea-hypopnea syndrome (OSAHS) is periodic upper airway obstruction during sleep that causes apnea and hypopnea, causing repeated hypoxemia. OSAHS is currently recognized as a systemic disease. In 2008, the American Heart Association (AHA) / American College of Cardiology Foundation (ACCF) issued a scientific statement stating that OSAHS is a newly recognized and possible disease in cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease, heart failure, arrhythmia, and stroke. Independent risk factors for intervention, OSAHS has become a major public health problem. The 2015 ESC Guidelines for the M...

AI Technical Summary

Problems solved by technology

Its main manifestation in OSAHS patients is decreased expression level, which may be due to abnormal expression regulation, but there are still few studies on ADIPOQ gene variation and transcriptional regulation in OSAHS patients

In particular, there is a lack of research on ADIPOQ gene variation sites in the Chinese population. In view of the fact that the sites of single nucleotide variation in the same gene between different races often have certain differences, it is necessary to study the ADIPOQ gene variation in the Chinese population. Conduct in-depth research on the sites, strive to find relevant sites and establish corresponding detection methods, and promote the application in the screening, prevention, early diagnosis and treatment of obstructive sleep apnea hypopnea syndrome susceptible population in China

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